Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jennifer W Gin"'
Autor:
Yan Chen, Nurgul Kaplan Lease, Jennifer W Gin, Tadeusz L Ogorzalek, Paul D Adams, Nathan J Hillson, Christopher J Petzold
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0264467 (2022)
Manual proteomic sample preparation methods limit sample throughput and often lead to poor data quality when thousands of samples must be analyzed. Automated liquid handler systems are increasingly used to overcome these issues for many of the sample
Externí odkaz:
https://doaj.org/article/7b68da2188174dafa99db78bf35152d3
Autor:
Yan Chen, Jonathan Vu, Mitchell G Thompson, William A Sharpless, Leanne Jade G Chan, Jennifer W Gin, Jay D Keasling, Paul D Adams, Christopher J Petzold
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211582 (2019)
Recent improvements in the speed and sensitivity of liquid chromatography-mass spectrometry systems have driven significant progress toward system-wide characterization of the proteome of many species. These efforts create large proteomic datasets th
Externí odkaz:
https://doaj.org/article/7933fc3cdf984cf28589921c6f825458
Autor:
Michael S Kobor, Shivkumar Venkatasubrahmanyam, Marc D Meneghini, Jennifer W Gin, Jennifer L Jennings, Andrew J Link, Hiten D Madhani, Jasper Rine
Publikováno v:
PLoS Biology, Vol 2, Iss 5, p E131 (2004)
The conserved histone variant H2A.Z functions in euchromatin to antagonize the spread of heterochromatin. The mechanism by which histone H2A is replaced by H2A.Z in the nucleosome is unknown. We identified a complex containing 13 different polypeptid
Externí odkaz:
https://doaj.org/article/7161aceb167d49fa992ba18d946d7992
Autor:
Rosana Goldbeck, Manoela Martins, Alberto M. M. Lopes, Thomas Eng, Yan Chen, Jennifer W. Gin, Christopher Petzold, Aindrila Mukopadhyay, Flávia V. Winck
New approaches to increase productivity and reduce costs may improve the use of lignocellulosic biomass in biorefineries, benefiting the biobased economy and reducing political and environmental instabilities from fossil sources. The deletion of MNN1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27fabbc320f5f299d1aff37ef69c599f
https://doi.org/10.2139/ssrn.4399170
https://doi.org/10.2139/ssrn.4399170
Autor:
Elias Englund, Matthias Schmidt, Alberto A. Nava, Anna Lechner, Kai Deng, Renee Jocic, Yingxin Lin, Jacob Roberts, Veronica T. Benites, Ramu Kakumanu, Jennifer W. Gin, Yan Chen, Yuzhong Liu, Christopher J. Petzold, Edward E. K. Baidoo, Trent R. Northen, Paul D. Adams, Leonard Katz, Satoshi Yuzawa, Jay D. Keasling
Publikováno v:
Journal of the American Chemical Society : JACS 145(16), 8822-8832 (2023). doi:10.1021/jacs.2c11027
Englund, E, Schmidt, M, Nava, A A, Lechner, A, Deng, K, Jocic, R, Lin, Y, Roberts, J, Benites, V T, Kakumanu, R, Gin, J W, Chen, Y, Liu, Y, Petzold, C J, Baidoo, E E K, Northen, T R, Adams, P D, Katz, L, Yuzawa, S & Keasling, J D 2023, ' Expanding Extender Substrate Selection for Unnatural Polyketide Biosynthesis by Acyltransferase Domain Exchange within a Modular Polyketide Synthase ', Journal of the American Chemical Society, vol. 145, no. 16, pp. 8822-8832 . https://doi.org/10.1021/jacs.2c11027
Journal of the American Chemical Society, vol 145, iss 16
