Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jennifer R. Chilenski"'
Autor:
Arlette Solladié-Cavallo, Hugues D'Orchymont, Marin Roje, Philippe Taillasson, Jennifer R. Chilenski, Khalid Azyat, Christopher J. Welch, Claire Marsol
Publikováno v:
European Journal of Organic Chemistry. 2007:826-830
A route toward the synthesis of the erythro isomer of (9-anthryl)(2-piperidyl)methanol is presented as well as resolution and assignment of the structure (through NMR). The use of both the erythro and threo enantiopure isomers of this new amino alcoh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5dea2a634728eb22ed20e5ab4f7e456
https://doi.org/10.1002/ejoc.200600734
https://doi.org/10.1002/ejoc.200600734
Publikováno v:
Synthesis. 2006:3389-3396
A novel sulfoxide-directed borane reduction was shown to give a variety of 2-substituted 1,4-dihydrobenzoxathiins. For all substrates evaluated, the reaction is completely stereospecific. Application of this methodology to the chiral synthesis of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c875279a4faae07ac79cdf9581c191a0
https://doi.org/10.1055/s-2006-950243
https://doi.org/10.1055/s-2006-950243
Publikováno v:
Tetrahedron Letters. 46:5593-5596
Configurational assignment for a wide array of aromatic–heteroaromatic carbinols using NMR method employing α-methoxyphenyl acetic acid (MPA) as a convenient and reliable anisotropic agent is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa1fa86a530140c24e3a52c672badb39
https://doi.org/10.1016/j.tetlet.2005.06.009
https://doi.org/10.1016/j.tetlet.2005.06.009
Autor:
Bindhu V. Karanam, Jennifer R. Chilenski, Vijay G Reddy, Mirlinda Biba, Christopher J. Welch, Stella H. Vincent
Publikováno v:
Drug Metabolism and Disposition. 32:1061-1068
MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)phenyl]methyl]benzamide], a thiazolidinedione (TZD)-containing peroxisome proliferator-activated receptor agonist, is a rapidly interconverting racemate that posses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33857ba5fe6c2f9925766b9c7996f463
https://doi.org/10.1124/dmd.104.000224
https://doi.org/10.1124/dmd.104.000224
Autor:
Paul N. Devine, Michele Kubryk, Richard Desmond, Karl B. Hansen, Edward J. J. Grabowski, David J. Mathre, Varsolona Richard J, Richard M. Heid, Jennifer R. Chilenski
Publikováno v:
Tetrahedron: Asymmetry. 14:3581-3587
(R)-3,5-Bistrifluoromethylphenyl ethanol 2, a key building block in the synthesis of aprepitant, has been synthesized from ketone 5 via catalytic asymmetric transfer hydrogenation using a simplified catalyst generation procedure. The process uses (1S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4787f7de1f480c727da2ee46da2548e7
https://doi.org/10.1016/j.tetasy.2003.08.043
https://doi.org/10.1016/j.tetasy.2003.08.043
Autor:
Robert A. Reamer, Raymond Cvetovich, Jennifer R. Chilenski, Lisa DiMichele, and John Y. L. Chung
Publikováno v:
ChemInform. 38
The Heck coupling of acrylanilides with 4-bromo-2-chloro-3-iodo-pyridine using palladium acetate can produce bis-Heck products or undergo an unusual tandem Heck-lactamization ring formation to generate 5-chloro-1-aryl-1,6-naphthyridin-2(1H)-ones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4d455e11ab7c9ae5433b7ba1d9d7b8
https://doi.org/10.1002/chin.200709152
https://doi.org/10.1002/chin.200709152
Autor:
Jeremy P. Scott, Jennifer R. Chilenski, Andrew D. Gibb, Antony J. Davies, Ulf-H. Dolling, David R. Lieberman, Steven F. Oliver, Karel M. J. Brands, Peter R. Mullens, Sarah E. Brewer
Publikováno v:
Organicbiomolecular chemistry. 4(9)
Intramolecular nitrile oxide–olefin cycloaddition to form hexahydrobenzisoxazole 14, which engenders a phenylsulfonyl, 2,5-difluorophenyl geminally substituted carbon substructure, proceeds with up to 99% ds. A rationalization of the high level of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7dc73f312d8a31e04ebb82f1c23b2da
https://pubmed.ncbi.nlm.nih.gov/16633573
https://pubmed.ncbi.nlm.nih.gov/16633573
Publikováno v:
ChemInform. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c89be4642e97c3cfabbbf6d72611bb5
https://doi.org/10.1002/chin.200418028
https://doi.org/10.1002/chin.200418028
Autor:
Jennifer R. Chilenski, Daniel Zewge, Johnnie L. Leazer, Marjorie S. Waters, Robert A. Reamer, Fengrui Lang, Gary Javadi, Richard D. Tillyer, Matthew M. Bio, Amude M. Kassim, Ralph P. Volante, Anthony O. King, Zhiguo J. Song, Thorsten Rosner, David J. Mathre, David M. Tschaen
An efficient asymmetric synthesis of a selective estrogen receptor modulator (SERM) that has a dihydrobenzoxathiin core structure bearing two stereogenic centers is reported. The stereogenic centers were established by an unprecedented chiral sulfoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc80db2c69738e6ee5dafd2c3226a6f0
https://europepmc.org/articles/PMC395984/
https://europepmc.org/articles/PMC395984/
Nucleophilic displacement at benzhydryl centers: asymmetric synthesis of 1,1-diarylalkyl derivatives
Autor:
Jennifer R. Chilenski, Paul D. O’Shea, David J. Mathre, Cheng-yi Chen, Amélie Roy, Richard D. Tillyer, Francis Gosselin, Yuri Bolshan
Publikováno v:
Organic letters. 6(1)
[reaction: see text] Activation of substituted 1,1-diarylmethanols as their corresponding toluenesulfonates and subsequent displacement with a range of carbon, nitrogen, oxygen, and sulfur nucleophiles proceeds in 81-96% yield. Enantiomerically enric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c3619cbff420946b0c9e98a0cd2a83
https://pubmed.ncbi.nlm.nih.gov/14703363
https://pubmed.ncbi.nlm.nih.gov/14703363