Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jennifer Totman"'
Autor:
Joshua S. Alford, John W. Lampe, Dorothy Brach, Richard Chesworth, Kat Cosmopoulos, Kenneth W. Duncan, Sean T. Eckley, Jeffrey L. Kutok, Alejandra Raimondi, Thomas V. Riera, Brian Shook, Cuyue Tang, Jennifer Totman, Neil A. Farrow
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1137-1143
SETD2, a lysine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0923d93af3913acf097ff9afc7c6e1
https://doi.org/10.1021/acsmedchemlett.2c00167
https://doi.org/10.1021/acsmedchemlett.2c00167
Autor:
Michael J Thomenius, Jennifer Totman, Darren Harvey, Lorna H Mitchell, Thomas V Riera, Kat Cosmopoulos, Alexandra R Grassian, Christine Klaus, Megan Foley, Elizabeth A Admirand, Haris Jahic, Christina Majer, Tim Wigle, Suzanne L Jacques, Jodi Gureasko, Dorothy Brach, Trupti Lingaraj, Kip West, Sherri Smith, Nathalie Rioux, Nigel J Waters, Cuyue Tang, Alejandra Raimondi, Michael Munchhof, James E Mills, Scott Ribich, Margaret Porter Scott, Kevin W Kuntz, William P Janzen, Mikel Moyer, Jesse J Smith, Richard Chesworth, Robert A Copeland, P Ann Boriack-Sjodin
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197372 (2018)
A key challenge in the development of precision medicine is defining the phenotypic consequences of pharmacological modulation of specific target macromolecules. To address this issue, a variety of genetic, molecular and chemical tools can be used. A
Externí odkaz:
https://doaj.org/article/8d24a066e3c44272bf8a8c8842bb3428
Autor:
Thomas V. Riera, Lampe John W, Cuyue Tang, Kat Cosmopoulos, Alejandra Raimondi, Michael John Munchhof, Neil A. Farrow, Kenneth W. Duncan, Dorothy Brach, Vinny Motwani, Darren Martin Harvey, P. Ann Boriak-Sjodin, Sean T. Eckley, Jennifer Totman, Joshua S Alford, Megan Alene Cloonan Foley, Michael J Thomenius
Publikováno v:
ACS Medicinal Chemistry Letters
SET domain-containing protein 2 (SETD2), a histone methyltransferase, has been identified as a target of interest in certain hematological malignancies, including multiple myeloma. This account details the discovery of EPZ-719, a novel and potent SET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c70d3b49c7dd565ec207bc48d880872
https://pubmed.ncbi.nlm.nih.gov/34671445
https://pubmed.ncbi.nlm.nih.gov/34671445
Autor:
Jennifer Totman, Kevin Wayne Kuntz, Megan Alene Cloonan Foley, Lorna Helen Mitchell, Nathalie Rioux, Thomas V. Riera, James Edward John Mills, Suzanne L. Jacques, Robert A. Copeland, Tim J. Wigle, Alejandra Raimondi, Kip A. West, P. Ann Boriack-Sjodin, Sherri Smith, Margaret Porter Scott, Michael John Munchhof, Christine Klaus, Michael Thomenius, Nigel J. Waters, J. Joshua Smith, Richard Chesworth
Publikováno v:
ACS Medicinal Chemistry Letters. 7:134-138
SMYD3 has been implicated in a range of cancers; however, until now no potent selective small molecule inhibitors have been available for target validation studies. A novel oxindole series of SMYD3 inhibitors was identified through screening of the E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2276a83671eb4bf0b31912fb398a2e24
https://doi.org/10.1021/acsmedchemlett.5b00272
https://doi.org/10.1021/acsmedchemlett.5b00272
Autor:
