Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jennifer S Pfingsten"'
Publikováno v:
PLoS ONE, Vol 3, Iss 9, p e3242 (2007)
A single internal ribosomal entry site (IRES) in conjunction with IRES transactivating factors (ITAFs) is sufficient to recruit the translational machinery to a eukaryotic mRNA independent of the cap structure. However, we demonstrate that the mouse
Externí odkaz:
https://doaj.org/article/3cc17d664c6c472ba033c889a0858f29
Publikováno v:
RNA. 14:1255-1263
In eukaryotes, the canonical process of initiating protein synthesis on an mRNA depends on many large protein factors and the modified nucleotide cap on the 5′ end of the mRNA. However, certain RNA sequences can bypass the need for these proteins a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db11683b42798608e2ffdee6773c03f
https://doi.org/10.1261/rna.987808
https://doi.org/10.1261/rna.987808
Publikováno v:
Journal of Molecular Biology. 370:856-869
Internal ribosome entry site (IRES) RNAs are necessary for successful infection of many pathogenic viruses, but the details of the RNA structure-based mechanism used to bind and manipulate the ribosome remain poorly understood. The IRES RNAs from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd0cacfaada73349edeef2054290194
https://doi.org/10.1016/j.jmb.2007.04.076
https://doi.org/10.1016/j.jmb.2007.04.076
Publikováno v:
Science. 314:1450-1454
Canonical cap-dependent translation initiation requires a large number of protein factors that act in a stepwise assembly process. In contrast, internal ribosomal entry sites (IRESs) are cis -acting RNAs that in some cases completely supplant these f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e22d23b0dacecdb22dafa867a4f835d1
https://doi.org/10.1126/science.1133281
https://doi.org/10.1126/science.1133281
Publikováno v:
RNA (New York, N.Y.). 19(6)
Most nucleic acid-binding proteins selectively bind either DNA or RNA, but not both nucleic acids. The Saccharomyces cerevisiae Ku heterodimer is unusual in that it has two very different biologically relevant binding modes: (1) Ku is a sequence-nons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de95fa37ebf47b24bd67ee6b0738bd4
https://pubmed.ncbi.nlm.nih.gov/23610127
https://pubmed.ncbi.nlm.nih.gov/23610127
Autor:
Thomas R. Cech, Pascal Chartrand, Karen J. Goodrich, Cornelius Y. Taabazuing, Faissal Ouenzar, Jennifer S. Pfingsten
Publikováno v:
Cell. 148(5)
Summary In Saccharomyces cerevisiae , the Ku heterodimer contributes to telomere maintenance as a component of telomeric chromatin and as an accessory subunit of telomerase. How Ku binding to double-stranded DNA (dsDNA) and to telomerase RNA (TLC1) p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af44db078aacbf44c4e961ec672a9235
https://pubmed.ncbi.nlm.nih.gov/22365814
https://pubmed.ncbi.nlm.nih.gov/22365814
The Dicistroviridae intergenic region (IGR) internal ribosome entry site (IRES) RNAs drive a cap-independent pathway of translation initiation, recruiting both the small and large ribosomal subunits to the viral RNA without the use of any canonical t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5303c784b570b678bda6afd2e1c70d2d
https://europepmc.org/articles/PMC2788014/
https://europepmc.org/articles/PMC2788014/
Publikováno v:
Methods in enzymology. 430
Internal ribosome entry sites (IRESs) substitute RNA sequences for some or all of the canonical translation initiation protein factors. Therefore, an important component of understanding IRES function is a description of the three-dimensional structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::849e830cc7e8de0419e3d0282acaebf8
https://pubmed.ncbi.nlm.nih.gov/17913644
https://pubmed.ncbi.nlm.nih.gov/17913644
Autor:
Jennifer S. Pfingsten, Jeffrey S. Kieft, John A. Hammond, David A. Costantino, Megan E. Filbin
Internal ribosome entry sites (IRESs) substitute RNA sequences for some or all of the canonical translation initiation protein factors. Therefore, an important component of understanding IRES function is a description of the three-dimensional structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d53867eb7426e79cd09c34905e0499f
https://doi.org/10.1016/s0076-6879(07)30013-x
https://doi.org/10.1016/s0076-6879(07)30013-x
Publikováno v:
Nature Structural & Molecular Biology. 12:938-939
Flock House virus protein B2 suppresses the RNA-mediated interference response by binding double-stranded RNA of almost any size or sequence. The crystal structure of this protein bound to RNA reveals a novel fold that suggests its mechanism of actio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbddea194ea9f42f0f76a89e12302275
https://doi.org/10.1038/nsmb1105-938
https://doi.org/10.1038/nsmb1105-938