Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jennifer V. Gerbracht"'
Autor:
Volker Boehm, Sabrina Kueckelmann, Jennifer V. Gerbracht, Sebastian Kallabis, Thiago Britto-Borges, Janine Altmüller, Marcus Krüger, Christoph Dieterich, Niels H. Gehring
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Degradation of nonsense mediated mRNA decay (NMD) substrates is carried out by two seemingly independent pathways, SMG6-mediated endonucleolytic cleavage and/or SMG5-SMG7-induced accelerated deadenylation. Here the authors show that SMG5-SMG7 maintai
Externí odkaz:
https://doaj.org/article/9c2915beac40413f8c56308a467df541
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Degradation of messenger RNA is a key regulatory step in controlling eukaryotic gene expression. Here the authors present xrFrag, a molecular tool to interrogate the extent and directionality of mRNA turnover by the detection of stabilized decay inte
Externí odkaz:
https://doaj.org/article/4df3f5547cd041fa9a60258e7949e822
CASC3 promotes transcriptome-wide activation of nonsense-mediated decay by the exon junction complex
Autor:
Niels H. Gehring, Janica L Wiederstein, Dominik Aschemeier, Jennifer V. Gerbracht, Simona Ciriello, Janine Altmüller, Christian K. Frese, Thiago Britto-Borges, Christoph Dieterich, Volker Boehm, Marcus Krueger, Sebastian Kallabis
Publikováno v:
Nucleic Acids Research
The exon junction complex (EJC) is an essential constituent and regulator of spliced messenger ribonucleoprotein particles (mRNPs) in metazoans. As a core component of the EJC, CASC3 was described to be pivotal for EJC-dependent nuclear and cytoplasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93c9065d3ff03c8fc471d610d3a3eff
https://doi.org/10.1093/nar/gkaa564
https://doi.org/10.1093/nar/gkaa564
Autor:
Jennifer V. Gerbracht, Tommy Harding, Alastair G. B. Simpson, Andrew J. Roger, Sebastian Hess
Publikováno v:
Current biology : CB. 32(15)
SummaryMicrobial eukaryotes display a stunning diversity of feeding strategies, ranging from generalist predators to highly specialised parasites. The unicellular “protoplast feeders” represent a fascinating mechanistic intermediate, as they pene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709b4f38ddc5069ae8187c079b5fddc4
https://pubmed.ncbi.nlm.nih.gov/35700733
https://pubmed.ncbi.nlm.nih.gov/35700733
Autor:
Ivana Horvathova, Volker Boehm, Jan Eglinger, Jeffrey A. Chao, Franka Voigt, Jennifer V. Gerbracht, Niels H. Gehring
Publikováno v:
Nature Protocols. 14:1603-1633
RNA degradation ensures appropriate levels of mRNA transcripts within cells and eliminates aberrant RNAs. Detailed studies of RNA degradation dynamics have been heretofore infeasible because of the inherent instability of degradation intermediates du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c911496a984d605fdb75befcb7dd2f7
https://doi.org/10.1038/s41596-019-0152-8
https://doi.org/10.1038/s41596-019-0152-8
Autor:
Sebastian Kallabis, Thiago Britto-Borges, Niels H. Gehring, Christoph Dieterich, Jennifer V. Gerbracht, Sabrina Kueckelmann, Marcus Krüger, Volker Boehm, Janine Altmüller
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Eukaryotic gene expression is constantly controlled by the translation-coupled nonsense-mediated mRNA decay (NMD) pathway. Aberrant translation termination leads to NMD activation, resulting in phosphorylation of the central NMD factor UPF1 and robus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::335eb809dbf1c462a750bdef9c2f47a7
https://pubmed.ncbi.nlm.nih.gov/34172724
https://pubmed.ncbi.nlm.nih.gov/34172724
Autor:
Christoph Dieterich, Volker Boehm, Niels H. Gehring, Janine Altmueller, Sabrina Kueckelmann, Thiago Britto-Borges, Jennifer V. Gerbracht
Eukaryotic gene expression is constantly regulated and controlled by the translation-coupled nonsense-mediated mRNA decay (NMD) pathway. Aberrant translation termination leads to NMD activation and robust clearance of NMD targets via two seemingly in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14dc216151fdd86cb7372470c09cc482
https://doi.org/10.1101/2020.07.07.191437
https://doi.org/10.1101/2020.07.07.191437
Publikováno v:
Biochemical Society Transactions. 46:153-161
During splicing, the exon junction complex (EJC) is deposited upstream of exon-exon boundaries. The EJC and its peripheral bound proteins play an essential role in mediating mRNA export, translation and turnover. However, the exact sequence of EJC as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0453714f5984556657f13ee8f74206
https://doi.org/10.1042/bst20170059
https://doi.org/10.1042/bst20170059
Autor:
Niels H. Gehring, Isabel Saez, Moritz Horn, Hyun Ju Lee, David Vilchez, Seda Koyuncu, Virginia Kroef, Christoph Dieterich, Martin S. Denzel, Jennifer V. Gerbracht
Publikováno v:
FEBS Lett
UBR5 is an E3 ubiquitin ligase involved in distinct processes such as transcriptional regulation and development. UBR5 is highly upregulated in embryonic stem cells (ESCs), whereas its expression decreases with differentiation, suggesting a role for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2540bf4886c4f1f8cad63da8627bad0
https://hdl.handle.net/21.11116/0000-000B-30B2-5
https://hdl.handle.net/21.11116/0000-000B-30B2-5
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Messenger RNA (mRNA) turnover is a crucial and highly regulated step of gene expression in mammalian cells. This includes mRNA surveillance pathways such as nonsense-mediated mRNA decay (NMD), which assesses the fidelity of transcripts and eliminates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8000d38396911bd128552202adf7d32
https://doi.org/10.1038/s41598-017-10847-4
https://doi.org/10.1038/s41598-017-10847-4