Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jennifer Raphy"'
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1421-1430
Cyclic sulfamidates function as excellent precursors to a variety of unnatural α,α-disubstituted amino acid derivatives by ring opening with a suitable nucleophile. Addition of various nucleophiles to a sulfamidate derived from 2-methylserine is de
Autor:
Martyn Clive Pritchard, Jennifer Raphy, J.M. Eden, J. Hodgson, P. Boden, David Christopher Horwell, N. Suman-Chauhan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1773-1778
In this paper we describe the transformation of a series of modified dipeptide NK3 receptor selective ligands, previously developed from a hit identified from the screening of a dipeptide chemical library, into non-peptide, nanomolar affinity NK3 rec
Autor:
N. Suman-Chauhan, J.M. Eden, J. Hodgson, Jennifer Raphy, Martyn Clive Pritchard, P. Boden, David Christopher Horwell
Publikováno v:
ChemInform. 26
In this paper we describe the transformation of a series of modified dipeptide NK3 receptor selective ligands, previously developed from a hit identified from the screening of a dipeptide chemical library, into non-peptide, nanomolar affinity NK3 rec
Publikováno v:
ChemInform. 30
Cyclic sulfamidates function as excellent precursors to a variety of unnatural α,α-disubstituted amino acid derivatives by ring opening with a suitable nucleophile. Addition of various nucleophiles to a sulfamidate derived from 2-methylserine is de
Publikováno v:
Expert opinion on investigational drugs. 6(4)
Over the last decade the increasing availability of metabolically- stable non-peptide antagonists targeted at neuropeptide receptors has led directly to a more thorough understanding of the role of neuropeptides in mammalian physiology. By far the ma
Publikováno v:
Immunopharmacology. 33(1-3)
A drug design strategy to non-peptide small molecule antagonists of neuropeptides is described that targets the molecular diversity which exists in the 'privileged' data set of the physico-chemical properties represented by the side-chains of the 20