Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jennifer Oki"'
Autor:
Alice Mac Kain, Ghizlane Maarifi, Sophie-Marie Aicher, Nathalie Arhel, Artem Baidaliuk, Sandie Munier, Flora Donati, Thomas Vallet, Quang Dinh Tran, Alexandra Hardy, Maxime Chazal, Françoise Porrot, Molly OhAinle, Jared Carlson-Stevermer, Jennifer Oki, Kevin Holden, Gert Zimmer, Etienne Simon-Lorière, Timothée Bruel, Olivier Schwartz, Sylvie van der Werf, Nolwenn Jouvenet, Sébastien Nisole, Marco Vignuzzi, Ferdinand Roesch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Here, Mac Kain and Maarifi et al. perform a functional CRISPR/Cas9 screen to identify SARS-CoV-2 restriction factors in A549 cells. They identify DAXX, a scaffold protein of nuclear bodies with diverse functions, that has anti-viral activity post SAR
Externí odkaz:
https://doaj.org/article/2979f6b8098645b5aa9271d3426c5eed
Autor:
Rebecca C. Lamothe, Meghan D. Storlie, Diego A. Espinosa, Rachel Rudlaff, Patrick Browne, Jason Liu, Andres Rivas, Audra Devoto, Jennifer Oki, Ashcon Khoubyari, Daniela S. Aliaga Goltsman, Jyun-Liang Lin, Cristina N. Butterfield, Christopher T. Brown, Brian C. Thomas, Gregory J. Cost
Publikováno v:
The CRISPR Journal.
Autor:
David, Conant, Tim, Hsiau, Nicholas, Rossi, Jennifer, Oki, Travis, Maures, Kelsey, Waite, Joyce, Yang, Sahil, Joshi, Reed, Kelso, Kevin, Holden, Brittany L, Enzmann, Rich, Stoner
Publikováno v:
The CRISPR Journal. 5:123-130
Efficient and precise genome editing requires a fast, quantitative, and inexpensive assay to assess genotype following editing. Here, we present ICE (Inference of CRISPR Edits), which enables robust analysis of CRISPR edits using Sanger data. ICE pro
Autor:
Irene P. Chen, James E. Longbotham, Sarah McMahon, Rahul K. Suryawanshi, Mir M. Khalid, Taha Y. Taha, Takako Tabata, Jennifer M. Hayashi, Frank W. Soveg, Jared Carlson-Stevermer, Meghna Gupta, Meng Yao Zhang, Victor L. Lam, Yang Li, Zanlin Yu, Erron W. Titus, Amy Diallo, Jennifer Oki, Kevin Holden, Nevan Krogan, Danica Galonić Fujimori, Melanie Ott
Publikováno v:
Cell reports, vol 40, iss 3
bioRxiv
bioRxiv
Inhibitors of bromodomain and extraterminal domain (BET) proteins are possible anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prophylactics as they downregulate angiotensin-converting enzyme 2 (ACE2). Here we show that BET proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5372b20c38023d14b59bc671f5a2a48
https://escholarship.org/uc/item/2pf842c8
https://escholarship.org/uc/item/2pf842c8
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2
Autor:
Quang Dinh Tran, Xiaoyan Guo, Jonathan S. Weissman, Jared Carlson-Stevermer, Marco Vignuzzi, Jennifer Oki, Shion A. Lim, Merissa Chen, Sarah J. Rockwood, Kevin Holden, James K. Nuñez, Avi J. Samelson, Travis J. Maures, Veronica V. Rezelj, James A. Wells, Gokul N. Ramadoss, Bruce R. Conklin, Martin Kampmann, Na Liu, Irene Lui, Alice Mac Kain, Ruilin Tian
Publikováno v:
Nature Cell Biology
Nature Cell Biology, 2022, 24 (1), pp.24-34. ⟨10.1038/s41556-021-00821-8⟩
Nature cell biology, vol 24, iss 1
bioRxiv
article-version (status) pre
article-version (number) 1
Nature Cell Biology, 2022, 24 (1), pp.24-34. ⟨10.1038/s41556-021-00821-8⟩
Nature cell biology, vol 24, iss 1
bioRxiv
article-version (status) pre
article-version (number) 1
SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to its cell-surface receptor ACE2. We conducted a targeted CRISPRi screen to uncover druggable pathways controlling Spike protein binding to human cells. We fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9836aaa4388fd836bf4f32463f43d9e4
https://hal-pasteur.archives-ouvertes.fr/pasteur-04133563/file/samelson_kampmann_nihms-1759623.pdf
https://hal-pasteur.archives-ouvertes.fr/pasteur-04133563/file/samelson_kampmann_nihms-1759623.pdf
Autor:
Alice Mac Kain, Françoise Porrot, Ferdinand Roesch, Molly OhAinle, Etienne Simon-Loriere, Nolwenn Jouvenet, Artem Baidaliuk, Kevin Holden, Nathalie J. Arhel, Alexandra Hardy, Quang Dinh Tran, Olivier Schwartz, Marco Vignuzzi, Sébastien Nisole, Thomas Vallet, Sophie-Marie Aicher, Jennifer Oki, Timothée Bruel, Maxime Chazal, Jared Carlson-Stevermer, Ghizlane Maarifi
Interferon restricts SARS-CoV-2 replication in cell culture, but only a handful of Interferon Stimulated Genes with antiviral activity against SARS-CoV-2 have been identified. Here, we describe a functional CRISPR/Cas9 screen aiming at identifying SA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9a764841cdcc7b04d4a208e2e31d90
https://hal.archives-ouvertes.fr/hal-03448425
https://hal.archives-ouvertes.fr/hal-03448425
Autor:
Anita Sil, Jennifer M. Hayashi, Katherine A. Travisano, Jared Carlson-Stevermer, Kevin Holden, Jennifer Oki, Keith Walcott, Nevan J. Krogan, Lauren Rodriguez, Ruofan Wang, James Zengel, Camille R. Simoneau, Jessie Kulsuptrakul, Jan E. Carette, Andreas S. Puschnik, Parinaz Fozouni, Mehdi Bouhaddou, Melanie Ott, Christopher M. Richards, Bastian Joehnk
Publikováno v:
Cell
Cell, vol 184, iss 1
Cell, vol 184, iss 1
The Coronaviridae are a family of viruses that cause disease in humans ranging from mild respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host factors common to multiple coronaviruses could facilitate the devel
Autor:
Andreas S. Puschnik, Jessie Kulsuptrakul, Camille R. Simoneau, Katherine A. Travisano, Kevin Holden, Jared Carlson-Stevermer, Melanie Ott, Mehdi Bouhaddou, Jennifer M. Hayashi, Jennifer Oki, Ruofan Wang, Nevan J. Krogan
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
TheCoronaviridaeare a family of viruses that causes disease in humans ranging from mild respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host factors that are common to multiple coronaviruses could facilitate t
Autor:
Stacie A. Chvatal, Anthony M. Nicolini, Kevin Holden, Jared Carlson-Stevermer, Jennifer Oki, Jesus A. Silvas, Christopher F. Basler, Caroline G. Williams, Alexander S. Jureka
Publikováno v:
Cell Reports
bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv
article-version (status) pre
article-version (number) 1
Coronaviruses rely on host membranes for entry, establishment of replication centers, and egress. Compounds targeting cellular membrane biology and lipid biosynthetic pathways have previously shown promise as antivirals and are actively being pursued
Autor:
Peter Lotfy, Nicholas J. Brideau, Jennifer Oki, Patrick D. Hsu, Maxim N. Shokhirev, Silvana Konermann
Publikováno v:
Cell, vol 173, iss 3
Summary Class 2 CRISPR-Cas systems endow microbes with diverse mechanisms for adaptive immunity. Here, we analyzed prokaryotic genome and metagenome sequences to identify an uncharacterized family of RNA-guided, RNA-targeting CRISPR systems that we c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ca7e6be2ac79241b13648bff0de07f
https://escholarship.org/uc/item/2jb871f7
https://escholarship.org/uc/item/2jb871f7