Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jennifer Stratton"'
Autor:
Karen Lariosa-Willingham, Dmitri Leonoudakis, Florian Simon, Kendall Walker, Philippe Guillaume, Liling Warren, Jennifer Stratton
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-7 (2023)
Abstract Objectives Animal models of skin disease are used to evaluate therapeutics to alleviate disease. One common clinical dermatological complaint is pruritus (itch), but there is a lack of standardization in the characterization of pre-clinical
Externí odkaz:
https://doaj.org/article/5c04a0c322b541439ed55470227f9595
Autor:
Nicola Benedicter, Karl Messlinger, Birgit Vogler, Kimberly D. Mackenzie, Jennifer Stratton, Nadine Friedrich, Mária Dux
Publikováno v:
Neurology International, Vol 15, Iss 2, Pp 622-637 (2023)
Migraine pain is frequently accompanied by cranial hyperalgesia and allodynia. Calcitonin gene-related peptide (CGRP) is implicated in migraine pathophysiology but its role in facial hypersensitivity is not entirely clear. In this study, we investiga
Externí odkaz:
https://doaj.org/article/110e2c9230c44f9785e7fc996db02cb2
Autor:
Nicola Benedicter, Birgit Vogler, Annette Kuhn, Jana Schramm, Kimberly D. Mackenzie, Jennifer Stratton, Mária Dux, Karl Messlinger
Publikováno v:
Cells, Vol 13, Iss 7, p 572 (2024)
Calcitonin gene-related peptide (CGRP) and nitric oxide (NO) have been recognized as important mediators in migraine but their mechanisms of action and interaction have not been fully elucidated. Monoclonal anti-CGRP antibodies like fremanezumab are
Externí odkaz:
https://doaj.org/article/35d813fc18a14de7914939d7292fc780
Autor:
Karen Lariosa-Willingham, Dmitri Leonoudakis, Timo Bragge, Laura Tolppanen, Antti Nurmi, Megan Flanagan, Janelle Gibson, David Wilson, Jennifer Stratton, Kimmo K. Lehtimäki, Diana Miszczuk
Publikováno v:
BMC Neuroscience, Vol 23, Iss 1, Pp 1-12 (2022)
Abstract Background Therapeutic agents stimulating the process of myelination could be beneficial for the treatment of demyelinating diseases, such as multiple sclerosis. The efficient translation of compounds promoting myelination in vitro to effica
Externí odkaz:
https://doaj.org/article/6a43bef6c05a44c498bd5a3f3b1919a9
Autor:
Kimberly D. Mackenzie, Mario Ortega, Yoel Kessler, Verena Ramirez Campos, Lynda J. Krasenbaum, Karen Carr, Xiaoping Ning, Jennifer Stratton
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Calcitonin gene-related peptide (CGRP) pathway-targeted treatments have been shown to be efficacious in the prevention of episodic and chronic migraine. Currently approved therapies include monoclonal antibodies (mAbs) that target CGRP (eptinezumab,
Externí odkaz:
https://doaj.org/article/f0c7a8dc921146898c7fe90a37c8d9e7
Autor:
Joshua M. Cohen, Xiaoping Ning, Yoel Kessler, Michele Rasamoelisolo, Verena Ramirez Campos, Michael J. Seminerio, Lynda J. Krasenbaum, Honglue Shen, Jennifer Stratton
Publikováno v:
The Journal of Headache and Pain, Vol 22, Iss 1, Pp 1-8 (2021)
Abstract Background Monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway have been shown to be effective in migraine prevention. Eptinezumab, erenumab, fremanezumab, and galcanezumb have shown efficacy in clinical
Externí odkaz:
https://doaj.org/article/30df5c3385fd4b69b2d270618060643e
The Anti-CGRP Antibody Fremanezumab Lowers CGRP Release from Rat Dura Mater and Meningeal Blood Flow
Autor:
Mária Dux, Birgit Vogler, Annette Kuhn, Kimberly D. Mackenzie, Jennifer Stratton, Karl Messlinger
Publikováno v:
Cells, Vol 11, Iss 11, p 1768 (2022)
Monoclonal antibodies directed against the neuropeptide calcitonin gene-related peptide (CGRP) belong to a new generation of therapeutics that are effective in the prevention of migraine. CGRP, a potent vasodilator, is strongly implicated in the path
Externí odkaz:
https://doaj.org/article/e1dfe848cec743819eb2c7e06a066679
Publikováno v:
The Journal of Headache and Pain, Vol 19, Iss 1, Pp 1-6 (2018)
Abstract Background Fremanezumab (TEV-48125) is a fully humanized anti-calcitonin gene-related peptide (CGRP) monoclonal antibody (mAb) that has shown positive results in the prevention of episodic migraine and chronic migraine. Previous preclinical
Externí odkaz:
https://doaj.org/article/530372b6887e427e91aa02c8d87074a1
Autor:
John C Lin, David Tsao, Paul Barras, Raul A Bastarrachea, Bob Boyd, Joyce Chou, Rodnie Rosete, Hua Long, Alison Forgie, Yasmina Abdiche, Jeanette Dilley, Jennifer Stratton, Carlos Garcia, David L Sloane, Anthony G Comuzzie, Arnon Rosenthal
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e1900 (2008)
Loss of function mutations in the receptor tyrosine kinase TrkB pathway resulted in hyperphagia and morbid obesity in human and rodents. Conversely, peripheral or central stimulation of TrkB by its natural ligands BDNF or NT4 reduced body weight and
Externí odkaz:
https://doaj.org/article/6efe3da8a10f430793c6095c8907968a
Autor:
Beverley Greenwood-Van Meerveld, Sara Shnider, Casey O. Ligon, Jennifer Stratton, Ehsan Noor-Mohammadi, Kimberly Mackenzie
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 379:270-279
Irritable bowel syndrome (IBS) is a brain-gut disorder characterized by abdominal pain and altered bowel habits. Although the etiology of IBS remains unclear, stress in adulthood or in early life has been shown to be a significant factor in the devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8ecfadb294b19deae7da39e1ef3181
https://doi.org/10.1124/jpet.121.000731
https://doi.org/10.1124/jpet.121.000731