Výsledky vyhledávání - "Jennifer P. DeAngelis"

The role of P4-P3’ residues flanking Arg336 in facilitating activated protein C-catalyzed cleavage and inactivation of factor VIIIa

Autor: Jennifer P. DeAngelis, Fatbardha Varfaj, Philip J. Fay, Hironao Wakabayashi

Publikováno v: Thrombosis Research. 128:470-476

Introduction Activated protein C (APC) inactivates factor VIIIa (FVIIIa) through cleavages at Arg336 in the A1 subunit and Arg562 in the A2 subunit. Proteolysis at Arg336 occurs 25-fold faster than at Arg562. Replacing residues flanking Arg336 en blo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32f5fb01c52f55b4ec0300d160ea5fb
https://doi.org/10.1016/j.thromres.2011.03.007

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Sequences flanking Arg336 in factor VIIIa modulate factor Xa-catalyzed cleavage rates at this site and cofactor function

Autor: Jennifer P. DeAngelis, Hironao Wakabayashi, Philip J. Fay

Publikováno v: The Journal of biological chemistry. 287(19)

Factor (F)VIII can be activated to FVIIIa by FXa following cleavages at Arg(372), Arg(740), and Arg(1689). FXa also cleaves FVIII/FVIIIa at Arg(336) and Arg(562) resulting in inactivation of the cofactor. These inactivating cleavages occur on a slowe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ca1d5a07c7fe00b35654835b788154
https://pubmed.ncbi.nlm.nih.gov/22411993

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Generation of enhanced stability factor VIII variants by replacement of charged residues at the A2 domain interface

Autor: Fatbardha Varfaj, Jennifer P. DeAngelis, Hironao Wakabayashi, Philip J. Fay

Publikováno v: Blood. 112(7)

Factor VIII consists of a heavy chain (A1A2B domains) and light chain (A3C1C2 domains), whereas the contiguous A1A2 domains are separate subunits in the cofactor, factor VIIIa. The intrinsic instability of the cofactor results from weak affinity inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9099a91e8d334978bf4f3a9815fd762
https://pubmed.ncbi.nlm.nih.gov/18650448

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Luciferase from the Italian firefly Luciola italica: molecular cloning and expression

Autor: Elisa Michelini, Jennifer P. DeAngelis, Bruce R. Branchini, Aldo Roda, Tara L. Southworth

The cDNA encoding the luciferase from the Italian firefly Luciola italica was cloned using reverse transcriptase-PCR and a gene-specific primer set based on the DNA sequence of Luciola mingrelica. The cDNA sequence of L. italica luciferase was determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff20b5f57e813aa08cc1ec8221e6bdc2
http://hdl.handle.net/11585/38604

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P2 and P2′ Residues Are Important for the Efficient Proteolysis of Factor VIIIa at Arg336 Catalyzed by Activated Protein C

Autor: Jennifer P. DeAngelis, Philip J. Fay, Fatbardha Varfaj, Hironao Wakabayashi

Publikováno v: Blood. 110:2689-2689

Activated Protein C (APC) is an anticoagulant serine protease that proteolytically inactivates the coagulation cofactors, factors (F) Va and VIIIa. FVIIIa is a non-covalent heterotrimer consisting of A1, A2 and A3-C1-C2 subunits. APC-catalyzed inacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26c87520fec3f568747b5e965182d7bf
https://doi.org/10.1182/blood.v110.11.2689.2689

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