Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jennifer S, Isaacs"'
Autor:
Eric J. Small, Charles L. Sawyers, David W. Goodrich, Richard M. White, Toby T. Hecht, Timothy C. Thompson, Rosalie C. Sears, John K. Lee, Amina Zoubeidi, William L. Dahut, Massimo Loda, Andrew M. Hruszkewycz, Tamara L. Lotan, Daniel W. Lin, Jeffrey Hildesheim, Mark A. Rubin, Jennifer S. Isaacs, Julia T. Arnold, Maria Diaz Meco, Peter S. Nelson, Charles M. Rudin, Himisha Beltran, David R. Rowley, Adam P. Dicker, Max S. Wicha, James L. Gulley, Howard I. Scher, Abdul Tawab-Amiri, Karen E. Knudsen, Michael M. Shen, Evan Y. Yu, Kathleen Kelly
Publikováno v:
Clin Cancer Res
Lineage plasticity has emerged as an important mechanism of treatment resistance in prostate cancer. Treatment-refractory prostate cancers are increasingly associated with loss of luminal prostate markers, and in many cases induction of developmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e316f254de156baa421beb322cb8dc
https://doi.org/10.1158/1078-0432.ccr-19-1423
https://doi.org/10.1158/1078-0432.ccr-19-1423
Autor:
Udhayakumar Gopal, Jessica E Bohonowych, Carla Lema-Tome, Angen Liu, Elizabeth Garrett-Mayer, Bingcheng Wang, Jennifer S Isaacs
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17649 (2011)
Extracellular Hsp90 protein (eHsp90) potentiates cancer cell motility and invasion through a poorly understood mechanism involving ligand mediated function with its cognate receptor LRP1. Glioblastoma multiforme (GBM) represents one of the most aggre
Externí odkaz:
https://doaj.org/article/c68385c383074e079e2a602d4e275895
Publikováno v:
Oncotarget
// Abdelkader Daoud 1, * , Udhayakumar Gopal 1, 2, * , Jasmine Kaur 1 and Jennifer S. Isaacs 1 1 Department of Cell and Molecular Pharmacology, Medical University of South Carolina, SC, 29412, Charleston, USA 2 Current address: Department of Patholog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeec286fa250d617212c271a5d7832e0
https://doi.org/10.18632/oncotarget.22370
https://doi.org/10.18632/oncotarget.22370
Publikováno v:
Cancers, Vol 6, Iss 2, Pp 1065-1097 (2014)
Cancers
Cancers
Heat shock proteins (Hsps) represent a diverse group of chaperones that play a vital role in the protection of cells against numerous environmental stresses. Although our understanding of chaperone biology has deepened over the last decade, the “at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad159d701ee1be6963dc9628c7b8e58
https://doi.org/10.3390/cancers6021065
https://doi.org/10.3390/cancers6021065
Autor:
Jessica E. Bohonowych, Chris Parsons, Krystal D. Nolan, Michael Defee, Michael W. Hance, Jennifer S. Isaacs
Publikováno v:
The Prostate. 74:395-407
BACKGROUND The tumor microenvironment (TME) plays an essential role in supporting and promoting tumor growth and progression. An inflammatory stroma is a widespread hallmark of the prostate TME, and prostate tumors are known to co-evolve with their r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ebb75969f47c743750e3dbab330b603
https://doi.org/10.1002/pros.22761
https://doi.org/10.1002/pros.22761
Publikováno v:
Oncotarget
// Krystal D. Nolan 1, * , Jasmine Kaur 1, * , Jennifer S. Isaacs 1 1 Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Hollings Cancer Center, Charleston, SC, USA * These authors have contributed equally to this wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246f60c455f3432f6bbeb25a4d28db52
https://pubmed.ncbi.nlm.nih.gov/28038472
https://pubmed.ncbi.nlm.nih.gov/28038472
Autor:
Carlos Torres-Cabala, Berton Zbar, Yun Jin Jung, Len Neckers, Peter J. Ratcliffe, Sunmin Lee, Jane B. Trepel, Maria J. Merino, Jennifer S. Isaacs, David R. Mole, Yuen-Li Chung, Jorge R. Toro, W. Marston Linehan
SummaryIndividuals with hemizygous germline fumarate hydratase (FH) mutations are predisposed to renal cancer. These tumors predominantly exhibit functional inactivation of the remaining wild-type allele, implicating FH inactivation as a tumor-promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186635f1ace79e5cc24790060447dcda
https://doi.org/10.1016/j.ccr.2005.06.017
https://doi.org/10.1016/j.ccr.2005.06.017
Autor:
Jennifer S, Isaacs
Publikováno v:
Advances in cancer research. 129
The cellular functions of Hsp90 have historically been attributed to its ability to chaperone client proteins involved in signal transduction. Although numerous stimuli and the signaling cascades they activate contribute to cancer progression, many o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f37f1aa87b61a7af3ef5a9cd5b1cdc9a
https://pubmed.ncbi.nlm.nih.gov/26916003
https://pubmed.ncbi.nlm.nih.gov/26916003
Autor:
Jennifer S. Isaacs
The cellular functions of Hsp90 have historically been attributed to its ability to chaperone client proteins involved in signal transduction. Although numerous stimuli and the signaling cascades they activate contribute to cancer progression, many o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e79f172a08fb4a159bb8c4d5b17c7b3
https://doi.org/10.1016/bs.acr.2015.09.003
https://doi.org/10.1016/bs.acr.2015.09.003
Autor:
Haibo Liu, Isla P. Garraway, Jessica E. Bohonowych, Carola A. Neumann, Krystal Dole, Udhayakumar Gopal, Jennifer S. Isaacs, Michael W. Hance, Agnieszka Jezierska-Drutel
Publikováno v:
Journal of Biological Chemistry. 287:37732-37744
Prostate cancer (PCa) is the most frequently diagnosed malignancy in men, and the second highest contributor of male cancer related lethality. Disease mortality is due primarily to metastatic spread, highlighting the urgent need to identify factors i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c87bc36aa417c69eab6c119c5d607d
https://doi.org/10.1074/jbc.m112.389015
https://doi.org/10.1074/jbc.m112.389015