Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Jennifer S Yokoyama"'
Autor:
Iris Broce, Celeste M Karch, Natalie Wen, Chun C Fan, Yunpeng Wang, Chin Hong Tan, Naomi Kouri, Owen A Ross, Günter U Höglinger, Ulrich Muller, John Hardy, International FTD-Genomics Consortium, Parastoo Momeni, Christopher P Hess, William P Dillon, Zachary A Miller, Luke W Bonham, Gil D Rabinovici, Howard J Rosen, Gerard D Schellenberg, Andre Franke, Tom H Karlsen, Jan H Veldink, Raffaele Ferrari, Jennifer S Yokoyama, Bruce L Miller, Ole A Andreassen, Anders M Dale, Rahul S Desikan, Leo P Sugrue
Publikováno v:
PLoS Medicine, Vol 15, Iss 1, p e1002504 (2018)
[This corrects the article DOI: 10.1371/journal.pmed.1002487.].
Externí odkaz:
https://doaj.org/article/68e0835f1cc24c9d9684e7af326cdf30
Autor:
Iris Broce, Celeste M Karch, Natalie Wen, Chun C Fan, Yunpeng Wang, Chin Hong Tan, Naomi Kouri, Owen A Ross, Günter U Höglinger, Ulrich Muller, John Hardy, International FTD-Genomics Consortium, Parastoo Momeni, Christopher P Hess, William P Dillon, Zachary A Miller, Luke W Bonham, Gil D Rabinovici, Howard J Rosen, Gerard D Schellenberg, Andre Franke, Tom H Karlsen, Jan H Veldink, Raffaele Ferrari, Jennifer S Yokoyama, Bruce L Miller, Ole A Andreassen, Anders M Dale, Rahul S Desikan, Leo P Sugrue
Publikováno v:
PLoS Medicine, Vol 15, Iss 1, p e1002487 (2018)
BackgroundConverging evidence suggests that immune-mediated dysfunction plays an important role in the pathogenesis of frontotemporal dementia (FTD). Although genetic studies have shown that immune-associated loci are associated with increased FTD ri
Externí odkaz:
https://doaj.org/article/598076bfb75043e49e412ef915402c56
Autor:
Natasha Z R Steele, Jessie S Carr, Luke W Bonham, Ethan G Geier, Vincent Damotte, Zachary A Miller, Rahul S Desikan, Kevin L Boehme, Shubhabrata Mukherjee, Paul K Crane, John S K Kauwe, Joel H Kramer, Bruce L Miller, Giovanni Coppola, Jill A Hollenbach, Yadong Huang, Jennifer S Yokoyama
Publikováno v:
PLoS Medicine, Vol 14, Iss 3, p e1002272 (2017)
BackgroundAlzheimer disease (AD) is a progressive disorder that affects cognitive function. There is increasing support for the role of neuroinflammation and aberrant immune regulation in the pathophysiology of AD. The immunoregulatory human leukocyt
Externí odkaz:
https://doaj.org/article/f71e760be1ec49f9bf26347ba7290f7c
Autor:
Rahul S Desikan, Chun Chieh Fan, Yunpeng Wang, Andrew J Schork, Howard J Cabral, L Adrienne Cupples, Wesley K Thompson, Lilah Besser, Walter A Kukull, Dominic Holland, Chi-Hua Chen, James B Brewer, David S Karow, Karolina Kauppi, Aree Witoelar, Celeste M Karch, Luke W Bonham, Jennifer S Yokoyama, Howard J Rosen, Bruce L Miller, William P Dillon, David M Wilson, Christopher P Hess, Margaret Pericak-Vance, Jonathan L Haines, Lindsay A Farrer, Richard Mayeux, John Hardy, Alison M Goate, Bradley T Hyman, Gerard D Schellenberg, Linda K McEvoy, Ole A Andreassen, Anders M Dale
Publikováno v:
PLoS Medicine, Vol 14, Iss 3, p e1002258 (2017)
BackgroundIdentifying individuals at risk for developing Alzheimer disease (AD) is of utmost importance. Although genetic studies have identified AD-associated SNPs in APOE and other genes, genetic information has not been integrated into an epidemio
Externí odkaz:
https://doaj.org/article/14159604a7684d2ca1b93c7c8aca5c2f
Autor:
Daniel W. Sirkis, Alexis P. Oddi, Caroline Jonson, Luke W. Bonham, Phuong T. Hoang, Jennifer S. Yokoyama
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
Recent advances in transcriptomics research have uncovered heightened interferon (IFN) responses in neurodegenerative diseases including Alzheimer’s disease, primary tauopathy, Parkinson’s disease, TDP-43 proteinopathy, and related mouse models.
