Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jennifer R. Saam"'
Publikováno v:
Genetics in Medicine. 10:181-186
Purpose: Array comparative genomic hybridization is an emerging test used clinically to identify the etiology of children with developmental delay, yet little data are available regarding how physicians use these results. This pilot study evaluated h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188ee573e9ec6f2a7792a7bb33205088
https://doi.org/10.1097/gim.0b013e3181634eca
https://doi.org/10.1097/gim.0b013e3181634eca
Publikováno v:
Science. 313:1298-1301
The Caenorhabditis elegans anteroposterior axis is established in response to fertilization by sperm. Here we present evidence that RhoA, the guanine nucleotide–exchange factor ECT-2, and the Rho guanosine triphosphatase–activating protein CYK-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4885ac264c446f0c7f3f8d95b27825b4
https://doi.org/10.1126/science.1130291
https://doi.org/10.1126/science.1130291
Publikováno v:
Current Biology. 15(10):894-904
Summary Background: The Aurora kinases control multiple aspects of mitosis, among them centrosome maturation, spindle assembly, chromosome segregation, and cytokinesis. Aurora activity is regulated in part by a subset of Aurora substrates that, once
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aea27a8ecf9eb398401e82c74e61765
Publikováno v:
Current Biology. 14(11):932-941
Background: Epithelial tubes are a key component of organs and are generated from cells with distinct apico-basolateral polarity. Here, we describe a novel function during tubulogenesis for ZEN-4, the Caenorhabditis elegans ortholog of mitotic kinesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6632f974f28273eaea7b45195d2c5a3
Publikováno v:
Experimental Cell Research. 252:416-422
Though DNA methylation is necessary to maintain monoallelic expression of imprinted genes, it is still unclear whether it represents the primary mark. Here we ask whether the imprinting mark is still present in terminally differentiated somatic cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54b53af855d1b70e8f7b56360fb9c33
https://doi.org/10.1006/excr.1999.4627
https://doi.org/10.1006/excr.1999.4627
Publikováno v:
Biology of Reproduction. 54:273-278
Genomic imprinting is an epigenetic phenomenon by which the two parental alleles of a gene are differentially expressed. Although the function of genomic imprinting is not clear, it has been proposed that it evolved in mammals to regulate intrauterin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45542c8f815ab1f21e25dcd84c730bdc
https://doi.org/10.1095/biolreprod54.2.273
https://doi.org/10.1095/biolreprod54.2.273
Autor:
Jennifer R. Saam, Colin L. Stewart, Philip A. Leighton, Shirley M. Tilghman, Robert S. Ingram
Publikováno v:
Genes & Development. 9:2079-2089
The distal end of mouse Chromosome 7 contains four tightly linked genes whose expression is dependent on their parental inheritance. Mash-2 and H19 are expressed exclusively from the maternal chromosome, whereas Insulin-2 (Ins-2) and Insulin-like gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88353cf2fa79374d3c114693bd9e40f
https://doi.org/10.1101/gad.9.17.2079
https://doi.org/10.1101/gad.9.17.2079
Autor:
Jennifer R. Saam, Robert S. Ingram, Kimberly D. Tremblay, Marisa S. Bartolomei, Shirley M. Tilghman
Publikováno v:
Nature Genetics. 9:407-413
Imprinting, the differential expression of the two alleles of a gene based on their parental origin, requires that the alleles be distinguished or marked. A candidate for the differentiating mark is DNA methylation. The maternally expressed H19 gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38bc83a3bd8adee9b3ebd4b3f539961b
https://doi.org/10.1038/ng0495-407
https://doi.org/10.1038/ng0495-407
Publikováno v:
Current biology : CB. 13(22)
Background: The Tousled kinases comprise an evolutionarily conserved family of proteins that have been previously implicated in chromatin remodeling, DNA replication, and DNA repair. Here, we used RNA mediated interference (RNAi) to determine the fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651415559e6707f27ec059cbb1a81d1c
https://pubmed.ncbi.nlm.nih.gov/14614817
https://pubmed.ncbi.nlm.nih.gov/14614817
Autor:
Jennifer R. Saam, Jeffrey I. Gordon, Charles H. Rexer, Melissa H. Wong, Thaddeus S. Stappenbeck
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 97(23)
Defining molecular interactions that occur at the interface between “normal” and “abnormal” cell populations represents an important but often underexplored aspect of the pathogenesis of diseases with focal origins. Here, we illustrate an app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2a15957cb9d547a19220cf5cd7f80a
https://pubmed.ncbi.nlm.nih.gov/11050178
https://pubmed.ncbi.nlm.nih.gov/11050178