Englund, E, Schmidt, M, Nava, A A, Lechner, A, Deng, K, Jocic, R, Lin, Y, Roberts, J, Benites, V T, Kakumanu, R, Gin, J W, Chen, Y, Liu, Y, Petzold, C J, Baidoo, E E K, Northen, T R, Adams, P D, Katz, L, Yuzawa, S & Keasling, J D 2023, ' Expanding Extender Substrate Selection for Unnatural Polyketide Biosynthesis by Acyltransferase Domain Exchange within a Modular Polyketide Synthase ', Journal of the American Chemical Society, vol. 145, no. 16, pp. 8822-8832 . https://doi.org/10.1021/jacs.2c11027
Journal of the American Chemical Society, vol 145, iss 16
Journal of the American Chemical Society : JACS 145(16), 8822-8832 (2023). doi:10.1021/jacs.2c11027
Published by American Chemical Society Publications, Washington, DC
Published by American Chemical Society Publications, Washington, DC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c971887b3df730f910a42b92d61ae6d7
Autor:
Liyuan Jin, Yan Chen, Fei Gan, Jay D. Keasling, Christopher J. Petzold, Bo Pang, Jennifer W. Gin, Chunsheng Yan
Publikováno v:
Journal of the American Chemical Society. 142:10931-10935
Nonribosomal peptide synthetase (NRPS) oxidase (Ox) domains oxidize protein-bound intermediates to install crucial structural motifs in bioactive natural products. The mechanism of this domain remains elusive. Here, by studying indigoidine synthetase
Autor:
Julie B. Nielsen, Yaojun Tong, Emil Thomsen, Tadas Jakočiūnas, Christopher J. Petzold, Pep Charusanti, Charlotte Held Gotfredsen, Kai Blin, Jennifer W. Gin, Michael Krogh Jensen, Eftychia E. Kontou, Andreas Klitgaard, Rasmus John Normand Frandsen, Sang Yup Lee, Tilmann Weber, David Romero-Suarez, Jay D. Keasling
Publikováno v:
Synthetic and Systems Biotechnology, Vol 5, Iss 1, Pp 11-18 (2020)
Jakočiūnas, T, Klitgaard, A K, Kontou, E E, Nielsen, J B, Thomsen, E, Romero Suarez, D, Blin, K, Petzold, C J, Gin, J W, Tong, Y, Gotfredsen, C H, Charusanti, P, Frandsen, R J N, Weber, T, Lee, S Y, Jensen, M K & Keasling, J D 2020, ' Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast ', Synthetic and Systems Biotechnology, vol. 5, no. 1, pp. 11-18 . https://doi.org/10.1016/j.synbio.2020.01.004
Synthetic and Systems Biotechnology
Synthetic and systems biotechnology, vol 5, iss 1
Jakočiūnas, T, Klitgaard, A K, Kontou, E E, Nielsen, J B, Thomsen, E, Romero Suarez, D, Blin, K, Petzold, C J, Gin, J W, Tong, Y, Gotfredsen, C H, Charusanti, P, Frandsen, R J N, Weber, T, Lee, S Y, Jensen, M K & Keasling, J D 2020, ' Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast ', Synthetic and Systems Biotechnology, vol. 5, no. 1, pp. 11-18 . https://doi.org/10.1016/j.synbio.2020.01.004
Synthetic and Systems Biotechnology
Synthetic and systems biotechnology, vol 5, iss 1
To accelerate the shift to bio-based production and overcome complicated functional implementation of natural and artificial biosynthetic pathways to industry relevant organisms, development of new, versatile, bio-based production platforms is requir
Autor:
Pablo Cruz-Morales, Kevin Yin, Alexander Landera, John R. Cort, Robert P. Young, Jennifer E. Kyle, Robert Bertrand, Anthony T. Iavarone, Suneil Acharya, Aidan Cowan, Yan Chen, Jennifer W. Gin, Corinne D. Scown, Christopher J. Petzold, Carolina Araujo-Barcelos, Eric Sundstrom, Anthe George, Yuzhong Liu, Sarah Klass, Alberto A. Nava, Jay D. Keasling
