Zobrazeno 1 - 10
of 478
pro vyhledávání: '"Jennifer S Brodbelt"'
Autor:
Joshua E Mayfield, Seema Irani, Edwin E Escobar, Zhao Zhang, Nathaniel T Burkholder, Michelle R Robinson, M Rachel Mehaffey, Sarah N Sipe, Wanjie Yang, Nicholas A Prescott, Karan R Kathuria, Zhijie Liu, Jennifer S Brodbelt, Yan Zhang
Publikováno v:
eLife, Vol 8 (2019)
The Positive Transcription Elongation Factor b (P-TEFb) phosphorylates Ser2 residues of the C-terminal domain (CTD) of the largest subunit (RPB1) of RNA polymerase II and is essential for the transition from transcription initiation to elongation in
Externí odkaz:
https://doaj.org/article/53e0122eb0c34ddbb874f06e2b7e518b
Autor:
Evan A. Schwartz, Jack P. K. Bravo, Mohd Ahsan, Luis A. Macias, Caitlyn L. McCafferty, Tyler L. Dangerfield, Jada N. Walker, Jennifer S. Brodbelt, Giulia Palermo, Peter C. Fineran, Robert D. Fagerlund, David W. Taylor
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract CRISPR-Cas are adaptive immune systems in bacteria and archaea that utilize CRISPR RNA-guided surveillance complexes to target complementary RNA or DNA for destruction1–5. Target RNA cleavage at regular intervals is characteristic of type
Externí odkaz:
https://doaj.org/article/df1f8e1485e54ad7bc5ecc11d0bc3d0e
Autor:
Leah M. VanOtterloo, Luis A. Macias, Matthew J. Powers, Jennifer S. Brodbelt, M. Stephen Trent
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT A fundamental feature of Gram-negative bacteria is their outer membrane that protects the cell against environmental stressors. This defense is predominantly due to its asymmetry, with glycerophospholipids located in the inner leaflet and li
Externí odkaz:
https://doaj.org/article/551303c0cc5a402fb9c522456e783b30
Autor:
Maria L. Allende, Y. Terry Lee, Colleen Byrnes, Cuiling Li, Galina Tuymetova, Jenna Y. Bakir, Elena-Raluca Nicoli, Virginia K. James, Jennifer S. Brodbelt, Cynthia J. Tifft, Richard L. Proia
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 12, Pp 100463- (2023)
GM1 gangliosidosis is a neurodegenerative disorder caused by mutations in the GLB1 gene, which encodes lysosomal β-galactosidase. The enzyme deficiency blocks GM1 ganglioside catabolism, leading to accumulation of GM1 ganglioside and asialo-GM1 gang
Externí odkaz:
https://doaj.org/article/94f9b0fdff3447668849eed7667b5c00
Autor:
Eleanor Watts, Aarti Bashyal, Sean D. Dunham, Christopher M. Crittenden, Jennifer S. Brodbelt
Publikováno v:
Antibodies, Vol 13, Iss 2, p 30 (2024)
As the development of new biotherapeutics advances, increasingly sophisticated tandem mass spectrometry methods are needed to characterize the most complex molecules, including antibody drug conjugates (ADCs). Lysine-linked ADCs, such as trastuzumab-
Externí odkaz:
https://doaj.org/article/f30a76286ca04cb885ac00aa10e1c45a
Autor:
Rosamaria Y. Moreno, Kyle J. Juetten, Svetlana B. Panina, Jamie P. Butalewicz, Brendan M. Floyd, Mukesh Kumar Venkat Ramani, Edward M. Marcotte, Jennifer S. Brodbelt, Y. Jessie Zhang
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107581- (2023)
Summary: During eukaryotic transcription, RNA polymerase II undergoes dynamic post-translational modifications on the C-terminal domain (CTD) of the largest subunit, generating an information-rich PTM landscape that transcriptional regulators bind. T
Externí odkaz:
https://doaj.org/article/508e48fd4c6846dc911d42011f3bddbf
Autor:
Amanda Helms, Jennifer S. Brodbelt
Publikováno v:
Cells, Vol 13, Iss 5, p 394 (2024)
Glycoproteomics has accelerated in recent decades owing to numerous innovations in the analytical workflow. In particular, new mass spectrometry strategies have contributed to inroads in O-glycoproteomics, a field that lags behind N-glycoproteomics d
Externí odkaz:
https://doaj.org/article/a77c317ca75649c2b7bda15813ddee4a
Autor:
Roisin E. O’Brien, Inês C. Santos, Daniel Wrapp, Jack P. K. Bravo, Evan A. Schwartz, Jennifer S. Brodbelt, David W. Taylor
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
Type I-C Cascade (the CRISPR-associated complex for antiviral defense) is a minimal system, comprising only three unique Cas proteins. Cryo-EM structure of the Desulfovibrio vulgaris type I-C Cascade reveals the molecular mechanisms that underlie RNA
Externí odkaz:
https://doaj.org/article/fc5250035c114ed7829c434b6fd80c1f
Autor:
Mary D. Cundiff, Christina M. Hurley, Jeremy D. Wong, Joseph A. Boscia, Aarti Bashyal, Jake Rosenberg, Eden L. Reichard, Nicholas D. Nassif, Jennifer S. Brodbelt, Daniel A. Kraut
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Abstract The ubiquitin-proteasome system (UPS) is responsible for the bulk of protein degradation in eukaryotic cells, but the factors that cause different substrates to be unfolded and degraded to different extents are still poorly understood. We pr
Externí odkaz:
https://doaj.org/article/88efcdeee9f84f3485e5d78c2f85812e
Autor:
Virginia K. James, James D. Sanders, Konstantin Aizikov, Kyle L. Fort, Dmitry Grinfeld, Alexander Makarov, Jennifer S. Brodbelt
Publikováno v:
Analytical Chemistry. 95:7656-7664
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09edb7133999781a5108ed8f72f6b7d3
https://doi.org/10.1021/acs.analchem.3c00594
https://doi.org/10.1021/acs.analchem.3c00594