Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jennifer Silvester"'
Autor:
Jenna E. van Leeuwen, Wail Ba-Alawi, Emily Branchard, Jennifer Cruickshank, Wiebke Schormann, Joseph Longo, Jennifer Silvester, Peter L. Gross, David W. Andrews, David W. Cescon, Benjamin Haibe-Kains, Linda Z. Penn, Deena M. A. Gendoo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Statins are promising for breast cancer therapy; dipyridamole can potentiate their effects, but is contraindicated in some cases. Here, the authors develop a pharmacogenomics pipeline to predict other compounds that potentiate statins, and validate t
Externí odkaz:
https://doaj.org/article/f57984f909454f0787ee786ab65589d9
Autor:
Zhaleh Safikhani, Petr Smirnov, Kelsie L. Thu, Jennifer Silvester, Nehme El-Hachem, Rene Quevedo, Mathieu Lupien, Tak W. Mak, David Cescon, Benjamin Haibe-Kains
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Altered mRNA splicing features in many cancers, but it has not been linked to drug response. Here, with their meta-analytic framework, the authors analyse pharmacogenomic data to identify isoform-based biomarkers predictive of in vitro drug response,
Externí odkaz:
https://doaj.org/article/cf7eac9f211140b5ac75f6d34ebece89
Autor:
Hong Xu, Marco Di Antonio, Steven McKinney, Veena Mathew, Brandon Ho, Nigel J. O’Neil, Nancy Dos Santos, Jennifer Silvester, Vivien Wei, Jessica Garcia, Farhia Kabeer, Daniel Lai, Priscilla Soriano, Judit Banáth, Derek S. Chiu, Damian Yap, Daniel D. Le, Frank B. Ye, Anni Zhang, Kelsie Thu, John Soong, Shu-chuan Lin, Angela Hsin Chin Tsai, Tomo Osako, Teresa Algara, Darren N. Saunders, Jason Wong, Jian Xian, Marcel B. Bally, James D. Brenton, Grant W. Brown, Sohrab P. Shah, David Cescon, Tak W. Mak, Carlos Caldas, Peter C. Stirling, Phil Hieter, Shankar Balasubramanian, Samuel Aparicio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Stabilization of DNA quadruplex structures (G4) is lethal for cells with a compromised DNA repair pathway. Here, the authors show that CX-5461, a small molecule in clinical trials as RNA polymerase inhibitor, has G4-stablization properties and can be
Externí odkaz:
https://doaj.org/article/5b722e62084b4032919682ab16257e1a
Author Correction: Gene isoforms as expression-based biomarkers predictive of drug response in vitro
Autor:
Zhaleh Safikhani, Petr Smirnov, Kelsie L. Thu, Jennifer Silvester, Nehme El-Hachem, Rene Quevedo, Mathieu Lupien, Tak W. Mak, David Cescon, Benjamin Haibe-Kains
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
In the original version of this Article, financial support was not fully acknowledged. This error has now been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/9191ce76cbef48729acb0b446760ba48
Autor:
Sathyen A. Prabhu, Omar Moussa, Christophe Gonçalves, Judith H. LaPierre, Hsiang Chou, Fan Huang, Vincent R. Richard, Pault Y. M. Ferruzo, Elizabeth M. Guettler, Isabel Soria-Bretones, Laura Kirby, Natascha Gagnon, Jie Su, Jennifer Silvester, Sai Sakktee Krisna, April A. N. Rose, Karen E. Sheppard, David W. Cescon, Frédérick A. Mallette, Rene P. Zahedi, Christoph H. Borchers, Sonia V. del Rincon, Wilson H. Miller
Publikováno v:
Molecular Cancer Therapeutics. 22:192-204
Aberrant cell-cycle progression is characteristic of melanoma, and CDK4/6 inhibitors, such as palbociclib, are currently being tested for efficacy in this disease. Despite the promising nature of CDK4/6 inhibitors, their use as single agents in melan
Autor:
