Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Jennifer R Cochran"'
Autor:
Shankar Subramaniam, Metin Akay, Mark A. Anastasio, Vasudev Bailey, David Boas, Paolo Bonato, Ashutosh Chilkoti, Jennifer R. Cochran, Vicki Colvin, Tejal A. Desai, James S. Duncan, Frederick H. Epstein, Stephanie Fraley, Cecilia Giachelli, K. Jane Grande-Allen, Jordan Green, X. Edward Guo, Isaac B. Hilton, Jay D. Humphrey, Chris R Johnson, George Karniadakis, Michael R. King, Robert F. Kirsch, Sanjay Kumar, Cato T. Laurencin, Song Li, Richard L. Lieber, Nigel Lovell, Prashant Mali, Susan S. Margulies, David F. Meaney, Brenda Ogle, Bernhard Palsson, Nicholas A. Peppas, Eric J. Perreault, Rick Rabbitt, Lori A. Setton, Lonnie D. Shea, Sanjeev G. Shroff, Kirk Shung, Andreas S. Tolias, Marjolein C.H. van der Meulen, Shyni Varghese, Gordana Vunjak-Novakovic, John A. White, Raimond Winslow, Jianyi Zhang, Kun Zhang, Charles Zukoski, Michael I. Miller
Publikováno v:
IEEE Open Journal of Engineering in Medicine and Biology, Vol 5, Pp 1-13 (2024)
Over the past two decades Biomedical Engineering has emerged as a major discipline that bridges societal needs of human health care with the development of novel technologies. Every medical institution is now equipped at varying degrees of sophistica
Externí odkaz:
https://doaj.org/article/99aa19c8944b4368939a87375caa3abd
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60498 (2013)
BackgroundCystine-knot miniproteins, also known as knottins, have shown great potential as molecular scaffolds for the development of targeted therapeutics and diagnostic agents. For this purpose, previous protein engineering efforts have focused on
Externí odkaz:
https://doaj.org/article/ca2be32f20cc460f80181c6f688ba77b
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16112 (2011)
BackgroundThe Ecballium elaterium trypsin inhibitor (EETI-II), a 28-amino acid member of the knottin family of peptides, contains three interwoven disulfide bonds that form multiple solvent-exposed loops. Previously, the trypsin binding loop of EETI-
Externí odkaz:
https://doaj.org/article/4e230f00ace64e6c86bd000d5b1c272c
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 9, p e1000499 (2009)
Cystine-knot miniproteins (knottins) are promising molecular scaffolds for protein engineering applications. Members of the knottin family have multiple loops capable of displaying conformationally constrained polypeptides for molecular recognition.
Externí odkaz:
https://doaj.org/article/15e0dbd616bb496181bb0972eb0c18a1
Autor:
Anindya Roy, Lei Shi, Ashley Chang, Xianchi Dong, Andres Fernandez, John C. Kraft, Jing Li, Viet Q. Le, Rebecca Viazzo Winegar, Gerald Maxwell Cherf, Dean Slocum, P. Daniel Poulson, Garrett E. Casper, Mary L. Vallecillo-Zúniga, Jonard Corpuz Valdoz, Marcos C. Miranda, Hua Bai, Yakov Kipnis, Audrey Olshefsky, Tanu Priya, Lauren Carter, Rashmi Ravichandran, Cameron M. Chow, Max R. Johnson, Suna Cheng, McKaela Smith, Catherine Overed-Sayer, Donna K. Finch, David Lowe, Asim K. Bera, Gustavo Matute-Bello, Timothy P. Birkland, Frank DiMaio, Ganesh Raghu, Jennifer R. Cochran, Lance J. Stewart, Melody G. Campbell, Pam M. Van Ry, Timothy Springer, David Baker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The RGD (Arg-Gly-Asp)-binding integrins αvβ6 and αvβ8 are clinically validated cancer and fibrosis targets of considerable therapeutic importance. Compounds that can discriminate between homologous αvβ6 and αvβ8 and other RGD integri
Externí odkaz:
https://doaj.org/article/e3c311aafe5446188603fdc35eee2511
Autor:
Brianna J. McIntosh, Griffin G. Hartmann, Sean A. Yamada‐Hunter, Phillip Liu, Camille F. Williams, Julien Sage, Jennifer R. Cochran
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 6, Pp n/a-n/a (2023)
Abstract The cytokine interleukin (IL)‐11 has been shown to play a role in promoting fibrosis and cancer, including lung adenocarcinoma, garnering interest as an attractive target for therapeutic intervention. We used combinatorial methods to engin
Externí odkaz:
https://doaj.org/article/e074518fcf654bf4858ad1a87a84c9f0
Autor:
Leiping Zeng, Yanxia Liu, Xammy Huu Nguyenla, Timothy R. Abbott, Mengting Han, Yanyu Zhu, Augustine Chemparathy, Xueqiu Lin, Xinyi Chen, Haifeng Wang, Draven A. Rane, Jordan M. Spatz, Saket Jain, Arjun Rustagi, Benjamin Pinsky, Adrianna E. Zepeda, Anastasia P. Kadina, John A. Walker, Kevin Holden, Nigel Temperton, Jennifer R. Cochran, Annelise E. Barron, Michael D. Connolly, Catherine A. Blish, David B. Lewis, Sarah A. Stanley, Marie F. La Russa, Lei S. Qi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
A major challenge in coronavirus vaccination and treatment is to counteract rapid viral evolution and mutations. Here the authors show that CRISPR-Cas13d can be used as a broad-spectrum antiviral to inhibit human coronaviruses, including new SARS-CoV
Externí odkaz:
https://doaj.org/article/b19524c1f85b4105af7741efdca8ff41
Autor:
Oliver F. Wirz, Katharina Röltgen, Bryan A. Stevens, Suchitra Pandey, Malaya K. Sahoo, Lorna Tolentino, Michelle Verghese, Khoa Nguyen, Molly Hunter, Theo Thomas Snow, Abhay Raj Singh, Catherine A. Blish, Jennifer R. Cochran, James L. Zehnder, Kari C. Nadeau, Benjamin A. Pinsky, Tho D. Pham, Scott D. Boyd
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundTransfusion of COVID-19 convalescent plasma (CCP) containing high titers of anti-SARS-CoV-2 antibodies serves as therapy for COVID-19 patients. Transfusions early during disease course was found to be beneficial. Lessons from the SARS-CoV-2
Externí odkaz:
https://doaj.org/article/b756a711f6284a47a38414781cb759aa
Autor:
Kartik Bhamidipati, John L. Silberstein, Yashaar Chaichian, Matthew C. Baker, Tobias V. Lanz, Amin Zia, Yusuf S. Rasheed, Jennifer R. Cochran, William H. Robinson
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by B cell dysregulation and breaks in tolerance that lead to the production of pathogenic autoantibodies. We performed single-cell RNA sequencing of B cells from healthy donors
Externí odkaz:
https://doaj.org/article/4b456a0624c4482a801fd0c416c5218c
Autor:
Caitlyn L. Miller, Idit Sagiv-Barfi, Patrick Neuhöfer, Debra K. Czerwinski, Carolyn R. Bertozzi, Jennifer R. Cochran, Ronald Levy
Publikováno v:
J Immunol
Spontaneous tumors that arise in genetically engineered mice recapitulate the natural tumor microenvironment and tumor-immune coevolution observed in human cancers, providing a more physiologically relevant preclinical model relative to implanted tum