Publikováno v:
Cruz-Morales, P, Yin, K, Landera, A, Cort, J R, Young, R P, Kyle, J E, Bertrand, R, Iavarone, A T, Acharya, S, Cowan, A, Chen, Y, Gin, J W, Scown, C D, Petzold, C J, Araujo-Barcelos, C, Sundstrom, E, George, A, Liu, Y, Klass, S, Nava, A A & Keasling, J D 2022, ' Biosynthesis of polycyclopropanated high energy biofuels ', Joule, vol. 6, no. 7, pp. 1590-1605 . https://doi.org/10.1016/j.joule.2022.05.011
Cyclopropane-functionalized hydrocarbons are excellent fuels due their high energy density. However, the organic synthesis of these molecules is challenging. In this work, we produced polycyclopropanated fatty acids in bacteria. These molecules can b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2809976307ac8e145dfc226251510d8
https://orbit.dtu.dk/en/publications/c8eea5c0-a67c-4c79-8196-96fdc9c2d75d
https://orbit.dtu.dk/en/publications/c8eea5c0-a67c-4c79-8196-96fdc9c2d75d
Autor:
Blake A. Simmons, Benjamin P. Bowen, Kai Deng, Anup K. Singh, Trent R. Northen, Martina Aulitto, Paul D. Adams, Steve W. Singer, Thanh Le Mai Pham, Kenneth L. Sale, Yan Chen, Christopher J. Petzold, Nicole L Ing, Jennifer W. Gin
Publikováno v:
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports
Lignocellulosic biomass is composed of three major biopolymers: cellulose, hemicellulose and lignin. Analytical tools capable of quickly detecting both glycan and lignin deconstruction are needed to support the development and characterization of eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9505a61fd6d7bc7ce758162dbb3b3ca2
https://hdl.handle.net/11588/918199
https://hdl.handle.net/11588/918199
Autor:
Christopher J. Petzold, Paul D. Adams, Leonard Katz, Edward E. K. Baidoo, Jose Henrique Pereira, Jay D. Keasling, Yan Chen, Jennifer W. Gin, Danika Nimlos, Jeffrey Chen, Catalina Alonso-Martinez, Rohith N. Krishna, Pablo Cruz-Morales, Leanne Jade G. Chan, Jesus F. Barajas, Jacquelyn M. Blake-Hedges, Mitchell G. Thompson
Publikováno v:
Journal of the American Chemical Society, vol 142, iss 2
Blake-Hedges, J M, Pereira, J H, Cruz-Morales, P, Thompson, M G, Barajas, J F, Chen, J, Krishna, R N, Chan, L J G, Nimlos, D, Alonso-Martinez, C, Baidoo, E E K, Chen, Y, Gin, J W, Katz, L, Petzold, C J, Adams, P D & Keasling, J D 2020, ' Structural Mechanism of Regioselectivity in an Unusual Bacterial Acyl-CoA Dehydrogenase ', Journal of the American Chemical Society, vol. 142, no. 2, pp. 835-846 . https://doi.org/10.1021/jacs.9b09187
Blake-Hedges, J M, Pereira, J H, Cruz-Morales, P, Thompson, M G, Barajas, J F, Chen, J, Krishna, R N, Chan, L J G, Nimlos, D, Alonso-Martinez, C, Baidoo, E E K, Chen, Y, Gin, J W, Katz, L, Petzold, C J, Adams, P D & Keasling, J D 2020, ' Structural Mechanism of Regioselectivity in an Unusual Bacterial Acyl-CoA Dehydrogenase ', Journal of the American Chemical Society, vol. 142, no. 2, pp. 835-846 . https://doi.org/10.1021/jacs.9b09187
Terminal alkenes are easily derivatized, making them desirable functional group targets for polyketide synthase (PKS) engineering. However, they are rarely encountered in natural PKS systems. One mechanism for terminal alkene formation in PKSs is thr