Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Jennifer Southgate"'
Autor:
Andrew S. Mason, Claire L. Varley, Olivia M. Foody, Xiang Li, Katie Skinner, Dawn Walker, Tony R. Larson, Daisuke Wakamatsu, Simon C. Baker, Jennifer Southgate
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11871 (2022)
Urothelium is a transitional, stratified epithelium that lines the lower urinary tract, providing a tight barrier to urine whilst retaining the capacity to stretch and rapidly resolve damage. The role of glycerophospholipids in urothelial barrier fun
Externí odkaz:
https://doaj.org/article/8ddc21c1d5fb4ed89db9c7a4fdb5bff2
Autor:
Debora Morgante, Anna Radford, Syed K Abbas, Eileen Ingham, Ramnath Subramaniam, Jennifer Southgate
Publikováno v:
Journal of Tissue Engineering, Vol 12 (2021)
Acellular matrices produced by tissue decellularisation are reported to have tissue integrative properties. We examined the potential for incorporating acellular matrix grafts during procedures where there is an inadequate natural tissue bed to suppo
Externí odkaz:
https://doaj.org/article/1e34701250d542588308f4f860c4549b
Autor:
Vanessa Daza-Cajigal, Adriana S. Albuquerque, Joanna Pearson, Jennifer Hinley, Andrew S. Mason, Jens Stahlschmidt, Adrian J. Thrasher, Vibhash Mishra, Jennifer Southgate, Siobhan O. Burns
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Inherited Primary Immunodeficiency (PID) disorders are associated with increased risk of malignancy that may relate to impaired antitumor immune responses or a direct role for PID germline mutations in tumorigenesis. We recently identified germline l
Externí odkaz:
https://doaj.org/article/f4a913741e234cc5acc5d4b3790636dc
Autor:
Anne Biton, Isabelle Bernard-Pierrot, Yinjun Lou, Clémentine Krucker, Elodie Chapeaublanc, Carlota Rubio-Pérez, Nuria López-Bigas, Aurélie Kamoun, Yann Neuzillet, Pierre Gestraud, Luca Grieco, Sandra Rebouissou, Aurélien de Reyniès, Simone Benhamou, Thierry Lebret, Jennifer Southgate, Emmanuel Barillot, Yves Allory, Andrei Zinovyev, François Radvanyi
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1235-1245 (2014)
Extracting relevant information from large-scale data offers unprecedented opportunities in cancerology. We applied independent component analysis (ICA) to bladder cancer transcriptome data sets and interpreted the components using gene enrichment an
Externí odkaz:
https://doaj.org/article/fc9494082fea48fdaec4ebd243c8bd7f
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 6, p 1344 (2019)
Occupational and environmental exposure to cadmium is associated with the development of urothelial cancer. The metallothionein (MT) family of genes encodes proteins that sequester metal ions and modulate physiological processes, including zinc homeo
Externí odkaz:
https://doaj.org/article/0fef44b126d34641be49e96159131a89
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 9, Pp 1509-1515 (2000)
The role of long-chain polyunsaturated fatty acids (PUFA) in the etiopathology and treatment of cancer is poorly understood. We have studied the effects of n–3 and n–6 PUFA on the proliferation and survival of normal human uroepithelial (NHU) cel
Externí odkaz:
https://doaj.org/article/8a2524652a634d2eae12c02488a5543a
Autor:
Peter C Rubenwolf, Nikolaos T Georgopoulos, Lisa A Kirkwood, Simon C Baker, Jennifer Southgate
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45339 (2012)
It is generally considered that the bladder is impervious and stores urine in unmodified form on account of the barrier imposed by the highly-specialised uro-epithelial lining. However, recent evidence, including demonstration of aquaporin (AQP) expr
Externí odkaz:
https://doaj.org/article/d3dc4a2c520d438b925e3d5fa9897ca6
Autor:
Joel R Ho, Elodie Chapeaublanc, Lisa Kirkwood, Remy Nicolle, Simone Benhamou, Thierry Lebret, Yves Allory, Jennifer Southgate, François Radvanyi, Bruno Goud
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39469 (2012)
Growing evidence indicates that Rab GTPases, key regulators of intracellular transport in eukaryotic cells, play an important role in cancer. We analysed the deregulation at the transcriptional level of the genes encoding Rab proteins and Rab-interac
Externí odkaz:
https://doaj.org/article/c4ae0133938d45b9938250a9c9eedcec
Autor:
Jonathan M Fleming, Saqib Shabir, Claire L Varley, Lisa A Kirkwood, Angela White, Julie Holder, Ludwik K Trejdosiewicz, Jennifer Southgate
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51404 (2012)
Transforming growth factor (TGF) β has diverse and sometimes paradoxical effects on cell proliferation and differentiation, presumably reflecting a fundamental but incompletely-understood role in regulating tissue homeostasis. It is generally consid
Externí odkaz:
https://doaj.org/article/7b1b201bf39e4e68b847a1804fead7ff
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13621 (2010)
BACKGROUND: Despite the well-documented association between loss of E-cadherin and carcinogenesis, as well as the link between restoration of its expression and suppression of proliferation in carcinoma cells, the ability of E-cadherin to modulate gr
Externí odkaz:
https://doaj.org/article/e1c5c454d60f42208ebb56d4cb4a7396