Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jennifer Sealy"'
Autor:
F Bourdichon, Tricia Thompson, Laura K Allred, Markus Lacorn, Jennifer Sealy-Voyksner, Jennifer North, Salvatore Parisi, Carmen Diaz-Amigo, Bert Popping, Kurt Brunner, Adrian Rogers, Jupiter Yeung, Patricia Galan-Malo
Publikováno v:
Journal of AOAC INTERNATIONAL. 101:185-189
Until recently, analytical tests for food were performed primarily in laboratories, but technical developments now enable consumers to use devices to test their food at home or when dining out. Current consumer devices for food can determine nutritio
Autor:
Roy K. Hom, Hing L. Sham, Kyle Powell, Gary Probst, Irene Griswold-Prenner, Simeon Bowers, Brian T. Peterson, Heather Zhang, Gergely Tóth, Frederique Bard, Jennifer Sealy, Karina Wong, Wayman Chan, May Lin, R. Jeffrey Neitz, Lany Ruslim, Bhushan Samant, David A. Quincy, Anh P. Truong, Robert A. Galemmo, Colin Lorentzen, Zhao Ren, Andrei W. Konradi, Mark Dryer, Wes Zmolek, Ted Yednock, Nanhua Yao, Erich Goldbach, Sarah J Wright, Hu Pan, Kevin P. Quinn, John-Michael Sauer, Dean R. Artis, George Tonn, Linda Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5521-5527
The SAR of a series of brain penetrant, trisubstituted thiophene based JNK inhibitors with improved pharmacokinetic properties is described. These compounds were designed based on information derived from metabolite identification studies which led t
Autor:
Hing L. Sham, Gergley Tóth, Karina Wong, Ann Qin, Kyle Powell, David A. Quincy, Andrei W. Konradi, Nanhua Yao, Jennifer Sealy, David Chereau, Lany Ruslim, Gary Probst, Sarah J Wright, May Lin, Ted Yednock, Irene Griswold-Prenner, Wes Zmolek, Kevin P. Quinn, Hu Pan, Roy K. Hom, Simeon Bowers, Colin Lorentzen, Frederique Bard, John P. Anderson, Anh P. Truong, Zhao Ren, Robert A. Galemmo, John-Michael Sauer, Dean R. Artis, David F. Nakamura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:315-319
In this Letter, we describe the discovery of selective JNK2 and JNK3 inhibitors, such as 10, that routinely exhibit >10-fold selectivity over JNK1 and >1000-fold selectivity over related MAPKs, p38α and ERK2. Substitution of the naphthalene ring aff
Autor:
Gergley Tóth, Hu Pan, Gary Probst, John-Michael Sauer, Dean R. Artis, Anh P. Truong, Michael P. Bova, Wes Zmolek, Ted Yednock, Jose Aquino, Michael S. Dappen, Kevin P. Quinn, Sukanto Sinha, Varghese John, Hing L. Sham, Michael A. Pleiss, Roy K. Hom, Lany Ruslim, Louis Brogley, Jennifer Sealy, Nanhua Yao, Larry Fang, Jay S. Tung, John A. Tucker, Eric Brecht, Andrei W. Konradi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4789-4794
Herein we describe further evolution of hydroxyethylamine inhibitors of BACE-1 with enhanced permeability characteristics necessary for CNS penetration. Variation at the P2' position of the inhibitor with more polar substituents led to compounds 19 a
Publikováno v:
Tetrahedron. 57:6679-6693
R , S -1-Methyl 1′-cyclopropylmethanol can be converted to its trichloroacetimidate derivative. Lewis acid catalyzed etherification can then be used to prepare methyl cyclopropylmethyl (MCPM) ethers. Thus, ethyl 2,3,4-tri- O -benzyl-6- O -( R , S -
Autor:
Paul Beroza, Michael P. Bova, Jennifer K. Hoffman, Jennifer Sealy, Heather Zhang, Marcelle Bergeron, Linnea Diep, Danny Tam, Ruth Motter, Zhao Ren, R. Jeffrey Neitz, Danielle L. Aubele, Kent Fitzgerald, Michael Ye, Wayman Chan, Pearl Tanaka, Deepal Pandya, Donald J. Fauss, Andrei W. Konradi, John P. Anderson, Roy K. Hom, Dean R. Artis, Hing L. Sham, Robert A. Galemmo, George Tonn, Jeanne Baker, Lany Ruslim, Yong L. Zhu, Anh P. Truong, Michael S. Dappen, Simeon Bowers
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(9)
Polo-like kinase-2 (Plk-2) is a potential therapeutic target for Parkinson’s disease and this Letter describes the SAR of a series of dihydropteridinone based Plk-2 inhibitors. By optimizing both the N-8 substituent and the biaryl region of the inh
Autor:
Nanhua Yao, Hing L. Sham, Hu Pan, Zhao Ren, Ted Yednock, Simeon Bowers, Gergely Toth, Louis Brogley, Anh P. Truong, Jing Wu, Martin L. Neitzel, Kevin P. Quinn, Frederique Bard, John-Michael Sauer, Dean R. Artis, Jennifer Sealy, Larry Fang, Kyle Powell, Gary Probst, Irene Griswold-Prenner, R. Jeffrey Neitz, Andrei W. Konradi, Roy K. Hom
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(24)
From high throughput screening, we discovered compound 1, the prototype for a series of disubstituted thiophene inhibitors of JNK which is selective towards closely related MAP kinases p38 and Erk2. Herein we describe the evolution of these compounds
Autor:
Jay S. Tung, Nanhua Yao, Shawn Gauby, Kevin P. Quinn, May Lin, Lany Ruslim, Jennifer Sealy, Michael A. Pleiss, Luke Tso, John A. Tucker, Hu Pan, Gergely Toth, Sukanto Sinha, Andrei W. Konradi, Varghese John, Ying-Zi Xu, Anh P. Truong, Darren B. Dressen, Wes Zmolek, Gary Probst, Hing L. Sham, Eric Brecht, Jagodzinska Barbara, Jacek Jagodzinski, Michael P. Bova, Simeon Bowers, Roy K. Hom, John-Michael Sauer, Dean R. Artis, Brian P. Stupi, Ted Yednock, Andrea Gailunas, Jose Aquino
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(20)
The structure-activity relationship of the prime region of hydroxyethylamine BACE inhibitors is described. Variation in the aryl linker region with 5- and 6-membered heterocycles provided compounds such as 33 with improved permeability and reduced P-
Publikováno v:
Sexually transmitted diseases. 28(9)
The percentage of Neisseria gonorrhoeae isolates resistant to antimicrobial agents commonly used for treatment is unknown in many Caribbean countries.To determine the antimicrobial susceptibility of N gonorrhoeae isolates from Trinidad (144 isolates)
Publikováno v:
The Journal of biological chemistry. 272(2)
DmpK from Pseudomonas sp. strain CF600 represents a group of proteins required by phenol-degrading bacteria that utilize a multicomponent iron-containing phenol hydroxylase. DmpK has been overexpressed in Escherichia coli and purified to homogeneity;