Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Jennifer R. Irons"'
Autor:
Antony P. Jackson, Alexandra McStea, Marisa L. Martin-Fernandez, Andrew J. Thompson, Johanna S. Rees, Christopher J. Tynan, Richard Butler, Lin Wang, Christopher L.-H. Huang, Jennifer R. Irons, Michael Hirsch, Matthew Reed, Samantha C. Salvage
Publikováno v:
The FASEB Journal
Voltage‐gated sodium channels comprise an ion‐selective α‐subunit and one or more associated β‐subunits. The β3‐subunit (encoded by the SCN3B gene) is an important physiological regulator of the heart‐specific sodium channel, Nav1.5. W
Autor:
Christopher L.-H. Huang, Antony P. Jackson, Jonathan R. Silva, Zaki F. Habib, Samantha C. Salvage, Wandi Zhu, Jennifer R. Irons, Soyon S. Hwang
Publikováno v:
The Journal of Biological Chemistry
The auxiliary β3-subunit is an important functional regulator of the cardiac sodium channel Nav1.5, and some β3 mutations predispose individuals to cardiac arrhythmias. The β3-subunit uses its transmembrane α-helix and extracellular domain to bin