Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jennifer S. Downey"'
Dissecting the Role of VicK Phosphatase in Aggregation and Biofilm Formation of Streptococcus mutans
Autor:
Jennifer S. Downey, Xian Peng, Youping Li, Steven D. Goodman, T Tao, Y Qiu, Xuedong Zhou, X Yang, D B Senadheera, Dennis G. Cvitkovitch, L Long, Aidong Han, Suping Wang
Publikováno v:
Journal of Dental Research. 100:631-638
VicRK (WalRK or YycFG) is a conserved 2-component regulatory system (TCS) that regulates cell division, cell wall biosynthesis, and homeostasis in low-GC Gram-positive bacteria. VicRK is also associated with biofilm formation of Streptococcus mutans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a093a65bd47b5758ca9cb57037b31aad
https://doi.org/10.1177/0022034520979798
https://doi.org/10.1177/0022034520979798
Autor:
Jennifer S Downey, Lauren Mashburn-Warren, Eduardo A Ayala, Dilani B Senadheera, Whitney K Hendrickson, Lathan W McCall, Julie G Sweet, Dennis G Cvitkovitch, Grace A Spatafora, Steven D Goodman
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115975 (2014)
Streptococcus mutans, a major acidogenic component of the dental plaque biofilm, has a key role in caries etiology. Previously, we demonstrated that the VicRK two-component signal transduction system modulates biofilm formation, oxidative stress and
Externí odkaz:
https://doaj.org/article/074321a61e3e469db39631097996633a
Autor:
Eduardo Ayala, Jennifer S Downey, Lauren Mashburn-Warren, Dilani B Senadheera, Dennis G Cvitkovitch, Steven D Goodman
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108027 (2014)
Two-component systems (TCSs) are ubiquitous among bacteria and are among the most elegant and effective sensing systems in nature. They allow for efficient adaptive responses to rapidly changing environmental conditions. In this study, we investigate
Externí odkaz:
https://doaj.org/article/5e16dd152ea54d518a719a17d84f6e40
Autor:
Chen Wang, Jiayan Sang, Jiawei Wang, Mingyan Su, Jennifer S Downey, Qinggan Wu, Shida Wang, Yongfei Cai, Xiaozheng Xu, Jun Wu, Dilani B Senadheera, Dennis G Cvitkovitch, Lin Chen, Steven D Goodman, Aidong Han
Publikováno v:
PLoS Biology, Vol 11, Iss 2, p e1001493 (2013)
Two-component systems (TCSs) are important for the adaptation and survival of bacteria and fungi under stress conditions. A TCS is often composed of a membrane-bound sensor histidine kinase (SK) and a response regulator (RR), which are relayed throug
Externí odkaz:
https://doaj.org/article/2209811eb85f41de96bc1fa2ffe496cb
Autor:
Sheryl S Justice, Birong Li, Jennifer S Downey, Shareef M Dabdoub, M Elizabeth Brockson, G Duane Probst, William C Ray, Steven D Goodman
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48349 (2012)
Uropathogenic Escherichia coli (UPEC) utilizes a complex community-based developmental pathway for growth within superficial epithelial cells of the bladder during cystitis. Extracellular DNA (eDNA) is a common matrix component of organized bacterial
Externí odkaz:
https://doaj.org/article/00b9b3cc220c41c98c343084051a7ffc
Publikováno v:
Molecular Oral Microbiology.
Summary Streptococcus mutans is recognized as one of the key contributors to the dysbiotic state that results in dental caries. While existing treatment strategies reduce the incidence of tooth decay, they also eliminate both the cariogenic and benef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0467d2df13820f30e43075a5e7c3914
https://doi.org/10.1111/omi.12186
https://doi.org/10.1111/omi.12186
Autor:
Wenyuan Shi, David C. I. Hung, Steven D. Goodman, Fengxia Qi, Jens Kreth, Dennis G. Cvitkovitch, Jennifer S. Downey
Publikováno v:
Journal of Bacteriology. 194:1127-1135
We have previously characterized the interactions of the response regulator ComE from Streptococcus mutans and DNA binding sites through DNase I footprinting and electrophoretic mobility shift assay analysis. Since response regulator functions are of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b8af51443db08c43271d9817aaa345
https://doi.org/10.1128/jb.06565-11
https://doi.org/10.1128/jb.06565-11
Autor:
Steven D. Goodman, Jennifer S. Downey, Lauren O. Bakaletz, Birong Li, Laura A. Novotny, Sheryl S. Justice, Joseph A. Jurcisek, Eduardo A. Ayala, Natalia O. Tjokro, Kyle P. Obergfell
Publikováno v:
Mucosal Immunology. 4:625-637
Bacteria that cause chronic and/or recurrent diseases often rely on a biofilm lifestyle. The foundation of the biofilm structure is the extracellular polymeric substance (EPS) that acts as a barrier to both effectors of the immune system and antimicr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c96ad6b78c16d55a99b3d0824dc625
https://doi.org/10.1038/mi.2011.27
https://doi.org/10.1038/mi.2011.27
Publikováno v:
Analytical Biochemistry. 415:21-26
Gene synthesis is a convenient tool that is widely used to make genes for a variety of purposes. All current protocols essentially take inside-out approaches to assemble complete genes using DNA oligonucleotides or intermediate fragments. Here we pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415c333cdc5612e1c688e883676381e0
https://doi.org/10.1016/j.ab.2011.04.004
https://doi.org/10.1016/j.ab.2011.04.004
Autor:
Chenggang Wu, Eduardo A. Ayala, Steven D. Goodman, Jennifer S. Downey, Justin Merritt, Fengxia Qi
Publikováno v:
Journal of Bacteriology. 192:4669-4679
The ciaRH operon in Streptococcus mutans contains 3 contiguous genes, ciaXRH . Unlike the CiaRH system in other streptococci, only the ciaH -null mutant displays defective phenotypes, while the ciaR -null mutant behaves like the wild type. The object
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2d22eb7c35857a5e1cafce41dd9ac7
https://doi.org/10.1128/jb.00556-10
https://doi.org/10.1128/jb.00556-10