Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jennifer Rock Klotz"'
Autor:
Julio C. Chavez, Eric Padron, Mohamed A. Kharfan-Dabaja, Gabriela Corrales-Yepez, Najla Alali, Rami S. Komrokji, Jennifer Rock-Klotz, Jose D Sandoval-Sus, Samir Dalia, Javier Pinilla-Ibarz
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 15:S14-S18
Patients with chronic lymphocytic leukemia (CLL) have a 2- to 5-fold risk of developing a second malignancy compared with the general population. The incidence of myeloid malignancies, such as acute myeloid leukemia and myelodysplastic syndrome, is i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6878c3e57bad8e41864bfd441258ee
https://doi.org/10.1016/j.clml.2015.03.013
https://doi.org/10.1016/j.clml.2015.03.013
Autor:
Fengdong Cheng, Calvin Lee, Patricio Perez-Villarroel, Alejandro Villagra, Jay H. Kalin, Jennifer Rock-Klotz, Maritza Lienlaf, Wayne W. Hancock, Jianguo Tao, Edward Seto, Karrune Woan, Eduardo M. Sotomayor, Hongwei Wang, Javier Pinilla-Ibarz, Alan P. Kozikowski, David M. Woods, Eva Sahakian
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 193(6)
APCs are critical in T cell activation and in the induction of T cell tolerance. Epigenetic modifications of specific genes in the APC play a key role in this process, and among them histone deacetylases (HDACs) have emerged as key participants. HDAC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de9ad2998fa9730d37cacd69be0c1f2
https://pubmed.ncbi.nlm.nih.gov/25108026
https://pubmed.ncbi.nlm.nih.gov/25108026
Autor:
Jie Chen, David M. Woods, Eva Sahakian, Eduardo M. Sotomayor, John Powers, Jennifer Rock-Klotz, Fengdong Cheng, Alejandro Villagra, Karrune Woan, Je In Youn, Dmitry I. Gabrilovich, Allison Distler, Susan L. Deng, Andressa L. Sodre, Javier Pinilla-Ibarz
Publikováno v:
Molecular immunology. 63(2)
Myeloid-derived suppressor cells (MDSC's), a heterogeneous population of cells capable of suppressing anti-tumor T cell function in the tumor microenvironment, represent an imposing obstacle in the development of cancer immunotherapeutics. Thus, iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974d8b7e5574a6f0e8a1339e73c71d49
https://pubmed.ncbi.nlm.nih.gov/25155994
https://pubmed.ncbi.nlm.nih.gov/25155994
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 15:S207-S208
in relapsed/refractory (R/R) CLL. Ofatumumab, an anti-CD20 antibody, has activity in combination with chemotherapy in CLL. Objective: Evaluate safety and activity of ibrutinib combined with ofatumumab (phase Ib/II) in 3 different sequences. Patients:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6057c65ff140e44fd272425362790e0b
https://doi.org/10.1016/j.clml.2015.04.070
https://doi.org/10.1016/j.clml.2015.04.070
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 15:S205-S206
Background: NOTCH1 mutations have been identified as a poor prognostic biomarker associated with a more aggressive phenotype, increased rate of Richter’s transformation, and decreased response to FCR chemotherapy in high-risk patients with Chronic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ba2b2f5095d4337a83b6fc5b176cb71
https://doi.org/10.1016/j.clml.2015.04.067
https://doi.org/10.1016/j.clml.2015.04.067
Autor:
Fengdong Cheng, Karrune Woan, Oscar Merino, Ildefonso Vicente-Suarez, Alejandro Villagra, Eva Sahakian, Javier Pinilla-Ibarz, Jennifer Rock-Klotz, Edward Seto, Kenneth L. Wright, Hongwei Wang, Kapil N. Bhalla, Eduardo M. Sotomayor
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 186(7)
APCs are important in the initiation of productive Ag-specific T cell responses and the induction of T cell anergy. The inflammatory status of the APC at the time of encounter with Ag-specific T cells plays a central role in determining such divergen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9317f96a69e09a48b6f8aa20265125f3
https://pubmed.ncbi.nlm.nih.gov/21368229
https://pubmed.ncbi.nlm.nih.gov/21368229
Autor:
Javier Pinilla-Ibarz, Rami S. Komrokji, Elyce P. Turba, Samir Dalia, Lisa Nodzon, Julio C. Chavez, Mohamed A. Kharfan-Dabaja, Jennifer Rock-Klotz, Frederick L. Locke, Celeste M. Bello
Publikováno v:
Blood. 126:2941-2941
Background: With the introduction of new targeted drugs for the treatment of CLL, a new therapeutic paradigm is emerging where chemo-immunotherapy is being replaced by newer non-chemotherapy containing regimens with the goal to maintain long term res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1548feaa6eacef38e85c128111db2171
https://doi.org/10.1182/blood.v126.23.2941.2941
https://doi.org/10.1182/blood.v126.23.2941.2941
Autor:
Yibo Li, Pedro Horna, Michael Montejo, Rami S. Komrokji, Christopher Salamanca, Janice Bennett, Rebecca Levy, Barbara Williams, Lubomir Sokol, Christa Roe, Ernesto Ayala, Lewis F Glass, Elyce P. Turba, Sem Bastien, Jennifer Rock-Klotz, Farrah Farquharson
Publikováno v:
Blood. 126:1546-1546
Background Sézary syndrome (SS) is a rare malignant T-cell lymphoproliferative disorder derived from mature CD4+ T-helper/inducer cells. Patients (pts) with SS usually manifest with generalized erythroderma, peripheral blood and lymph node involveme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eac25d1ddc15ddd72330671bb4277829
https://doi.org/10.1182/blood.v126.23.1546.1546
https://doi.org/10.1182/blood.v126.23.1546.1546
Autor:
Gabriela Corrales-Yepez, Jennifer Gemmer, Jennifer Rock-Klotz, Javier Pinilla-Ibarz, Julio C. Chavez
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 15:S205
Background: CLL is a heterogeneous disease and prognosis is driven by different clinical and biological factors. The IGVH mutational status and the presence of cytogenetic abnormalities are the strongest predictors of outcome. Mutated IGVH and deleti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::481ca8c558ba900145b30a9f3e4b982b
https://doi.org/10.1016/j.clml.2015.04.066
https://doi.org/10.1016/j.clml.2015.04.066
Autor:
Jie Chen, John Powers, Jennifer Rock-Klotz, Susan Deng, Allison Distler, Fengdong Cheng, Alejandro Villagra, Eduardo M. Sotomayor, Eva Sahakian, Javier Pinilla-Ibarz
Publikováno v:
Blood. 122:4887-4887
Immature myeloid cells (IMCs) differentiate into dendritic cells, macrophages, and neutrophilsand are also considered to be precursors of MDSCs in tumor-bearing hosts. Recent studies suggest that the transcription factor CCAAT-enhancer-binding protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cdf9412efd9edad2384cfacaefae489
https://doi.org/10.1182/blood.v122.21.4887.4887
https://doi.org/10.1182/blood.v122.21.4887.4887