Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jennifer Venhorst"'
Autor:
Manuel A. González Hernández, Lars Verschuren, Martien P.M. Caspers, Martine C. Morrison, Jennifer Venhorst, Jelle T. van den Berg, Beatrice Coornaert, Roeland Hanemaaijer, Gerard J. P. van Westen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The incidence of MASLD and MASH-associated fibrosis is rapidly increasing worldwide. Drug therapy is hampered by large patient variability and partial representation of human MASH fibrosis in preclinical models. Here, we investigated the mec
Externí odkaz:
https://doaj.org/article/655a3f5a3c6143cd8f62fdeaec52efc2
Autor:
Jennifer Venhorst, Roeland Hanemaaijer, Remon Dulos, Martien P. M. Caspers, Karin Toet, Joline Attema, Christa de Ruiter, Gino Kalkman, Tanja Rouhani Rankouhi, Jelle C. B. C. de Jong, Lars Verschuren
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
An in silico target discovery pipeline was developed by including a directional and weighted molecular disease network for metabolic dysfunction-associated steatohepatitis (MASH)-induced liver fibrosis. This approach integrates text mining, network b
Externí odkaz:
https://doaj.org/article/2ed7e1d7d253401ab02b8a54abdd0c8d
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The pathogenic Clostridioides difficile and Clostridium perfringens are responsible for many health care-associated infections as well as systemic and enteric diseases. Therefore, they represent a major health threat to both humans and animals. Conce
Externí odkaz:
https://doaj.org/article/eaed50199a4b45fcae5cd85123b3dc09
Publikováno v:
Current Drug Targets. 23:1345-1369
Background:Cardiovascular disease (CVD) is a leading cause of death worldwide. It is predicted that approximately 23.6 million people will die from CVDs annually by 2030. Therefore, there is a great need for an effective therapeutic approach to comba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310025048f157842b498812a928eb86d
https://doi.org/10.2174/1389450123666220811101032
https://doi.org/10.2174/1389450123666220811101032
Autor:
Lars Verschuren, Jennifer Venhorst, Tanja Rouhani Rankouhi, Annemette V. Thougaard, Jorrit J. Hornberg
Publikováno v:
Handbook of Biomarkers and Precision Medicine ISBN: 9780429202872
Handbook of Biomarkers and Precision Medicine
Handbook of Biomarkers and Precision Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb554feff2307c28dc6e89c013503c3a
https://doi.org/10.1201/9780429202872-8
https://doi.org/10.1201/9780429202872-8
Autor:
A.G. Foley, Kruse Cornelis G, M.A.W. van der Neut, M. van Drimmelen, E. Andriambeloson, N.M.W.J. de Bruin, Josephus H. M. Lange, Jos Prickaerts, M. van der Wetering, K.M. Wicke, M. de Haan, A. van Loevezijn, L. de Groote, Jennifer Venhorst
Publikováno v:
Neurobiology of Learning and Memory, 133, 100-117. Elsevier Science
In the present study, our aim was to investigate whether the novel highly selective 5-hydroxytryptamine(6) (5-HT6) receptor antagonist SLV can ameliorate impairments in cognition and social interaction with potential relevance for both schizophrenia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ae85c00885124a2cd3d6150529a2b2
https://doi.org/10.1016/j.nlm.2016.06.020
https://doi.org/10.1016/j.nlm.2016.06.020
Autor:
Josephus H. M. Lange, Remco Henzen, Natasja de Bruin, Jelle de Vries, Wouter I. Iwema Bakker, Wouter de Looff, Arnold P. den Hartog, Stefan Verhoog, Rob P. van de Woestijne, Chris G. Kruse, Arnold van Loevezijn, Jennifer Venhorst, Martina A.W. van der Neut
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1605-1611
The discovery of non-basic N'-(arylsulfonyl)pyrazoline-1-carboxamidines as 5-HT6 antagonists with unique structural features was recently disclosed. Here we describe how this structural class was further developed by addressing an unexplored interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf6abbf2099e90ec1e67445cecda377
https://doi.org/10.1016/j.bmcl.2016.02.001
https://doi.org/10.1016/j.bmcl.2016.02.001
Autor:
Cor G de Korte, Stefan Verhoog, Martina A.W. van der Neut, Wouter I. Iwema Bakker, Alice J.M. Borst, Jennifer Venhorst, Chris G. Kruse, Natasja de Bruin, Rob P. van de Woestijne, Hiskias G. Keizer, Arnold van Loevezijn, Wouter de Looff, Jan-Willem van Wees, Maria J.P. van Dongen, Martijn van Hoeve
Publikováno v:
Journal of Medicinal Chemistry. 54:7030-7054
The 5-HT(6) receptor (5-HT(6)R) has been in the spotlight for several years regarding CNS-related diseases. We set out to discover novel, neutral 5-HT(6)R antagonists to improve off-target selectivity compared to basic amine-containing scaffolds domi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01b80e49fd141f75bc4e9afb4ff68b46
https://doi.org/10.1021/jm200466r
https://doi.org/10.1021/jm200466r
Autor:
Kruse Cornelis G, A. van Loevezijn, Sven Akkerman, Jennifer Venhorst, P. Houba, Olga A.H. Reneerkens, L. de Groote, Jos Prickaerts, N.M.W.J. de Bruin
Publikováno v:
Neurobiology of Learning and Memory, 96(2), 392-402. Elsevier Science
The 5-hydroxytryptamine(6) (5-HT(6)) receptor has been suggested to play an important role in the regulation of memory and cognition. In the present study, our aim was to investigate whether the novel, selective 5-HT(6) antagonists compound (CMP) X a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c45f4a4c72c0b50078a5fea5e6da85
https://doi.org/10.1016/j.nlm.2011.06.015
https://doi.org/10.1016/j.nlm.2011.06.015
Autor:
Fred J. van de Brug, Eugene P. van Someren, Gino J. Kalkman, Jennifer Venhorst, Simon Folkertsma
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 93:143
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06eab1305f8a580c89c80f15a57e5bba
https://doi.org/10.1016/j.vascn.2018.01.475
https://doi.org/10.1016/j.vascn.2018.01.475