Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jennifer R. Pace"'
Autor:
Charles Abakah, Jiayuan Miao, Kirsten Deprey, James D. Baleja, Adam Moyer, Bryan J. Lampkin, Jennifer R. Pace, David Baker, Yu-Shan Lin, Joshua A. Kritzer, Robert A. Cerulli
Publikováno v:
J Am Chem Soc
Peptides constrained by intramolecular cross-links, especially stapled α-helices, have emerged as versatile scaffolds for drug development. However, there are fewer examples of similarly constrained scaffolds for other secondary structures. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b2db5b75ccf8e6895ff17249aed574
https://doi.org/10.1021/jacs.1c04378
https://doi.org/10.1021/jacs.1c04378
Autor:
Joshua A. Kritzer, Jennifer R. Pace, Hawley F. Brown, Robert A. Cerulli, Livia Shehaj, Yang Mei
Publikováno v:
Chembiochem
A growing body of evidence suggests that autophagy inhibition enhances the effectiveness of chemotherapy, especially in difficult-to-treat cancers. Existing autophagy inhibitors are primarily lysosomotropic agents. More specific autophagy inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b068ef6b388b98a96f0180d799b05a7
https://doi.org/10.1002/cbic.202000212
https://doi.org/10.1002/cbic.202000212
Publikováno v:
J Liposome Res
Itraconazole (ITZ) is an FDA-approved antifungal agent that has recently been explored for novel biological properties. In particular, ITZ was identified as a potent inhibitor of the hedgehog (Hh) pathway, a cell signalling pathway that has been link
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a374a83bc3aaa2066ddfe457f79000
https://pubmed.ncbi.nlm.nih.gov/31576768
https://pubmed.ncbi.nlm.nih.gov/31576768
Autor:
Angela M. Zaino, Lianne Q. Chau, Robert J. Wechsler-Reya, M. Kyle Hadden, Kelly A. Teske, Jennifer R Pace, Radha Charan Dash
Publikováno v:
J Med Chem
The FDA-approved antifungal agent, itraconazole (ITZ), has been increasingly studied for its novel biological properties. In particular, ITZ inhibits the hedgehog (Hh) signaling pathway and has the potential to serve as an anti-cancer chemotherapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ecef5820bd681b23a7a0cfb9f6a4ab0
https://pubmed.ncbi.nlm.nih.gov/30896941
https://pubmed.ncbi.nlm.nih.gov/30896941
Autor:
Liangfeng Fu, Gordon W. Gribble, Timothy M. Abbot, Evans O. Onyango, Eliana E. Kim, Jennifer R. Pace
Publikováno v:
Tetrahedron Letters. 57:864-867
Lactols II , obtained by DIBAL reduction of their corresponding lactones I , in equilibrium with their hydroxyaldehyde tautomers III were used in a three-component reductive alkylation with 2-hydroxy-1,4-naphthoquinone to give a series of 3-alkylated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0820bf5278379533a4c0ac94f4b76b6a
https://doi.org/10.1016/j.tetlet.2016.01.036
https://doi.org/10.1016/j.tetlet.2016.01.036
Autor:
Evans O. Onyango, Liangfeng Fu, Jennifer R. Pace, Eliana E. Kim, Gordon W. Gribble, Timothy M. Abbot
Publikováno v:
ChemInform. 47
Lactols II , obtained by DIBAL reduction of their corresponding lactones I , in equilibrium with their hydroxyaldehyde tautomers III were used in a three-component reductive alkylation with 2-hydroxy-1,4-naphthoquinone to give a series of 3-alkylated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c13e3b7a6fbec420d7d4ae5ff2d35e35
https://doi.org/10.1002/chin.201626119
https://doi.org/10.1002/chin.201626119
Autor:
Daniel S. Raccuia, Robert J. Wechsler-Reya, Albert M. DeBerardinis, Silvia K. Tacheva-Grigorova, Vibhavari Sail, Kelly A. Chan, Raymond Tran, M. Kyle Hadden, Jennifer R Pace
Publikováno v:
Journal of medicinal chemistry. 59(8)
Itraconazole (ITZ) is an FDA-approved member of the triazole class of anti-fungal agents. Two recent drug repurposing screens identified ITZ as a promising anti-cancer chemotherapeutic that inhibits both angiogenesis and the hedgehog (Hh) signaling p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a0747045e23927b2dc9a82ed24ba35
https://pubmed.ncbi.nlm.nih.gov/27014922
https://pubmed.ncbi.nlm.nih.gov/27014922
Autor:
M. Kyle Hadden, Jennifer R Pace
Publikováno v:
Cancer Research. 75:3666-3666
The hedgehog (Hh) pathway is a developmental signaling pathway that plays a key role in embryonic development. While the pathway is generally quiescent during adult life, dysregulation of the Hh pathway can lead to cell proliferation and tumor growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebf653f2737613a90a1498a1255bfd26
https://doi.org/10.1158/1538-7445.am2015-3666
https://doi.org/10.1158/1538-7445.am2015-3666