Cuyue Tang, Michael John Munchhof, Kat Cosmopoulos, Kip A. West, Mikel P. Moyer, Sherri Smith, Lorna Helen Mitchell, Margaret Porter Scott, Haris Jahic, Alexandra R. Grassian, Megan Alene Cloonan Foley, Thomas V. Riera, Darren Martin Harvey, Scott Ribich, P. Ann Boriack-Sjodin, Kevin Wayne Kuntz, Nigel J. Waters, Dorothy Brach, Christine Klaus, J. Joshua Smith, Robert A. Copeland, Trupti Lingaraj, Elizabeth A. Admirand, Jennifer Totman, Michael Thomenius, Christina R. Majer, Tim J. Wigle, Richard Chesworth, Alejandra Raimondi, Jodi Gureasko, Nathalie Rioux, James Edward John Mills, Suzanne L. Jacques, William P. Janzen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 6, p e0197372 (2018)
PLoS ONE, Vol 13, Iss 6, p e0197372 (2018)
A key challenge in the development of precision medicine is defining the phenotypic consequences of pharmacological modulation of specific target macromolecules. To address this issue, a variety of genetic, molecular and chemical tools can be used. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db6179ff168da8f29fc3b07b8965b83d
https://pubmed.ncbi.nlm.nih.gov/29856759
https://pubmed.ncbi.nlm.nih.gov/29856759
Autor:
Kat Cosmopoulos, Kenneth W. Duncan, Lampe John W, J. Joshua Smith, Thomas V. Riera, Neil A. Farrow, Richard Chesworth, Lei Ci, Dorothy Brach, Michael J Thomenius, Jennifer Totman, Cuyue Tang
Publikováno v:
Blood. 132:3207-3207
t(4;14) chromosome translocations are found in 15% of newly diagnosed multiple myeloma (MM) cases and are associated with high risk. MM cells with t(4;14) over-express the histone methyltransferase (HMT), WHSC1/MMSET/NSD2, which leads to deregulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6b4a81f7fbd2ffa0247c25750a988d1
https://doi.org/10.1182/blood-2018-99-110803
https://doi.org/10.1182/blood-2018-99-110803
Autor:
Lorna Helen Mitchell, James Edward John Mills, J. Joshua Smith, Nathalie Rioux, Christine Klaus, Thomas V. Riera, Nigel J. Waters, Paula Ann Boriack-Sjodin, Suzanne L. Jacques, Sherri Smith, Michael Thomenius, Kevin Wayne Kuntz, Michael John Munchhof, Megan Alene Cloonan Foley, Richard Chesworth, Jennifer Totman, Robert A. Copeland, Tim J. Wigle, Alejandra Raimondi, Margaret Porter Scott
Publikováno v:
Molecular Cancer Therapeutics. 14:C85-C85
SMYD3 (Set and Mynd Domain containing 3) is a lysine methyltransferase overexpressed in several cancer types including breast, prostrate, pancreatic, and lung, and this overexpression is associated with poor clinical prognosis. Genetic knockdown of S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba2ceb125f31c5783539d9ea0acf81e1
https://doi.org/10.1158/1535-7163.targ-15-c85
https://doi.org/10.1158/1535-7163.targ-15-c85
Autor:
Thomenius, Michael J.1 mthomenius@epizyme.com, Totman, Jennifer1, Harvey, Darren1, Mitchell, Lorna H.1, Riera, Thomas V.1, Cosmopoulos, Kat1, Grassian, Alexandra R.1, Klaus, Christine1, Foley, Megan1, Admirand, Elizabeth A.1, Jahic, Haris1, Majer, Christina1, Wigle, Tim1, Jacques, Suzanne L.1, Gureasko, Jodi1, Brach, Dorothy1, Lingaraj, Trupti1, West, Kip1, Smith, Sherri1, Rioux, Nathalie1
Publikováno v:
PLoS ONE. 1/6/2018, Vol. 13 Issue 5, p1-21. 21p.
Autor:
Pan, Darren, Richter, Joshua
Publikováno v:
Frontiers in Oncology; 1/20/2022, Vol. 11, p1-11, 11p
Publikováno v:
Gene Therapy. Apr2014, Vol. 21 Issue 4, p363-370. 8p.