Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jennifer N. Pearson"'
Autor:
Ruth E. Fulton, Jennifer N. Pearson-Smith, Christopher Q. Huynh, Timothy Fabisiak, Li-Ping Liang, Stefanos Aivazidis, Brigit A. High, Georgia Buscaglia, Timothy Corrigan, Robert Valdez, Takahiko Shimizu, Manisha N. Patel
Publikováno v:
Neurobiology of Disease, Vol 158, Iss , Pp 105470- (2021)
Mitochondrial superoxide (O2−) production is implicated in aging, neurodegenerative disease, and most recently epilepsy. Yet the specific contribution of neuronal O2− to these phenomena is unclear. Here, we selectively deleted superoxide dismutas
Externí odkaz:
https://doaj.org/article/05ca107846c64e9d90c8cc9f4faa05a3
Publikováno v:
Redox Biology, Vol 20, Iss , Pp 275-284 (2019)
Persistent inhibition of acetylcholinesterase resulting from exposure to nerve agents such as soman, is associated with prolonged seizure activity known as status epilepticus (SE). Without medical countermeasures, exposure to soman and resultant SE l
Externí odkaz:
https://doaj.org/article/c9de8c7f1bce405a8b22200c81180b2d
Publikováno v:
Neurobiology of Disease, Vol 133, Iss , Pp - (2020)
The use of chemical warfare agents is an ongoing, significant threat to both civilians and military personnel worldwide. Nerve agents are by far the most formidable toxicants in terms of their lethality and toxicity. Nerve agents initiate neurotoxici
Externí odkaz:
https://doaj.org/article/403e162c3dc446f4ab8432af65ee368e
Publikováno v:
Neurobiology of Disease, Vol 98, Iss , Pp 88-99 (2017)
Cognitive dysfunction is a major comorbidity of the epilepsies; however, treatments targeting seizure-associated cognitive dysfunction, particularly deficits in learning and memory are not available. Isoketals and neuroketals, collectively known as g
Externí odkaz:
https://doaj.org/article/7b7809f333204bfe9153813bebc72318
Autor:
Jennifer N. Pearson, Shane Rowley, Li-Ping Liang, Andrew M. White, Brian J. Day, Manisha Patel
Publikováno v:
Neurobiology of Disease, Vol 82, Iss , Pp 289-297 (2015)
Cognitive dysfunction is an important comorbidity of temporal lobe epilepsy (TLE). However, no targeted therapies are available and the mechanisms underlying cognitive impairment, specifically deficits in learning and memory associated with TLE remai
Externí odkaz:
https://doaj.org/article/8aa29d3d42d347fd8c98ce88ce74a2e9
Autor:
Jennifer N. Pearson-Smith, Ruth Fulton, Christopher Q. Huynh, Anna G. Figueroa, Gia B. Huynh, Li-Ping Liang, Lindsey B. Gano, Cole R. Michel, Nichole Reisdorph, Richard Reisdorph, Kristofer S. Fritz, Eric Verdin, Manisha Patel
Publikováno v:
The Journal of Neuroscience. 43:1845-1857
Mitochondrial dysfunction is an early event in the pathogenesis of neurologic disorders and aging. Sirtuin 3 (SIRT3) regulates mitochondrial function in response to the cellular environment through the reversible deacetylation of proteins involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f7bfe46380102298f80c41166006ad3
https://doi.org/10.1523/jneurosci.1259-22.2023
https://doi.org/10.1523/jneurosci.1259-22.2023
Autor:
Manisha Patel, Brian J. Day, Erica L. Bradshaw-Pierce, Jennifer N. Pearson-Smith, Li-Ping Liang, Ruth Fulton
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 377:1-10
Oxidative stress plays a crucial role in the pathogenesis of Parkinson disease (PD), and one strategy for neuroprotective therapy for PD is to scavenge reactive species using a catalytic antioxidant. Previous studies in our laboratory revealed that p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e098fcd7c1fa2d40f418821950fc2907
https://doi.org/10.1124/jpet.120.000229
https://doi.org/10.1124/jpet.120.000229
Autor:
Brigit A. High, Ruth Fulton, Timothy Fabisiak, Georgia Buscaglia, Jennifer N. Pearson-Smith, Stefanos Aivazidis, Christopher Q Huynh, Li-Ping Liang, Takahiko Shimizu, Timothy Corrigan, Manisha Patel, Robert Valdez
Publikováno v:
Neurobiology of Disease, Vol 158, Iss, Pp 105470-(2021)
Neurobiol Dis
Neurobiol Dis
Mitochondrial superoxide (O(2)(.−)) production is implicated in aging, neurodegenerative disease, and most recently epilepsy. Yet the specific contribution of neuronal O(2)(.−) to these phenomena is unclear. Here, we selectively deleted superoxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f1e82bc3487221770cd1a77caa7760
http://www.sciencedirect.com/science/article/pii/S0969996121002199
http://www.sciencedirect.com/science/article/pii/S0969996121002199
Autor:
Robert Valdez, Manisha Patel, Christopher Q. Huynh, Li-Ping Liang, Stefanos Aivazidis, Timothy Corrigan, Jennifer N. Pearson-Smith, Takahiko Shimizu, Timothy J. Fabisiak, Ruth E. Fulton, Brigit A. High, Etienne Danis, Georgia Buscaglia
Publikováno v:
SSRN Electronic Journal.
Mitochondrial superoxide (O2.-) production is implicated in aging, neurodegenerative disease, and most recently epilepsy. Yet the specific contribution of neuronal O2.- to these phenomenon is unclear. Here, we selectively deleted superoxide dismutase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53da04ae6e345d71e638717f1ca5807c
https://doi.org/10.2139/ssrn.3784893
https://doi.org/10.2139/ssrn.3784893
Autor:
Manisha Patel, Jie Huang, Li-Ping Liang, Brian J. Day, Jennifer N. Pearson-Smith, Ruth Fulton
Publikováno v:
Toxicology and Applied Pharmacology. 326:34-42
Reactive oxygen species are a well-defined therapeutic target for Parkinson’s disease (PD) and pharmacological agents that catalytically scavenge reactive species are promising neuroprotective strategies for treatment. Metalloporphyrins are synthet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91ca3ad58b5053ec1c704015ebabee1
https://doi.org/10.1016/j.taap.2017.04.004
https://doi.org/10.1016/j.taap.2017.04.004