Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jennifer R. Gruhn"'
Autor:
Tanja Schlaikjær Hartwig, Louise Ambye, Jennifer R Gruhn, Jesper Friis Petersen, Tine Wrønding, Letizia Amato, Andrew Chi-Ho Chan, Boyang Ji, Maiken Hemme Bro-Jørgensen, Lene Werge, Mette Marie Babiel Schmidt Petersen, Clara Brinkmann, Julie Birch Petersen, Morten Dunø, Iben Bache, Markus J Herrgård, Finn Stener Jørgensen, Eva R Hoffmann, Henriette Svarre Nielsen, Nina la Cour Freiesleben, Finn Stener Jørgensen Jørgensen, Sofie Bliddal, Therese Juhlin Søndergaard, Sisse Rye Ostrowski, Erik Sørensen, Margit Anita Hørup Larsen, Markus J. Herregård, Eva Hoffmann, Jenny Gruhn, Andy Chi Ho Chan, Astrid Marie Kolte, David Westergaard, Unnur þorsteinsdóttir, Kári Stefánsson, Hákon Jónsson, Ólafur þ. Magnússon, Valgerdur Steinthorsdottir, Lone Schmidt, Karsten Kristiansen, Pia Rørbæk Kamstrup, Mette Nyegaard, Maria Christine Krog, Ellen Christine Leth Løkkegaard, Helle Ejdrup Bredkjær, Charlotte Wilken-Jensen
Publikováno v:
Schlaikjær Hartwig, T, Ambye, L, Gruhn, J R, Petersen, J F, Wrønding, T, Amato, L, Chi-Ho Chan, A, Ji, B, Bro-Jørgensen, M H, Werge, L, Petersen, M M B S, Brinkmann, C, Petersen, J B, Dunø, M, Bache, I, Herrgård, M J, Jørgensen, F S, Hoffmann, E R, Nielsen, H S, COPL consortium & Nyegaard, M 2023, ' Cell-free fetal DNA for genetic evaluation in Copenhagen Pregnancy Loss Study (COPL) : a prospective cohort study ', Lancet, vol. 401, no. 10378, pp. 762-771 . https://doi.org/10.1016/S0140-6736(22)02610-1
BACKGROUND: One in four pregnancies end in a pregnancy loss. Although the effect on couples is well documented, evidence-based treatments and prediction models are absent. Fetal aneuploidy is associated with a higher chance of a next successful pregn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a971b9dd4a4677fb8fb9164bebc33e0d
https://doi.org/10.1016/s0140-6736(22)02610-1
https://doi.org/10.1016/s0140-6736(22)02610-1
Autor:
Jennifer R. Gruhn, Eva R. Hoffmann
Publikováno v:
Annual review of genetics. 56
Meiosis, a key process in the creation of haploid gametes, is a complex cellular division incorporating unique timing and intricate chromosome dynamics. Abnormalities in this elaborate dance can lead to the production of aneuploid gametes, i.e., eggs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771310b83fcb7dd789bf39f65a6522f3
https://pubmed.ncbi.nlm.nih.gov/36055648
https://pubmed.ncbi.nlm.nih.gov/36055648
Autor:
Lena Wartosch, Karen Schindler, Melina Schuh, Jennifer R. Gruhn, Eva R. Hoffmann, Rajiv C. McCoy, Jinchuan Xing
Publikováno v:
Prenatal Diagnosis. 41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::321e20b10bafff797abcc71262ec7016
https://doi.org/10.1002/pd.5950
https://doi.org/10.1002/pd.5950
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e85075 (2013)
Meiotic recombination is sexually dimorphic in most mammalian species, including humans, but the basis for the male:female differences remains unclear. In the present study, we used cytological methodology to directly compare recombination levels bet
Externí odkaz:
https://doaj.org/article/16b1d7b22e2f4f6e845c33e7d9ed423c
Autor:
Heather Maylor-Hagen, Eva Hoffmann, Karl W. Broman, Anna Wood, Jennifer R. Gruhn, Patricia A. Hunt, Terry J. Hassold
Publikováno v:
Am J Hum Genet
Failure of homologous chromosomes to recombine is arguably the most important cause of human meiotic nondisjunction, having been linked to numerous autosomal and sex chromosome trisomies of maternal origin. However, almost all information on these "e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908337b8e4348688b7cd82efd699c0ab
https://pubmed.ncbi.nlm.nih.gov/33306948
https://pubmed.ncbi.nlm.nih.gov/33306948
This protocol outlines the generation of metaphase spreads of a single oocyte at either the immature metaphase I (MI) or mature metaphase II (MII) stage. This protocol utilizes formaldehyde fixation and therefore allows for further immunofluorescence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ce8b5fa8d1357521e1d9c3bdda3f6dd
https://doi.org/10.21203/rs.3.pex-968/v1
https://doi.org/10.21203/rs.3.pex-968/v1
