Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Jennifer Q Kwong"'
Autor:
Chiemela Ohanele, Jessica N. Peoples, Anja Karlstaedt, Joshua T. Geiger, Ashley D. Gayle, Nasab Ghazal, Fateemaa Sohani, Milton E. Brown, Michael E. Davis, George A. Porter, Victor Faundez, Jennifer Q. Kwong
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract The developing mammalian heart undergoes an important metabolic shift from glycolysis towards mitochondrial oxidation that is critical to support the increasing energetic demands of the maturing heart. Here, we describe a new mechanistic lin
Externí odkaz:
https://doaj.org/article/303b6bcf721b461cb58adc8d83829c32
Autor:
Yohei Matsunaga, Hiroshi Qadota, Nasab Ghazal, Leila Lesanpezeshki, Till Dorendorf, Jasmine C. Moody, Arnaud Ahier, Courtney J. Matheny, Siva A. Vanapalli, Steven Zuryn, Olga Mayans, Jennifer Q. Kwong, Guy M. Benian
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract UNC-89 is a giant sarcomeric M-line protein required for sarcomere organization and optimal muscle function. UNC-89 contains two protein kinase domains, PK1 and PK2, separated by an elastic region. Here we show that PK2 is a canonical kinase
Externí odkaz:
https://doaj.org/article/bba44bd80c7247d28d8e36412ab42597
Autor:
Davy Vanhoutte, Tobias G Schips, Jennifer Q Kwong, Jennifer Davis, Andoria Tjondrokoesoemo, Matthew J Brody, Michelle A Sargent, Onur Kanisicak, Hong Yi, Quan Q Gao, Joseph E Rabinowitz, Talila Volk, Elizabeth M McNally, Jeffery D Molkentin
Publikováno v:
eLife, Vol 5 (2016)
Skeletal muscle is highly sensitive to mutations in genes that participate in membrane stability and cellular attachment, which often leads to muscular dystrophy. Here we show that Thrombospondin-4 (Thbs4) regulates skeletal muscle integrity and its
Externí odkaz:
https://doaj.org/article/211d0d632f9543a2ab9249ddaf6593b3
Autor:
Jason Karch, Jennifer Q Kwong, Adam R Burr, Michelle A Sargent, John W Elrod, Pablo M Peixoto, Sonia Martinez-Caballero, Hanna Osinska, Emily H-Y Cheng, Jeffrey Robbins, Kathleen W Kinnally, Jeffery D Molkentin
Publikováno v:
eLife, Vol 2 (2013)
A critical event in ischemia-based cell death is the opening of the mitochondrial permeability transition pore (MPTP). However, the molecular identity of the components of the MPTP remains unknown. Here, we determined that the Bcl-2 family members Ba
Externí odkaz:
https://doaj.org/article/05dd5d4356784fc28183de961bc98086
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82053 (2013)
Myofiber wasting in muscular dystrophy has largely been ascribed to necrotic cell death, despite reports identifying apoptotic markers in dystrophic muscle. Here we set out to identify the contribution of canonical apoptotic pathways to skeletal musc
Externí odkaz:
https://doaj.org/article/68cc6454da7d49518970c71b1d1886b4
Autor:
Chiemela Ohanele, Jessica N. Peoples, Anja Karlstaedt, Joshua T. Geiger, Ashley D. Gayle, Nasab Ghazal, Fateemaa Sohani, Milton E. Brown, Michael E. Davis, George A. Porter, Victor Faundez, Jennifer Q. Kwong
Publikováno v:
bioRxiv
SUMMARYThe developing mammalian heart undergoes an important metabolic shift from glycolysis toward mitochondrial oxidation, such that oxidative phosphorylation defects may present with cardiac abnormalities. Here, we describe a new mechanistic link
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a2cbc42720c6b9b22abd05bb2deb36
https://doi.org/10.1101/2023.05.22.541833
https://doi.org/10.1101/2023.05.22.541833
Publikováno v:
Am J Physiol Cell Physiol
Limb-girdle muscular dystrophy R12 (LGMD-R12) is caused by recessive mutations in the Anoctamin-5 gene ( ANO5, TMEM16E). Although ANO5 myopathy is not X-chromosome linked, we performed a meta-analysis of the research literature and found that three-q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d623ffd77c7db7262e1191944de9870
https://doi.org/10.1152/ajpcell.00350.2021
https://doi.org/10.1152/ajpcell.00350.2021
Autor:
Shigeo Ohta, Hideaki Oda, Giovanni Manfredi, Jennifer Q. Kwong, Kazutoshi Nakano, Takashi Kanamori, Kumi Yamagata, Yujiro Shidara
Supplementary Figure 1 from Positive Contribution of Pathogenic Mutations in the Mitochondrial Genome to the Promotion of Cancer by Prevention from Apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e301e0e0397b47faec4933326591907
https://doi.org/10.1158/0008-5472.22364387
https://doi.org/10.1158/0008-5472.22364387
Autor:
Shigeo Ohta, Hideaki Oda, Giovanni Manfredi, Jennifer Q. Kwong, Kazutoshi Nakano, Takashi Kanamori, Kumi Yamagata, Yujiro Shidara
The role of mitochondrial dysfunction in cancer has been a subject of great interest and much ongoing investigation. Although most cancer cells harbor somatic mutations in mitochondrial DNA (mtDNA), the question of whether such mutations contribute t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a70c6e1882c7ca42cfe5e640accdb68
https://doi.org/10.1158/0008-5472.c.6494165
https://doi.org/10.1158/0008-5472.c.6494165
Autor:
Jennifer Q. Kwong, Xiyuan Lu, Robert N. Correll, Jennifer A. Schwanekamp, Ronald J. Vagnozzi, Michelle A. Sargent, Allen J. York, Jianyi Zhang, Donald M. Bers, Jeffery D. Molkentin
Publikováno v:
Cell Reports, Vol 12, Iss 1, Pp 15-22 (2015)
In the heart, augmented Ca2+ fluxing drives contractility and ATP generation through mitochondrial Ca2+ loading. Pathologic mitochondrial Ca2+ overload with ischemic injury triggers mitochondrial permeability transition pore (MPTP) opening and cardio
Externí odkaz:
https://doaj.org/article/24c55190390241b081190447c3450bdc