Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jennifer N. O'Reilly"'
Autor:
Jennifer N. O’Reilly, Dmitri Svistounov, Svetlana N. Zykova, David G. Le Couteur, Samantha M. Solon-Biet, Alessandra Warren, Michel Lebel, Rafa de Cabo, J. William O. Ballard, Victoria C. Cogger, Richard G. Melvin, Aisling C. McMahon
Publikováno v:
The Journals of Gerontology: Series A. 69:1076-1086
Werner syndrome is a progeric syndrome characterized by premature atherosclerosis, diabetes, cancer, and death in humans. The knockout mouse model created by deletion of the RecQ helicase domain of the mouse Wrn homologue gene (Wrn(∆hel/∆hel)) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab958482623b905acd5f79215fa6bc6
https://doi.org/10.1093/gerona/glt169
https://doi.org/10.1093/gerona/glt169
Publikováno v:
Pathology. 42:255-258
Aims: Fenestrations are pores in the liver sinusoidal endothelial cell that facilitate the transfer of substrates between blood and hepatocytes. The aim of this study was to determine the effect of nutritional state on the morphology of fenestrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab6db25c68bd5250c9e47e0d411662d
https://doi.org/10.3109/00313021003636469
https://doi.org/10.3109/00313021003636469
Publikováno v:
AGE. 32:69-77
Apolipoprotein E (apoE) is associated with aging and some age-related diseases. The majority of apoE is produced by hepatocytes for the receptor-mediated uptake of lipoproteins. Here, the effects of age on the hepatic expression and distribution of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11197629780f18abf82894dbde52cf4
https://doi.org/10.1007/s11357-009-9115-2
https://doi.org/10.1007/s11357-009-9115-2
Autor:
Peter Zahradka, Carla G. Taylor, Laurent Massip, Eric Thorin, Victoria C. Cogger, Avril Hatherell, Jennifer N. O’Reilly, Chantal Garand, Leslee Tworek, Eric Paquet, Michel Lebel, David G. Le Couteur
Publikováno v:
The FASEB Journal. 24:158-172
Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-like DNA helicase. Mice lacking the helicase domain of the WRN homologue exhibit many phenotypic features of WS, including a prooxidant status and a shorter mean life sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f47f96f65e72df2989e252e04e28638
https://doi.org/10.1096/fj.09-137133
https://doi.org/10.1096/fj.09-137133
Autor:
Jennifer N. O’Reilly, Victoria C. Cogger, Sarah N. Hilmer, David G. Le Couteur, Rajkumar Cheluvappa, Sun Young Kwun
Publikováno v:
International Journal of Experimental Pathology. 89:410-418
The liver sinusoidal endothelial cell (LSEC) is damaged by many toxins, including oxidants and bacterial toxins. Any effect on LSECs of the Pseudomonas aeruginosa virulence factor, pyocyanin, may be relevant for systemic pseudomonal infections and li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08c1733f0d733c01c3105415cf3ef7fe
https://doi.org/10.1111/j.1365-2613.2008.00602.x
https://doi.org/10.1111/j.1365-2613.2008.00602.x
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 32:492-498
Post-mortem studies of the human brain indicate that certain GABA(A) receptor subtypes may be differentially altered in schizophrenia. Increased binding to the total population of GABA(A) receptors using [3H]muscimol is observed in the post-mortem sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf666e79a1c6728fad1030b91fda041
https://doi.org/10.1016/j.pnpbp.2007.10.003
https://doi.org/10.1016/j.pnpbp.2007.10.003
Autor:
Alessandra Warren, Stephen J. Simpson, Robin Fraser, Andrew J. Holmes, Bui Thanh Tung, Victoria C. Cogger, David Raubenheimer, Samantha M. Solon-Biet, Dmitri Svistounov, Alistair M. Senior, Mashani Mohamad, Jennifer N. O’Reilly, David G. Le Couteur, Aisling Clare McMahon
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
et al.
Fenestrations are pores within the liver sinusoidal endothelial cells (LSECs) that line the sinusoids of the highly vascularized liver. Fenestrations facilitate the transfer of substrates between blood and hepatocytes. With pseudocapillar
Fenestrations are pores within the liver sinusoidal endothelial cells (LSECs) that line the sinusoids of the highly vascularized liver. Fenestrations facilitate the transfer of substrates between blood and hepatocytes. With pseudocapillar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0db1c002d83efbf57e7b13931075f7
http://hdl.handle.net/10261/163261
http://hdl.handle.net/10261/163261
Autor:
Sun Young Kwun, Michael Muller, Rajkumar Cheluvappa, Hamish A. Jamieson, Sarah N. Hilmer, Jennifer N. O’Reilly, David G. Le Couteur, Victoria C. Cogger
Publikováno v:
Experimental Gerontology. 42:1012-1019
In old age, the liver contains less ATP and hypoxia-responsive genes are upregulated. Age-related changes in hepatic perfusion and the liver sinusoidal endothelial cell (LSEC) could contribute to this altered hepatic oxygen-dependent metabolism by ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2576fc0c8d9483afdf1ed7b5b3489c
https://doi.org/10.1016/j.exger.2007.06.001
https://doi.org/10.1016/j.exger.2007.06.001
Publikováno v:
Schizophrenia Research. 90:76-80
Changes in GABA(A) receptors are observed in schizophrenia, with benzodiazepine-sensitive GABA(A) receptor subtypes being affected differently to other subtypes. However, long-term antipsychotic drug use in schizophrenia may underlie these changes. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87084f808aca5c8aad94a05d1835cf68
https://doi.org/10.1016/j.schres.2006.11.009
https://doi.org/10.1016/j.schres.2006.11.009
Publikováno v:
Journal of visualized experiments : JoVE. (98)
Liver sinusoidal endothelial cells are the gateway to the liver, their transcellular fenestrations allow the unimpeded transfer of small and dissolved substances from the blood into the liver parenchyma for metabolism and processing. Fenestrations ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ddbadb3a214cf20808165781234a0da
https://pubmed.ncbi.nlm.nih.gov/25993325
https://pubmed.ncbi.nlm.nih.gov/25993325