Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jennifer Skibbe"'
Autor:
Chenying Li, Lei Dong, Rui Su, Ying Bi, Ying Qing, Xiaolan Deng, Yile Zhou, Chao Hu, Mengxia Yu, Hao Huang, Xi Jiang, Xia Li, Xiao He, Dongling Zou, Chao Shen, Li Han, Miao Sun, Jennifer Skibbe, Kyle Ferchen, Xi Qin, Hengyou Weng, Huilin Huang, Chunxiao Song, Jianjun Chen, Jie Jin
Publikováno v:
Haematologica, Vol 105, Iss 1 (2020)
Homoharringtonine, a plant alkaloid, has been reported to suppress protein synthesis and has been approved by the US Food and Drug Administration for the treatment of chronic myeloid leukemia. Here we show that in acute myeloid leukemia (AML), homoha
Externí odkaz:
https://doaj.org/article/41825eee54854527b6004ad87b2e9c27
Autor:
Andrew Appert, Sridhar Rao, Seok Hee Jang, Richard Dahl, Nathan Klopfenstein, William Morgan Hallas, Kirthi Pulakanti, Karen D. Cowden Dahl, Austin Boucher, Jennifer Skibbe
Publikováno v:
J Immunol
Macrophages are critical for regulating inflammatory responses. Environmental signals polarize macrophages to either a proinflammatory (M1) state or an anti-inflammatory (M2) state. We observed that the microRNA (miRNA) cluster mirn23a, coding for mi
Autor:
Rui, Su, Lei, Dong, Chenying, Li, Sigrid, Nachtergaele, Mark, Wunderlich, Ying, Qing, Xiaolan, Deng, Yungui, Wang, Xiaocheng, Weng, Chao, Hu, Mengxia, Yu, Jennifer, Skibbe, Qing, Dai, Dongling, Zou, Tong, Wu, Kangkang, Yu, Hengyou, Weng, Huilin, Huang, Kyle, Ferchen, Xi, Qin, Bin, Zhang, Jun, Qi, Atsuo T, Sasaki, David R, Plas, James E, Bradner, Minjie, Wei, Guido, Marcucci, Xi, Jiang, James C, Mulloy, Jie, Jin, Chuan, He, Jianjun, Chen
Publikováno v:
Cell. 172(1-2)
R-2-hydroxyglutarate (R-2HG), produced at high levels by mutant isocitrate dehydrogenase 1/2 (IDH1/2) enzymes, was reported as an oncometabolite. We show here that R-2HG also exerts a broad anti-leukemic activity in vitro and in vivo by inhibiting le
Autor:
Brian W. Ogilvie, Andrew Parkinson, Fred Tonelli, Etsuko Usuki, Anne Schmitt-Hoffmann, Dawn Baumgardner, Jennifer Skibbe, Mark D. Johnson, Gary Eichenbaum, Jeff Holsapple
Publikováno v:
Journal of Pharmaceutical Sciences. 101:1242-1252
An approach was developed that uses enzyme inhibitors to support the assessment of the pathways that are responsible for the conversion of intravenously administered ester and amide prodrugs in different biological matrices. The methodology was appli
Autor:
Dan Brobst, Brandy L. Paris, Florence Ndikum-Moffor, Etsuko Usuki, Andrew Parkinson, Jennifer Skibbe, Ivan King, Brian W. Ogilvie, Alaa-Eldin F Nassar, Lois J. Haupt, Rebecca Campbell
Publikováno v:
Drug Metabolism and Disposition. 37:1922-1930
Laromustine (VNP40101M, also known as Cloretazine) is a novel sulfonylhydrazine alkylating (anticancer) agent. Laromustine generates two types of reactive intermediates: 90CE and methylisocyanate. When incubated with rat, dog, monkey, and human liver