Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jennifer P. Kitzmann"'
Autor:
Efstathios S. Avgoustiniatos, Kate R. Mueller, William E. Scott III, Jennifer P. Kitzmann, Thomas M. Suszynski, Brian E. Perrault, Eric J. Falde, A. N. Balamurugan, Bernhard J. Hering, Charles W. Putnam, Klearchos K. Papas
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
IntroductionConventional culture conditions, such as in T-flasks, require that oxygen diffuse through the medium to reach the islets; in turn, islet surface area density is limited by oxygen availability. To culture a typical clinical islet preparati
Externí odkaz:
https://doaj.org/article/6e961f6e73b748fc88ec72a36aad0d63
Autor:
Bradley P. Weegman, Venkata Sunil Kumar Sajja, Thomas M. Suszynski, Michael D. Rizzari, William E. Scott III, Jennifer P. Kitzmann, Kate R. Mueller, Thomas R. Hanley, David J. Kennedy, Paul W. Todd, Appakalai N. Balamurugan, Bernhard J. Hering, Klearchos K. Papas
Publikováno v:
Journal of Diabetes Research, Vol 2016 (2016)
Islet transplantation (ITx) is an emerging and promising therapy for patients with uncontrolled type 1 diabetes. The islet isolation and purification processes require exposure to extended cold ischemia, warm-enzymatic digestion, mechanical agitation
Externí odkaz:
https://doaj.org/article/aa99a7761a9f4a6d84331188f4ff9b73
Autor:
Klearchos K Papas, Melena D Bellin, David E R Sutherland, Thomas M Suszynski, Jennifer P Kitzmann, Efstathios S Avgoustiniatos, Angelika C Gruessner, Kathryn R Mueller, Gregory J Beilman, Appakalai N Balamurugan, Gopalakrishnan Loganathan, Clark K Colton, Maria Koulmanda, Gordon C Weir, Josh J Wilhelm, Dajun Qian, Joyce C Niland, Bernhard J Hering
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134428 (2015)
BackgroundReliable in vitro islet quality assessment assays that can be performed routinely, prospectively, and are able to predict clinical transplant outcomes are needed. In this paper we present data on the utility of an assay based on cellular ox
Externí odkaz:
https://doaj.org/article/3b1106a0d9a04b4484572e0579606e02
Autor:
Klearchos K. Papas, Sahar Usmani-Brown, Wenyu Gou, Charlie Strange, Kevan C. Herold, Craig E. Crosson, Colleen A. Cloud, Katherine A. Morgan, Jennifer P. Kitzmann, Betsy Shuford, David B. Adams, Louis M. Luttrell, Tara Duke, Hongjun Wang, Paul J. Nietert, Pamela Clark, Jingjing Wang, Stefanie Owzarski, Aaron P. Lesher
Publikováno v:
Cell Transplantation
Cell Transplantation, Vol 28 (2019)
Cell Transplantation, Vol 28 (2019)
Stresses encountered during human islet isolation lead to unavoidable β-cell death after transplantation. This reduces the chance of insulin independence in chronic pancreatitis patients undergoing total pancreatectomy and islet autotransplantation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca4c2bea671c2f4028f31261f184c7d
https://pubmed.ncbi.nlm.nih.gov/31885286
https://pubmed.ncbi.nlm.nih.gov/31885286
Autor:
Ronald M. Lynch, Peter Strop, Jennifer P. Kitzmann, Fiona M. McCarthy, Vasudeo Badarinarayana, Craig Weber, Sean W. Limesand, Catherine G. Min, J. Brett Stanton, Angelika C. Gruessner, Amy C. Kelly, Kate E. Smith, Klearchos K. Papas, Leah V. Steyn
Publikováno v:
Transplantation. 101:2705-2712
BACKGROUND Encapsulation devices have the potential to enable cell-based insulin replacement therapies (such as human islet or stem cell-derived β cell transplantation) without immunosuppression. However, reasonably sized encapsulation devices promo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d8aab6a93a5e3435893e558feb5db2
https://doi.org/10.1097/tp.0000000000001714
https://doi.org/10.1097/tp.0000000000001714
Autor:
Jennifer P. Kitzmann, Michael Garwood, Bradley P. Weegman, Samuel A. Einstein, Klearchos K. Papas
Publikováno v:
Biotechnology and Bioengineering. 114:1118-1121
Transplantation of macroencapsulated tissue-engineered grafts (TEGs) is being investigated as a treatment for type 1 diabetes, but there is a critical need to measure TEG viability both in vitro and in vivo. Oxygen deficiency is the most critical iss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80e48fc776ebf6a291295f043671fdfa
https://doi.org/10.1002/bit.26227
https://doi.org/10.1002/bit.26227
Autor:
Appakalai N. Balamurugan, David J. Kennedy, Kate R. Mueller, William E. Scott, Jennifer P. Kitzmann, Thomas M. Suszynski, Klearchos K. Papas, Venkata Sunil Kumar Sajja, Paul Todd, Thomas R. Hanley, Michael Rizzari, Bernhard J. Hering, Bradley P. Weegman
Publikováno v:
Journal of Diabetes Research, Vol 2016 (2016)
Journal of Diabetes Research
Journal of Diabetes Research
Islet transplantation (ITx) is an emerging and promising therapy for patients with uncontrolled type 1 diabetes. The islet isolation and purification processes require exposure to extended cold ischemia, warm-enzymatic digestion, mechanical agitation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69915fc1173db13ee87d3e18eb9e159b
https://doi.org/10.1155/2016/6162970
https://doi.org/10.1155/2016/6162970
Autor:
Doug O’Gorman, Klearchos K. Papas, Sharleen Imes, Tatsuya Kin, Jennifer P. Kitzmann, A. M. J. Shapiro, Angelika C. Gruessner, Peter A. Senior, Rainer W.G. Gruessner
Publikováno v:
Transplantation Proceedings. 46:1985-1988
Background Human islet allotransplantation for the treatment of type 1 diabetes is in phase III clinical trials in the U.S. and is the standard of care in several other countries. Current islet product release criteria include viability based on cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9a4e36a2fac1c9fe50c2482042d3d7
https://doi.org/10.1016/j.transproceed.2014.06.001
https://doi.org/10.1016/j.transproceed.2014.06.001
Autor:
Melanie L. Graham, Rebecca L. Pongratz, Gary W. Cline, Bradley P. Weegman, Henk-Jan Schuurman, Jennifer P. Kitzmann, Rebecca L. Hooper, Appakalai N. Balamurugan, Klearchos K. Papas, Kate R. Mueller, Michael J. Taylor
Publikováno v:
Xenotransplantation. 20:75-81
Porcine islet xenotransplantation is considered a potential cell-based therapy for type 1 diabetes. It is currently being evaluated in diabetic nonhuman primates (NHP) to assess safety and efficacy of the islet product. However, due to a variety of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e200b8265cc3dbab9510c9010096397
https://doi.org/10.1111/xen.12022
https://doi.org/10.1111/xen.12022
Autor:
Kate R. Mueller, Klearchos K. Papas, Lee Law, Avik Shome, Henk Jan Schuurman, Jennifer P. Kitzmann, Robert B. Elliott, Marija Muzina
Publikováno v:
Xenotransplantation. 19:333-336
Clinical islet transplantation using human pancreasdonors in patients with type 1 diabetes mellitus isan established cellular therapy, primarily, for thosepatients who suffer from severe hypoglycemicunawareness [1]. However, the low availability ofp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5ff4bcc80058aa2ad76943ba34448e7
https://doi.org/10.1111/xen.12005
https://doi.org/10.1111/xen.12005