Výsledky vyhledávání - "Jennifer Umhoefer"

A Localized Materials‐Based Strategy to Non‐Virally Deliver Chondroitinase ABC mRNA Improves Hindlimb Function in a Rat Spinal Cord Injury Model

Autor: Andrew S. Khalil, Daniel Hellenbrand, Kaitlyn Reichl, Jennifer Umhoefer, Mallory Filipp, Joshua Choe, Amgad Hanna, William L. Murphy

Publikováno v: Advanced Healthcare Materials. 11:2200206

Spinal cord injury often results in devastating consequences for those afflicted, with very few therapeutic options. A central element of spinal cord injuries is astrogliosis, which forms a glial scar that inhibits neuronal regeneration post-injury.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1360917ab2a9c1f727e9f59faddda6f3
https://doi.org/10.1002/adhm.202200206

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CRISPRi and KO screens reveal integrated cis- and trans-regulation of the CD28, CTLA4, and ICOS locus in primary human T cells

Autor: Cody Mowery, Jacob Freimer, Jennifer Umhoefer, Christian Garrido, Ralf Schmidt, Zachary Steinhart, Benjamin Gowen, Gemma Curie, Jacob Corn, Jimmie Chun Ye, Alexander Marson

Publikováno v: The Journal of Immunology. 208:56.17-56.17

Costimulation is essential for complete T cell activation, requiring the coordinated expression of various surface proteins including those encoded by CD28 family members CD28, CTLA4, and ICOS. Interestingly, these three genes lie adjacently in a top

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::552923479845ae2233c605d9b86c9986
https://doi.org/10.4049/jimmunol.208.supp.56.17

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