Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jennifer Simkin"'
Autor:
Stefan Sarkovich, Peter P. Issa, Andrew Longanecker, Davis Martin, Kaitlyn Redondo, Patrick McTernan, Jennifer Simkin, Luis Marrero
Publikováno v:
Journal of Experimental Orthopaedics, Vol 10, Iss 1, Pp n/a-n/a (2023)
Abstract Purpose Synovial fibrosis (SFb) formation and turnover attributable to knee osteoarthritis (KOA) can impart painful stiffness and persist following arthroplasty. To supplement joint conditioning aimed at maximizing peri‐operative function,
Externí odkaz:
https://doaj.org/article/b351186a845d4b16b2af91492a91ea5e
Autor:
Robert J Tower, Emily Busse, Josue Jaramillo, Michelle Lacey, Kevin Hoffseth, Anyonya R Guntur, Jennifer Simkin, Mimi C Sammarco
Publikováno v:
eLife, Vol 11 (2022)
De novo limb regeneration after amputation is restricted in mammals to the distal digit tip. Central to this regenerative process is the blastema, a heterogeneous population of lineage-restricted, dedifferentiated cells that ultimately orchestrates r
Externí odkaz:
https://doaj.org/article/2a598576685044ffb8c6917409c773c1
Autor:
Kevin Hoffseth, Emily Busse, Josue Jaramillo, Jennifer Simkin, Michelle Lacey, Mimi C. Sammarco
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mouse digit amputation provides a useful model of bone growth after injury, in that the injury promotes intramembranous bone formation in an adult animal. The digit tip is composed of skin, nerves, blood vessels, bones, and tendons, all of which rege
Externí odkaz:
https://doaj.org/article/02439c29627e4ba285ed252a6e6a940c
Autor:
Jennifer Simkin, PhD, John Valentino, BS, Wentao Cao, MS, Christina McCarthy, BS, Jonathan Schuon, MD, Jacob Davis, MD, Luis Marrero, PhD, Vinod Dasa, MD, Claudia Leonardi, PhD, Qingzhao Yu, PhD
Publikováno v:
JBJS Open Access, Vol 6, Iss 3 (2021)
Background:. Studies on symptomatic osteoarthritis suggest that Black patients report worse pain and symptoms compared with White patients with osteoarthritis. In this study, we aimed to quantify the relationship among variables such as overall healt
Externí odkaz:
https://doaj.org/article/e11ba72bcfae4e3486ada69692cd0ddd
Autor:
Thomas R. Gawriluk, Jennifer Simkin, Corin K. Hacker, John M. Kimani, Stephen G. Kiama, Vanessa O. Ezenwa, Ashley W. Seifert
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
While mammals tend to repair injuries, other adult vertebrates like salamanders and fish regenerate damaged tissue. One prominent hypothesis offered to explain an inability to regenerate complex tissue in mammals is a bias during healing toward stron
Externí odkaz:
https://doaj.org/article/fc216d4073fe46c6884b2e0d27e4bf15
Autor:
Thomas R. Gawriluk, Jennifer Simkin, Katherine L. Thompson, Shishir K. Biswas, Zak Clare-Salzler, John M. Kimani, Stephen G. Kiama, Jeramiah J. Smith, Vanessa O. Ezenwa, Ashley W. Seifert
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
The extent to which mammals and other vertebrates share similar mechanisms of tissue regeneration is unclear. Here, the authors use an ear punch assay in spiny mice, which regenerate fully, to show blastema formation and mesenchymal cell proliferatio
Externí odkaz:
https://doaj.org/article/a62c412d3ea44cd58d19b2ec254d40bb
Publikováno v:
eLife, Vol 6 (2017)
How the immune system affects tissue regeneration is not well understood. In this study, we used an emerging mammalian model of epimorphic regeneration, the African spiny mouse, to examine cell-based inflammation and tested the hypothesis that macrop
Externí odkaz:
https://doaj.org/article/bbd57cb6248d4347bc890fabd4d41f09
Autor:
Mimi C Sammarco, Jennifer Simkin, Alexander J Cammack, Danielle Fassler, Alexej Gossmann, Luis Marrero, Michelle Lacey, Keith Van Meter, Ken Muneoka
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140156 (2015)
Oxygen is critical for optimal bone regeneration. While axolotls and salamanders have retained the ability to regenerate whole limbs, mammalian regeneration is restricted to the distal tip of the digit (P3) in mice, primates, and humans. Our previous
Externí odkaz:
https://doaj.org/article/ee60b869acaa45529983dd55a8a83cac
Autor:
Yuanyuan Wu, Karen Wang, Adrine Karapetyan, Warnakulusuriya Akash Fernando, Jennifer Simkin, Manjong Han, Elizabeth L Rugg, Ken Muneoka
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54764 (2013)
A key factor that contributes to the regenerative ability of regeneration-competent animals such as the salamander is their use of innate positional cues that guide the regeneration process. The limbs of mammals has severe regenerative limitations, h
Externí odkaz:
https://doaj.org/article/79dfed8b448c44ed9b2eca47ebd1a345
Autor:
Meenakshi Umar, Garrett Bartoletti, Chunmin Dong, Apurva Gahankari, Danielle Browne, Alastair Deng, Josue Jaramillo, Mimi Sammarco, Jennifer Simkin, Fenglei He
Publikováno v:
Developmental Dynamics. 252:589-604
Mammalian calvarium is composed of flat bones developed from two origins, neural crest and mesoderm. Cells from both origins exhibit similar behavior but express distinct transcriptomes. It is intriguing to ask whether genes shared by both origins pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a5baca52ebdbd958eb2d425edaf046
https://doi.org/10.1002/dvdy.564
https://doi.org/10.1002/dvdy.564