Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jennifer Pardieck"'
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-19 (2022)
Abstract Background Spinal interneurons (INs) relay sensory and motor control information between the brain and body. When this relay circuitry is disrupted from injury or disease, it is devastating to patients due to the lack of native recovery in c
Externí odkaz:
https://doaj.org/article/d3c7a934243841d4a06adca78ace0ace
Publikováno v:
Stem Cells Dev
The ventral spinal population of V0 interneurons (INs) contribute to the coordinated movements directed by spinal central pattern generators (CPGs), including respiratory circuits and left-right alternation. One challenge in studying V0 INs has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73d068b50921885477eafda85e9c4c3
https://doi.org/10.1089/scd.2021.0003
https://doi.org/10.1089/scd.2021.0003
Publikováno v:
Stem cell researchtherapy. 13(1)
Spinal interneurons (INs) relay sensory and motor control information between the brain and body. When this relay circuitry is disrupted from injury or disease, it is devastating to patients due to the lack of native recovery in central nervous syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8be37f92f8ac3850e53fdd6c3feebda6
https://pubmed.ncbi.nlm.nih.gov/35346349
https://pubmed.ncbi.nlm.nih.gov/35346349
Autor:
Shelly E. Sakiyama-Elbert, Molly S. Shoichet, Lindsay Crawford, Laura Smith, Peter Kenny, Russell E. Thompson, Jennifer Pardieck
Publikováno v:
Biomaterials. 162:208-223
One reason for the lack of regeneration, and poor clinical outcomes, following central nervous system (CNS) injury is the formation of a glial scar that inhibits new axon growth. In addition to forming the glial scar, astrocytes have been shown to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7293e95d4e82c0d34c7886a559b00946
https://doi.org/10.1016/j.biomaterials.2018.02.013
https://doi.org/10.1016/j.biomaterials.2018.02.013
Autor:
Bing He, Alba Cico, Shannon McKinney-Freeman, Daniel J. McGoldrick, Angelica C. Saulsberry, David Finkelstein, Miguel Ganuza, Kai Tan, Joseph Moen, Trent Hall, Per Holmfeldt, Jennifer Pardieck, Ludovic Gaut, Himangi Marathe, Guolian Kang
Publikováno v:
Journal of Experimental Medicine. 213:433-449
Understanding the molecular regulation of hematopoietic stem and progenitor cell (HSPC) engraftment is paramount to improving transplant outcomes. To discover novel regulators of HSPC repopulation, we transplanted >1,300 mice with shRNA-transduced HS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d7ae6943a4caf0bce72860eacc9af61
https://doi.org/10.1084/jem.20150806
https://doi.org/10.1084/jem.20150806
Publikováno v:
Acta Biomaterialia. 28:23-32
Regeneration of lost synaptic connections following spinal cord injury (SCI) is limited by local ischemia, cell death, and an excitotoxic environment, which leads to the development of an inhibitory glial scar surrounding a cystic cavity. While a var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30b917faa0c36080bf7dc8fc92933ee
https://doi.org/10.1016/j.actbio.2015.09.018
https://doi.org/10.1016/j.actbio.2015.09.018
Recent developments in genome engineering methods have advanced our knowledge of central nervous system (CNS) function in both normal health and following disease or injury. This review discusses current literature using gene editing tools in CNS dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8d63648b488d8660a926f78a2d28ad
https://europepmc.org/articles/PMC6082714/
https://europepmc.org/articles/PMC6082714/
Autor:
Angela R. Schubert, Zoltan Varga, Arie Krumholz, Eric J. Hsu, Jennifer Pardieck, Jianmin Cui, Mark A. Zaydman, Jonathan R. Silva, Wandi Zhu
Background— Dysregulation of voltage-gated cardiac Na + channels (Na V 1.5) by inherited mutations, disease-linked remodeling, and drugs causes arrhythmias. The molecular mechanisms whereby the Na V 1.5 voltage-sensing domains (VSDs) are perturbed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26ea0daddf5430dd3bcd1e6b2b6350d
https://europepmc.org/articles/PMC4618166/
https://europepmc.org/articles/PMC4618166/
Autor:
David Finkelstein, Jennifer Pardieck, Anjelica C. Saulsberry, Shannon McKinney-Freeman, Per Holmfeldt, John T. Gray, Satish K. Nandakumar, Derek A. Persons
Publikováno v:
Blood. 122(17)
Hematopoietic stem cells are both necessary and sufficient to sustain the complete blood system of vertebrates. Here we show that Nfix, a member of the nuclear factor I (Nfi) family of transcription factors, is highly expressed by hematopoietic stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee6134fe138d05b53d0a6fafd258cb9
https://pubmed.ncbi.nlm.nih.gov/24041575
https://pubmed.ncbi.nlm.nih.gov/24041575
Autor:
Angelica C. Saulsberry, David Finkelstein, Ludovic Gaut, Shannon McKinney-Freeman, Miguel Ganuza, Joseph Moen, Daniel J. McGoldrick, Alba Cico, Jennifer Pardieck, Trent Hall, Guolian Kang, Bing He, Per Holmfeldt, Kai Tan, Himangi Marathe
Publikováno v:
The Journal of Experimental Medicine
Holmfeldt et al. perform a transplant-based screen to identify regulators of HSPC engraftment and report that Foxa3 is critical for optimal HSC function after transplant.
Understanding the molecular regulation of hematopoietic stem and progenito
Understanding the molecular regulation of hematopoietic stem and progenito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f5a4a66ccd970ad4dfcc7da086ca87
https://doi.org/10.1084/jem.2015080609232016c
https://doi.org/10.1084/jem.2015080609232016c