Analysis of spironolactone polymorphs in active pharmaceutical ingredients and their effect on tablet dissolution profiles

Autor: Renata Cunha de Resende, Olímpia Maria Martins Santos Viana, Jennifer Tavares Jacon Freitas, Rudy Bonfilio, André Luís Morais Ruela, Magali Benjamim de Araújo

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Vol 52, Iss 4, Pp 613-621

ABSTRACT Spironolactone (SPR) is a steroidal drug administered as a potassium-sparing diuretic for high blood pressure treatment. The drug shows incomplete gastrointestinal absorption due to its poor aqueous solubility. The physicochemical properties

Externí odkaz: https://doaj.org/article/bcaa941258374b0bbca8c0c06664c08f

Aplicação da difração de raios X por monocristais na caracterização de insumos farmacêuticos ativos

Autor: Jennifer Tavares Jacon Freitas, Luan F. Diniz, Renata Diniz

Publikováno v: Journal of Experimental Techniques and Instrumentation. 4:92-129

A difração de raios X por monocristais é uma técnica muito importante na caracterização de novos compostos cristalinos, pois permite a descrição dos comprimentos e ângulos de ligações químicas bem como das interações intermoleculares re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11ecc1cafb63d0aee221cca04585f7a4
https://doi.org/10.30609/jeti.v4i03.13040

Preclinical Evaluation of Polymeric Nanocomposite Containing Pregabalin for Sustained Release as Potential Therapy for Neuropathic Pain

Autor: Thamyris Reis Moraes, Gislaine Ribeiro Pereira, Rafaela Figueiredo Rodrigues, Paloma Freitas dos Santos, Rodrigo Vicentino Placido, Flávia Chiva Carvalho, Sandra Barbosa Neder Agostini, Vanessa Bergamin Boralli, Giovane Galdino, Jennifer Tavares Jacon Freitas, Juliana Cancino-Bernardi, Juliana Barbosa Nunes

Publikováno v: Polymers
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Polymers, Vol 13, Iss 3837, p 3837 (2021)
Volume 13
Issue 21

This study offers a novel oral pregabalin (PG)-loaded drug delivery system based on chitosan and hypromellose phthalate-based polymeric nanocomposite in order to treat neuropathic pain (PG-PN). PG-PN has a particle size of 432 ± 20 nm, a polydispers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e87f2ce914fbc14d6150c7224439afe6
http://europepmc.org/articles/PMC8587775

Development and characterization of nanostructured lipid carrier-based gels for the transdermal delivery of donepezil

Autor: Jennifer Tavares Jacon Freitas, André Luís Morais Ruela, I.T. Mendes, Rudy Bonfilio, Flávia Chiva Carvalho, Gislaine Ribeiro Pereira

Publikováno v: Colloids and Surfaces B: Biointerfaces. 177:274-281

Donepezil is one of the main compounds used in the therapy of Alzheimer's disease. Oral administration of this drug presents many drawbacks, resulting in treatment non-adherence among patients. Thus, the development of transdermal formulations for do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4c4c8434a5a2c8341a5d8eefbb7e68
https://doi.org/10.1016/j.colsurfb.2019.02.007

Crystal Structure of Levofloxacin Anhydrates: A High-Temperature Powder X-ray Diffraction Study Versus Crystal Structure Prediction

Autor: Jennifer Tavares Jacon Freitas, Cristiane C. de Melo, Fabio Furlan Ferreira, Olimpia Maria Martins Santos Viana, Antonio C. Doriguetto

Publikováno v: Crystal Growth & Design. 18:3558-3568

Levofloxacin, the levo-isomer of the antibiotic ofloxacin, can crystallize into two different hydrate forms, the monohydrate and the hemihydrate. Although these forms are well characterized, little is known about their anhydrous structures besides th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14667aeee9dc62d65d0dbcb27f6fadcc
https://doi.org/10.1021/acs.cgd.8b00363