Výsledky vyhledávání - "Jennifer Rynne"

Akademický článek

Changes in Phenotypic and Molecular Features of Naïve and Central Memory T Helper Cell Subsets following SARS-CoV-2 Vaccination

Autor: Mia Mosavie, Jennifer Rynne, Matthew Fish, Peter Smith, Aislinn Jennings, Shivani Singh, Jonathan Millar, Heli Harvala, Ana Mora, Fotini Kaloyirou, Alexandra Griffiths, Valerie Hopkins, Charlotte Washington, Lise J. Estcourt, David Roberts, Manu Shankar-Hari

Publikováno v: Vaccines, Vol 12, Iss 9, p 1040 (2024)

Molecular changes in lymphocytes following SARS-CoV-2 vaccination are incompletely understood. We hypothesized that studying the molecular (transcriptomic, epigenetic, and T cell receptor (TCR) repertoire) changes in CD4+ T cells following SARS-CoV-2

Externí odkaz: https://doaj.org/article/b9aa3ec877b240a59a25b8880a77c908

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Akademický článek

The RNA binding proteins ZFP36L1 and ZFP36L2 are dysregulated in airway epithelium in human and a murine model of asthma

Autor: Jennifer Rynne, Elena Ortiz-Zapater, Dustin C. Bagley, Onofrio Zanin, George Doherty, Varsha Kanabar, Jon Ward, David J. Jackson, Maddy Parsons, Jody Rosenblatt, Ian M. Adcock, Rocio T. Martinez-Nunez

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Introduction: Asthma is the most common chronic inflammatory disease of the airways. The airway epithelium is a key driver of the disease, and numerous studies have established genome-wide differences in mRNA expression between health and asthma. How

Externí odkaz: https://doaj.org/article/025cfd2596af4524902ab41889482181

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Akademický článek

Comparison of systemic inflammatory profiles in COVID-19 and community-acquired pneumonia patients: a prospective cohort study

Autor: Elsa D. Ibáñez-Prada, Matthew Fish, Yuli V. Fuentes, Ingrid G. Bustos, Cristian C. Serrano-Mayorga, Julian Lozada, Jennifer Rynne, Aislinn Jennings, Ana M. Crispin, Ana Maria Santos, John Londoño, Manu Shankar-Hari, Luis Felipe Reyes

Publikováno v: Respiratory Research, Vol 24, Iss 1, Pp 1-10 (2023)

Abstract Background Inflammatory responses contribute to tissue damage in COVID-19 and community-acquired pneumonia (CAP). Although predictive values of different inflammatory biomarkers have been reported in both, similarities and differences of inf

Externí odkaz: https://doaj.org/article/707de43947e3479da7b9957ce076ca1c

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The RNA binding proteins ZFP36L1 and ZFP36L2 modulate transcriptional and post-transcriptional genome-wide effects of glucocorticoids

Autor: Jennifer Rynne, Elena Ortiz-Zapater, Paniz Khooshemehri, Nicole O. Ponde, Giselda Bucca, Andrew Hesketh, Manuela Platé, Rachel Chambers, Colin Smith, Rocio T. Martinez-Nunez

Glucocorticoids (GCs) are one of the most used anti-inflammatory drugs worldwide. Despite their widespread use, our understanding of their post-transcriptional effects remains poorly understood. The tristetraprolin (TTP) RNA binding protein (RBP) fam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ffd508aa9a1b101852bfb12272e0459
https://doi.org/10.1101/2022.09.27.509553

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Compartmentalisation of immune responses in critical illness: does it matter?

Autor: Andrew Conway Morris, Jennifer Rynne, Manu Shankar-Hari

Critical illness is pragmatically defined as an acute illness resulting in organ dysfunction, necessitating organ support in specialised settings (intensive care units), to survive1. Despite current best care, ~30% of patients die within 30-days from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298b9eff5f74579aa30963a1705d0819
https://www.repository.cam.ac.uk/handle/1810/340458

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Virological Characterization of Critically Ill Patients With COVID-19 in the United Kingdom: Interactions of Viral Load, Antibody Status, and B.1.1.7 Infection

Publikováno v: 2021, ' Virological Characterization of Critically Ill Patients With COVID-19 in the United Kingdom : Interactions of Viral Load, Antibody Status, and B.1.1.7 Infection ', The Journal of Infectious Diseases, vol. 224, no. 4, pp. 595-605 . https://doi.org/10.1093/infdis/jiab283

BackgroundConvalescent plasma containing neutralizing antibody to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is under investigation for coronavirus disease 2019 (COVID-19) treatment. We report diverse virological characteristics of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3935a99113299cb16abdecddfb35876e
https://doi.org/10.1093/infdis/jiab283

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