Výsledky vyhledávání - "Jennifer Ritchie"

Covalent inhibition by a natural product-inspired latent electrophile

Autor: David P Byun, Jennifer Ritchie, Ronald Holewinski, Hong-Rae Kim, Ravichandra Tagirasa, Joseph Ivanic, Claire M Weekley, Michael W Parker, Thorkell Adresson, Euna Yoo

Strategies to target specific protein cysteines are critical to covalent probe and drug discovery. 3-bromo-4,5-dihydroxazole is a natural product-inspired, synthetically accessible electrophilic moiety that has previously been shown to react with nuc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db0e3a69c62fcf2c60869126662eedf5
https://doi.org/10.1101/2023.01.16.524242

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Positional cloning of a quantitative trait locus contributing to pain sensitivity: possible mediation by Tyrp1

Autor: Emil Skamene, M. Gagne, Eduardo Diez, Anny Fortin, Marie-Pierre Dubé, Jennifer Ritchie, Jeffrey S. Mogil, Susana G. Sotocinal, O. Paquette

Publikováno v: Genes, Brain and Behavior. 9:856-867

To identify novel pain-relevant genes, a set of 35 recombinant congenic strains derived from the sensitive C57BL/6 and resistant A/J strains were tested for their sensitivity to noxious heat on the radiant heat paw-withdrawal test. Nine strains were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458fb1b632c859ffec58cb59a8125992
https://doi.org/10.1111/j.1601-183x.2010.00618.x

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Hypolocomotion, Asymmetrically Directed Behaviors (Licking, Lifting, Flinching, and Shaking) and Dynamic Weight Bearing (Gait) Changes are Not Measures of Neuropathic Pain in Mice

Autor: Gary J. Bennett, Jean-Sebastien Austin, Allyson C. Graham, Sara F Hughes, Jennifer Ritchie, Dale J. Langford, Jeffrey S. Mogil, Ara Schorscher-Petcu

Publikováno v: Molecular Pain, Vol 6, Iss 1, p 34 (2010)
Molecular Pain

Background: Spontaneous (non-evoked) pain is a major clinical symptom of neuropathic syndromes, one that is understudied in basic pain research for practical reasons and because of a lack of consensus over precisely which behaviors reflect spontaneou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e6418c8f173f2cedd0953d45afb616
https://doi.org/10.1186/1744-8069-6-34

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Gnao1 (GαO protein) is a likely genetic contributor to variation in physical dependence on opioids in mice

Autor: Shad B. Smith, Jean-Sebastien Austin, Jennifer Ritchie, Anny Fortin, Grace C. Rossi, Ara Schorscher-Petcu, Gad Klein, Jeffrey S. Mogil, Benjamin Kest

Publikováno v: Neuroscience. 162:1255-1264

Chronic exposure to opioids leads to physical dependence, which manifests as the symptoms of drug withdrawal. Interindividual differences in withdrawal symptom severity are well known, and at least partially due to genetic variation. To identify gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c076405b1533ba274186cd793901dd0
https://doi.org/10.1016/j.neuroscience.2009.05.027

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Relationship of Substance Use/Abuse with Psychological and Physical Intimate Partner Violence: Variations Across Living Situations

Autor: Loretta J. Stalans, Jennifer Ritchie

Publikováno v: Journal of Family Violence. 23:9-24

This study addresses whether the relationship between illicit drug use/abuse measures and intimate partner violence (IPV) varies across socioeconomic status, racial status, and environmental indictors of a drug supportive culture. Data from 19,131 re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35dd813d8fc2c724e20660657a9f5eb3
https://doi.org/10.1007/s10896-007-9125-8

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The material properties of the native porcine mitral valve chordae tendineae: An in vitro investigation

Autor: Ajit P. Yoganathan, Zhaoming He, Jennifer Ritchie, Michael S. Sacks, Jorge H. Jimenez

Publikováno v: Journal of Biomechanics. 39:1129-1135

The material properties of the mitral valve chordae tendineae are important for the understanding of leaflet coaptation configuration and chordal pathology. There is limited information about the mechanical properties of the chordae during physiologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85b74780ea9995cbf85d71bf58e6392
https://doi.org/10.1016/j.jbiomech.2005.01.024

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Transgenic Expression of a Dominant-Negative ASIC3 Subunit Leads to Increased Sensitivity to Mechanical and Inflammatory Stimuli

Autor: Naima Abbadi, Cheryl L. Stucky, Ariel R. Ase, Jennifer Ritchie, Nicole M. Breese, Jeffrey S. Mogil, Philippe Séguéla, Marie-Line Rainville, Marie-France Witty

Publikováno v: The Journal of Neuroscience. 25:9893-9901

Molecular and behavioral evidence suggests that acid-sensing ion channels (ASICs) contribute to pain processing, but an understanding of their precise role remains elusive. Existing ASIC knock-out mouse experiments are complicated by the heteromultim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8263231fefc55bef5b12b2b5b033962d
https://doi.org/10.1523/jneurosci.2019-05.2005

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Mitral Valve Function and Chordal Force Distribution Using a Flexible Annulus Model: An In Vitro Study

Autor: Ajit P. Yoganathan, Jennifer Ritchie, Jorge H. Jimenez, Zhaoming He, Dennis Dam Soerensen

Publikováno v: Annals of Biomedical Engineering. 33:557-566

Since variations in annular motion/shape and papillary muscle displacement have been observed in studies of dilated cardiomyopathy and ischemic mitral regurgitation, the objective of this study was to investigate the effects of annular motion/flexibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5517d65436aadcf13a19e84b9794fc3c
https://doi.org/10.1007/s10439-005-1512-9

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