Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jennifer R Linden"'
Autor:
Jennifer R Linden, Claudia Flores, Eric F Schmidt, Francisco A Uzal, Adam O Michel, Marissa Valenzuela, Sebastian Dobrow, Timothy Vartanian
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1008014 (2019)
Clostridium perfringens epsilon toxin (ETX) is responsible for causing the economically devastating disease, enterotoxaemia, in livestock. It is well accepted that ETX causes blood brain barrier (BBB) permeability, however the mechanisms involved in
Externí odkaz:
https://doaj.org/article/6babc98edc8c4f5e95ba4222ccf5b958
Autor:
Kareem Rashid Rumah, Yinghua Ma, Jennifer R Linden, Myat Lin Oo, Josef Anrather, Nicole Schaeren-Wiemers, Miguel A Alonso, Vincent A Fischetti, Mark S McClain, Timothy Vartanian
Publikováno v:
PLoS Pathogens, Vol 11, Iss 5, p e1004896 (2015)
Clostridium perfringens ε-toxin (ETX) is a potent pore-forming toxin responsible for a central nervous system (CNS) disease in ruminant animals with characteristics of blood-brain barrier (BBB) dysfunction and white matter injury. ETX has been propo
Externí odkaz:
https://doaj.org/article/48225ba227d4434f91fe017f57c9a149
Autor:
Yinghua Ma, David Sannino, Jennifer R. Linden, Sylvia Haigh, Baohua Zhao, John B. Grigg, Paul Zumbo, Friederike Dündar, Daniel Butler, Caterina P. Profaci, Kiel Telesford, Paige N. Winokur, Kareem R. Rumah, Susan A. Gauthier, Vincent A. Fischetti, Bruce A. McClane, Francisco A. Uzal, Lily Zexter, Michael Mazzucco, Richard Rudick, David Danko, Evan Balmuth, Nancy Nealon, Jai Perumal, Ulrike Kaunzner, Ilana L. Brito, Zhengming Chen, Jenny Z. Xiang, Doron Betel, Richard Daneman, Gregory F. Sonnenberg, Christopher E. Mason, Timothy Vartanian
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
Multiple sclerosis (MS) is a complex disease of the CNS thought to require an environmental trigger. Gut dysbiosis is common in MS, but specific causative species are unknown. To address this knowledge gap, we used sensitive and quantitative PCR dete
Externí odkaz:
https://doaj.org/article/f0c0efe29a314b36bf138e14c6f076be
Autor:
Samantha V. Shetty, Michael R. Mazzucco, Paige Winokur, Sylvia V. Haigh, Kareem Rashid Rumah, Vincent A. Fischetti, Timothy Vartanian, Jennifer R. Linden
Publikováno v:
Toxins, Vol 15, Iss 7, p 423 (2023)
Clostridium perfringens epsilon toxin (ETX) is the third most lethal bacterial toxin and has been suggested to be an environmental trigger of multiple sclerosis, an immune-mediated disease of the human central nervous system. However, ETX cytotoxicit
Externí odkaz:
https://doaj.org/article/888a14a889c84693a63a1d03514c6b36
Autor:
Drew Adler, Jennifer R. Linden, Samantha V. Shetty, Yinghua Ma, Monika Bokori-Brown, Richard W. Titball, Timothy Vartanian
Publikováno v:
iScience, Vol 15, Iss , Pp 39-54 (2019)
Summary: Clostridium perfringens epsilon toxin (ETX) is hypothesized to mediate blood-brain barrier (BBB) permeability by binding to the myelin and lymphocyte protein (MAL) on the luminal surface of endothelial cells (ECs). However, the kinetics of t
Externí odkaz:
https://doaj.org/article/d559d06e4735453092ec67a885d9b724
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-24 (2022)
Background Multiple sclerosis (MS) is a complex, heterogenous disease characterized by inflammation, demyelination, and blood–brain barrier (BBB) permeability. Currently, active disease is determined by physician confirmed relapse or detection of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a52e719c77cd8e57822c5e946e602a3
https://doi.org/10.1186/s12987-021-00299-4
https://doi.org/10.1186/s12987-021-00299-4
Autor:
Jennifer R. Linden, Kiel Telesford, Samantha Shetty, Paige Winokour, Sylvia Haigh, Ellen Cahir-McFarland, Giovanna Antognetti, Abhishek Datta, Tao Wang, Werner Meier, Timothy Vartanian
Publikováno v:
Antibodies, Vol 7, Iss 4, p 37 (2018)
The pore-forming epsilon toxin (ETX) produced by Clostridium perfringens is among the most lethal bacterial toxins known. Sensitive antibody-based reagents are needed to detect toxin, distinguish mechanisms of cell death, and prevent ETX toxicity. Us
Externí odkaz:
https://doaj.org/article/3d10856f453c49769bff5bff93b3c8ab
Autor:
Timothy Vartanian, Monika Bokori-Brown, Samantha V. Shetty, Drew Adler, Yinghua Ma, Richard W. Titball, Jennifer R. Linden
Publikováno v:
iScience
iScience, Vol 15, Iss, Pp 39-54 (2019)
iScience, Vol 15, Iss, Pp 39-54 (2019)
Summary Clostridium perfringens epsilon toxin (ETX) is hypothesized to mediate blood-brain barrier (BBB) permeability by binding to the myelin and lymphocyte protein (MAL) on the luminal surface of endothelial cells (ECs). However, the kinetics of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a07967af85ff2afb78815c49397a96d
https://doi.org/10.1016/j.isci.2019.04.016
https://doi.org/10.1016/j.isci.2019.04.016
Publikováno v:
Bio Protoc
In order for the brain to function properly, a carefully orchestrated homeostasis must be maintained. To help regulate this delicate balance, the brain has developed a highly selective blood-brain barrier (BBB). Under normal conditions, the BBB exclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f384698b26ff24d37d511b00b2d7c515
https://europepmc.org/articles/PMC7842667/
https://europepmc.org/articles/PMC7842667/
Autor:
Libra B. Williams, Juan Sepulveda, Anthony Vartanian, Sam Bogdanov, Patricia Miraflor, Samantha B. Regan, Steffi Gaehde, Jennifer R. Linden, Noah Rubin, Sarah Shetty, Jake Moreh, Abigail Lustig, Zuha Anwar, Sylvia Haigh
Publikováno v:
Anaerobe. 54:124-127
Food samples (n = 216) from New York city were tested for the presence of C. perfringens via PCR for specific toxin genes. Thirty-four (16%) samples were positive for C. perfringens. Of these 34, 31 (91.2%) were type A or E, one (2.9%) was type B, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191c00bc0fce4e555a65e1c872691cc9
https://doi.org/10.1016/j.anaerobe.2018.08.008
https://doi.org/10.1016/j.anaerobe.2018.08.008