Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Jennifer P, Morton"'
Autor:
Paul K. Drain, Xin Niu, Adrienne E. Shapiro, Zanele P. Magcaba, Zinhle Ngcobo, M William Ngwane, Katherine K. Thomas, Ronit R. Dalmat, Jennifer F. Morton, Elvira Budiawan, Abraham Pinter, Jason Cantera, Caitlin Anderson, Rose Buchmann, Doug Wilson, Ben Grant
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105353- (2024)
Summary: Background: Development of a non-sputum test using readily-obtainable biospecimens remains a global priority for tuberculosis (TB) control. We quantified lipoarabinomannan (LAM) concentrations, a pathogen biomarker for Mycobacterium tubercul
Externí odkaz:
https://doaj.org/article/215bee391d9e4b2994b4c41d141ec419
Autor:
Meirion Raymant, Yuliana Astuti, Laura Alvaro-Espinosa, Daniel Green, Valeria Quaranta, Gaia Bellomo, Mark Glenn, Vatshala Chandran-Gorner, Daniel H. Palmer, Christopher Halloran, Paula Ghaneh, Neil C. Henderson, Jennifer P. Morton, Manuel Valiente, Ainhoa Mielgo, Michael C. Schmid
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease for which better therapies are urgently needed. Fibroblasts and macrophages are heterogeneous cell populations able to enhance metastasis, but the role of a macrophage-fi
Externí odkaz:
https://doaj.org/article/eea8d7fa84a347b4b29c4bbb66667b6a
Autor:
Mathias Tesson, Jennifer P. Morton
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 7 (2024)
Externí odkaz:
https://doaj.org/article/ecacb9b1cfeb43a58029acee1d9bf7c3
Autor:
Arafath K. Najumudeen, Sigrid K. Fey, Laura M. Millett, Catriona A. Ford, Kathryn Gilroy, Nuray Gunduz, Rachel A. Ridgway, Eve Anderson, Douglas Strathdee, William Clark, Colin Nixon, Jennifer P. Morton, Andrew D. Campbell, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Oncogenic KRAS mutations are well-described functionally and are known to drive tumorigenesis. Recent reports describe a significant prevalence of KRAS allelic imbalances or gene dosage changes in human cancers, including loss of the wild-ty
Externí odkaz:
https://doaj.org/article/cc435f850ded4ca6b07a54a34129b55d
Autor:
Elzette Rousseau, Kathleen J. Sikkema, Robin F. Julies, Katelyn Mazer, Gabrielle O'Malley, Renee Heffron, Jennifer F. Morton, Rachel Johnson, Connie Celum, Jared M. Baeten, Linda‐Gail Bekker
Publikováno v:
Journal of the International AIDS Society, Vol 27, Iss 5, Pp n/a-n/a (2024)
Abstract Introduction Adolescent girls and young women (AGYW), a priority population for HIV prevention in Africa, show high interest but difficulty in sustained effective use of pre‐exposure prophylaxis (PrEP). With ongoing PrEP scale‐up focused
Externí odkaz:
https://doaj.org/article/d6c8d2888cf44c3b811023ee3b03de8f
Autor:
Declan Whyte, George Skalka, Peter Walsh, Ania Wilczynska, Nikki R. Paul, Claire Mitchell, Colin Nixon, William Clarke, Martin Bushell, Jennifer P. Morton, Daniel J. Murphy, Nathiya Muthalagu
Publikováno v:
Molecular Oncology, Vol 17, Iss 7, Pp 1212-1227 (2023)
The AMP‐activated protein kinase (AMPK)‐related kinase NUAK1 (NUAK family SNF1‐like kinase 1) has emerged as a potential vulnerability in MYC‐dependent cancer but the biological roles of NUAK1 in different settings are poorly characterised, a
Externí odkaz:
https://doaj.org/article/6896303684144ae5bf0d4de609aa31de
Autor:
Mathias Tesson, Katrina Stevenson, Saadia A. Karim, Colin Nixon, Anthony J. Chalmers, Owen J. Sansom, Eric O'Neill, Keaton Jones, Jennifer P. Morton
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/811eecd6813e422088dd8c4cda49dc78
Autor:
Connie Celum, Dominika Seidman, Danielle Travill, Christine Dehlendorf, Sanele Gumede, Kidist Zewdie, Whitney Wilson, Jennifer F. Morton, Jared M. Baeten, Deborah Donnell, Sinead Delany‐Moretlwe
Publikováno v:
Journal of the International AIDS Society, Vol 26, Iss 8, Pp n/a-n/a (2023)
Abstract Introduction African adolescent girls and young women (AGYW) have high rates of HIV acquisition and are a priority population for HIV pre‐exposure prophylaxis (PrEP). PrEP implementation has been limited by AGYW's low perceived HIV risk an
Externí odkaz:
https://doaj.org/article/b30a3ac1663c46ddb82daade59522c5c
Autor:
Jennifer P Morton, Matthew Wilson, Hannah Buckley, Alwin G Schuller, Richard Goodwin, Kate Williamson, Frances M Richards, Duncan I Jodrell, Saadia A Karim, Simon J Dovedi, Jim Eyles, Vincenzo Graziano, Andreas Dannhorn, Heather Hulme, Sheng Y Lee, Brajesh P Kaistha, Sabita Islam, James E D Thaventhiran, Rebecca Brais
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)
Background The prognosis for patients with pancreatic ductal adenocarcinoma (PDAC) remains extremely poor. It has been suggested that the adenosine pathway contributes to the ability of PDAC to evade the immune system and hence, its resistance to imm
Externí odkaz:
https://doaj.org/article/f9d832bad08344709ee59ce32bb6e960
Autor:
Eva C. Freckmann, Emma Sandilands, Erin Cumming, Matthew Neilson, Alvaro Román-Fernández, Konstantina Nikolatou, Marisa Nacke, Tamsin R. M. Lannagan, Ann Hedley, David Strachan, Mark Salji, Jennifer P. Morton, Lynn McGarry, Hing Y. Leung, Owen J. Sansom, Crispin J. Miller, David M. Bryant
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
There are currently a lack of tools to detect heterogeneity in 3D cultures. Here the authors report Traject3d as a framework to identify heterogeneous states in 3D culture and to understand how these give rise to distinct phenotypes using label-free
Externí odkaz:
https://doaj.org/article/d1ea5c3909d0472cb9c9c41a696d4ec5