Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jennifer S. Shapiro"'
Autor:
Eric A. Price, Adam J. Simon, Jennifer S. Shapiro, Sethu Sankaranarayanan, Mark Stiteler, Guoxin Wu
Publikováno v:
Journal of Neuroscience Methods. 205:36-44
Cerebrospinal fluid (CSF) provides a window into central nervous system (CNS) physiology and pathophysiology in human neurodegenerative conditions such as Alzheimer's disease. Changes in CSF bioanalytes also provide a direct readout of target engagem
Autor:
Mitchell A. Lazar, A. Sophie Rich, Ben Rhoades, Jennifer S. Shapiro, Jason K. Kim, Klaus H. Kaestner, Shamina M. Rangwala, Gerald I. Shulman
Publikováno v:
Developmental Cell. 5:657-663
Obesity-associated diabetes is epidemic in industrialized societies. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) is highly expressed in adipose tissue and the presumed molecular target for antidiabetic thiazolidi
Publikováno v:
Diabetes. 55(6)
Conjugated linoleic acids (CLAs) are conjugated dienoic isomers of linoleic acid. Many people supplement their diets with CLAs to attempt weight loss, and the trans-10,cis-12 isomer (t10,c12-CLA) of CLA reduces adiposity in animal models and humans.
Autor:
Mitchell A. Lazar, Ben Rhoades, A. Sophie Rich, Shamina M. Rangwala, Luciano Rossetti, Silvana Obici, Jennifer S. Shapiro
Publikováno v:
Diabetes. 53(8)
Resistin is an adipocyte-secreted protein that circulates at increased levels in obesity. Acute administration of resistin impairs glucose tolerance, but the effects of chronic hyperresistinemia have not been established. Here we describe the generat
Autor:
Ben Rhoades, Juan Wang, Ronadip R. Banerjee, Yong Qi, Jennifer S. Shapiro, Alessandro Pocai, Silvana Obici, A. Sophie Rich, Michael W. Rajala, Mitchell A. Lazar, Phillipp E. Scherer, Claire M. Steppan, Shamina M. Rangwala, Luciano Rossetti, Rexford S. Ahima
Publikováno v:
Science (New York, N.Y.). 303(5661)
The association between obesity and diabetes supports an endocrine role for the adipocyte in maintaining glucose homeostasis. Here we report that mice lacking the adipocyte hormone resistin exhibit low blood glucose levels after fasting, due to reduc