Externí odkaz:
https://doaj.org/article/341f8054296f419f8c7366289f3e0a39
Autor:
Jennifer S Yokoyama, Allen K L Lee, Leonel T Takada, Edgar Busovaca, Luke W Bonham, Steven Z Chao, Marian Tse, Jing He, Christopher G Schwarz, Owen T Carmichael, Brandy R Matthews, Anna Karydas, Michael W Weiner, Giovanni Coppola, Charles S DeCarli, Bruce L Miller, Howard J Rosen
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118338 (2015)
Studying ethnically diverse groups is important for furthering our understanding of biological mechanisms of disease that may vary across human populations. The ε4 allele of apolipoprotein E (APOE ε4) is a well-established risk factor for Alzheimer
Externí odkaz:
https://doaj.org/article/7bea0dcb2ab04fc9befe88c99671dc1b
Autor:
Jennifer S Yokoyama, Ernest T Lam, Alison L Ruhe, Carolyn A Erdman, Kathryn R Robertson, Aubrey A Webb, D Colette Williams, Melanie L Chang, Marjo K Hytönen, Hannes Lohi, Steven P Hamilton, Mark W Neff
Publikováno v:
PLoS Genetics, Vol 8, Iss 9, p e1002898 (2012)
Domestic dogs can suffer from hearing losses that can have profound impacts on working ability and quality of life. We have identified a type of adult-onset hearing loss in Border Collies that appears to have a genetic cause, with an earlier age of o
Externí odkaz:
https://doaj.org/article/788811827fc345669a1236be5f10233a
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10809 (2010)
Genome-wide association scans for genetic loci underlying both Mendelian and complex traits are increasingly common in canine genetics research. However, the demand for high-quality DNA for use on such platforms creates challenges for traditional blo
Externí odkaz:
https://doaj.org/article/9e9f6db4a4634bc9b32e6b677e3fde50
Autor:
Daniel W. Sirkis, Caroline Warly Solsberg, Taylor P. Johnson, Luke W. Bonham, Virginia E. Sturm, Suzee E. Lee, Katherine P. Rankin, Howard J. Rosen, Adam L. Boxer, William W. Seeley, Bruce L. Miller, Ethan G. Geier, Jennifer S. Yokoyama
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-22 (2023)
Abstract Background Emerging evidence from mouse models is beginning to elucidate the brain’s immune response to tau pathology, but little is known about the nature of this response in humans. In addition, it remains unclear to what extent tau path
Externí odkaz:
https://doaj.org/article/593d8cbdd12d4eee9bf2368860ac1c9f
Autor:
Iris J. Broce, Daniel W. Sirkis, Ryan M. Nillo, Luke W. Bonham, Suzee E. Lee, Bruce L. Miller, Patricia A. Castruita, Virginia E. Sturm, Leo S. Sugrue, Rahul S. Desikan, Jennifer S. Yokoyama
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionA hexanucleotide repeat expansion (HRE) intronic to chromosome 9 open reading frame 72 (C9orf72) is recognized as the most common genetic cause of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and ALS-FTD. Identifyin
Externí odkaz:
https://doaj.org/article/b13a9c462df547a2b3c345568ced924f