The protocol describes the step-by-step procedure of isolating and preparing human oocytes 1) oocytes donated in connection with IVF/ICSI treatment and 2) in vitro matured (IVM) oocytes from small antral follicles donated in connection to fertility p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1aba27dba04a160e67a7eea7f86035f3
https://doi.org/10.21203/rs.3.pex-899/v1
https://doi.org/10.21203/rs.3.pex-899/v1
Autor:
Claus Andersen, Anne Mette Bay Bjørn, Agata P. Zielinska, Robert Blanshard, Lotte Berdiin Colmorn, Deborah M. Taylor, Geraldine M. Hartshorne, Joanna Liss, Louise Newnham, Eva Hoffmann, Marie Louise Grøndahl, Junping Cheng, Dmitry Nikiforov, Ivan Vogel, Jennifer R. Gruhn, Stine Gry Kristensen, Martyn Blayney, Danilo Cimadomo, Andrew Chi-Ho Chan, Vallari Shukla, Rajiv C. McCoy, Melina Schuh, Catello Scarica, Marta Krapchev, Antonio Capalbo, Krzysztof Lukaszuk, Filippo Ubaldi, Erik Ernst, Kay Elder, Laura Rienzi
Publikováno v:
Science
Gruhn, J R, Zielinska, A P, Shukla, V, Blanshard, R, Capalbo, A, Cimadomo, D, Nikiforov, D, Chan, A C H, Newnham, L J, Vogel, I, Scarica, C, Krapchev, M, Taylor, D, Kristensen, S G, Cheng, J, Ernst, E, Bjørn, A M B, Colmorn, L B, Blayney, M, Elder, K, Liss, J, Hartshorne, G, Grøndahl, M L, Rienzi, L, Ubaldi, F, McCoy, R, Lukaszuk, K, Andersen, C Y, Schuh, M & Hoffmann, E R 2019, ' Chromosome errors in human eggs shape natural fertility over reproductive life span ', Science, vol. 365, no. 6460, pp. 1466-1469 . https://doi.org/10.1126/science.aav7321
Gruhn, J R, Zielinska, A P, Shukla, V, Blanshard, R, Capalbo, A, Cimadomo, D, Nikiforov, D, Chan, A C H, Newnham, L J, Vogel, I, Scarica, C, Krapchev, M, Taylor, D, Kristensen, S G, Cheng, J, Ernst, E, Bjørn, A M B, Colmorn, L B, Blayney, M, Elder, K, Liss, J, Hartshorne, G, Grøndahl, M L, Rienzi, L, Ubaldi, F, McCoy, R, Lukaszuk, K, Andersen, C Y, Schuh, M & Hoffmann, E R 2019, ' Chromosome errors in human eggs shape natural fertility over reproductive life span ', Science, vol. 365, no. 6460, pp. 1466-1469 . https://doi.org/10.1126/science.aav7321
Understanding fertility in young and old Fertility in humans follows a U-curve, with low rates in both teenagers and women of advancing maternal age (mid-30s and above). Gruhn et al. found that this distinct shape originates from chromosomal errors i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9297c56d67f4d9699fa8595e6e3463
https://doi.org/10.1097/ogx.0000000000000817
https://doi.org/10.1097/ogx.0000000000000817
Autor:
Rüdiger Moltrecht, K. Bianka Seres, Jennifer R. Gruhn, Heike Eckel, Eva Hoffmann, Martyn Blayney, Kay Elder, Ann-Sophie Frombach, Eirini Bellou, Ninadini Sharma, Melina Schuh, Agata P. Zielinska
Publikováno v:
Zielinska, A P, Bellou, E, Sharma, N, Frombach, A S, Seres, K B, Gruhn, J R, Blayney, M, Eckel, H, Moltrecht, R, Elder, K, Hoffmann, E R & Schuh, M 2019, ' Meiotic Kinetochores Fragment into Multiple Lobes upon Cohesin Loss in Aging Eggs ', Current Biology, vol. 29, no. 22, pp. 3749-3765.e7 . https://doi.org/10.1016/j.cub.2019.09.006
Current Biology
Current Biology
Summary Chromosome segregation errors during female meiosis are a leading cause of pregnancy loss and human infertility. The segregation of chromosomes is driven by interactions between spindle microtubules and kinetochores. Kinetochores in mammalian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9055afc4792c8972c4453a080625341
https://curis.ku.dk/portal/da/publications/meiotic-kinetochores-fragment-into-multiple-lobes-upon-cohesin-loss-in-aging-eggs(db65c38b-cfb3-4c93-933b-bcee29fc0e69).html
https://curis.ku.dk/portal/da/publications/meiotic-kinetochores-fragment-into-multiple-lobes-upon-cohesin-loss-in-aging-eggs(db65c38b-cfb3-4c93-933b-bcee29fc0e69).html
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1818
We describe the collection, culture, and ex vivo, in vitro maturation of germinal vesicle (GV) oocytes obtained from human small antral follicles (hSAFs). hSAFs contain fully grown GV oocytes and have the advantages that they are more numerous than l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3b426ca6d763d82b1df8417a1c800747
https://pubmed.ncbi.nlm.nih.gov/29961251
https://pubmed.ncbi.nlm.nih.gov/29961251