Ethan Dmitrovsky, Xi Liu, Tak W. Mak, Ignacio I. Wistuba, Jaime Rodriguez-Canales, David W Cescon, Kelsie L. Thu, Jennifer Silvester, Luisa M. Solis, Barbara Mino, Carmen Behrens, Wei Lu, Pamela Villalobos, Jonathan M. Kurie, Lisa Maria Mustachio, Jason Roszik, Yulong Chen, Masanori Kawakami, Zibo Chen, Lin Zheng
The spindle assembly checkpoint maintains genomic integrity. A key component is tyrosine threonine kinase (TTK, also known as Mps1). TTK antagonism is hypothesized to cause genomic instability and cell death. Interrogating The Cancer Genome Atlas rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa57f94649535dc1900eeb0fa9c6cbf
https://doi.org/10.1158/1535-7163.c.6537774.v1
https://doi.org/10.1158/1535-7163.c.6537774.v1
Autor:
Wilson H. Miller, Sonia V. del Rincon, Christoph H. Borchers, Rene P. Zahedi, Frédérick A. Mallette, David W. Cescon, Karen E. Sheppard, April A. N. Rose, Sai Sakktee Krisna, Jennifer Silvester, Jie Su, Natascha Gagnon, Laura Kirby, Isabel Soria-Bretones, Elizabeth M. Guettler, Pault Y. M. Ferruzo, Vincent R. Richard, Fan Huang, Hsiang Chou, Judith H. LaPierre, Christophe Gonçalves, Omar Moussa, Sathyen A. Prabhu
Aberrant cell-cycle progression is characteristic of melanoma, and CDK4/6 inhibitors, such as palbociclib, are currently being tested for efficacy in this disease. Despite the promising nature of CDK4/6 inhibitors, their use as single agents in melan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73bca9689b5ed09aa6384274f881d0f4
https://doi.org/10.1158/1535-7163.c.6543604
https://doi.org/10.1158/1535-7163.c.6543604
Autor:
Ethan Dmitrovsky, Xi Liu, Tak W. Mak, Ignacio I. Wistuba, Jaime Rodriguez-Canales, David W Cescon, Kelsie L. Thu, Jennifer Silvester, Luisa M. Solis, Barbara Mino, Carmen Behrens, Wei Lu, Pamela Villalobos, Jonathan M. Kurie, Lisa Maria Mustachio, Jason Roszik, Yulong Chen, Masanori Kawakami, Zibo Chen, Lin Zheng
Figure S1: The structure of CFI-402257. Figure S2: TTK mRNA expression profiles in lung cancer cases with different smoking patterns, as shown in panel A. In this left panel N means no smoking history while Y indicates the presence of a smoking histo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8022f80f2f05d71c7880d9bd62d6aa72
https://doi.org/10.1158/1535-7163.22504551.v1
https://doi.org/10.1158/1535-7163.22504551.v1
Autor:
Wilson H. Miller, Sonia V. del Rincon, Christoph H. Borchers, Rene P. Zahedi, Frédérick A. Mallette, David W. Cescon, Karen E. Sheppard, April A. N. Rose, Sai Sakktee Krisna, Jennifer Silvester, Jie Su, Natascha Gagnon, Laura Kirby, Isabel Soria-Bretones, Elizabeth M. Guettler, Pault Y. M. Ferruzo, Vincent R. Richard, Fan Huang, Hsiang Chou, Judith H. LaPierre, Christophe Gonçalves, Omar Moussa, Sathyen A. Prabhu
Supplementary Figure 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be1e09a691f9bec9d9a4fb2cabfd8d6
https://doi.org/10.1158/1535-7163.22523131.v1
https://doi.org/10.1158/1535-7163.22523131.v1
Autor:
Wilson H. Miller, Sonia V. del Rincon, Christoph H. Borchers, Rene P. Zahedi, Frédérick A. Mallette, David W. Cescon, Karen E. Sheppard, April A. N. Rose, Sai Sakktee Krisna, Jennifer Silvester, Jie Su, Natascha Gagnon, Laura Kirby, Isabel Soria-Bretones, Elizabeth M. Guettler, Pault Y. M. Ferruzo, Vincent R. Richard, Fan Huang, Hsiang Chou, Judith H. LaPierre, Christophe Gonçalves, Omar Moussa, Sathyen A. Prabhu
Supplementary Figure 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3fc0dbf088b37e4e37432c377c3809
https://doi.org/10.1158/1535-7163.22523128.v1
https://doi.org/10.1158/1535-7163.22523128.v1