Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jennifer N. Murdoch"'
Autor:
Anila Iqbal, Marta Baldrighi, Jennifer N. Murdoch, Angeleen Fleming, Christopher J. Wilkinson
Publikováno v:
Biology Open, Vol 9, Iss 10 (2020)
Protein aggregates are the pathogenic hallmarks of many different neurodegenerative diseases and include the accumulation of α-synuclein, the main component of Lewy bodies found in Parkinson's disease. Aggresomes are closely-related, cellular accumu
Externí odkaz:
https://doaj.org/article/b19edf1be5544779ba5a6025beeaa66a
Autor:
Jennifer N. Murdoch, Christine Damrau, Anju Paudyal, Debora Bogani, Sara Wells, Nicholas D. E. Greene, Philip Stanier, Andrew J. Copp
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 10, Pp 1153-1163 (2014)
Neural tube defects (NTDs) are among the commonest and most severe forms of developmental defect, characterized by disruption of the early embryonic events of central nervous system formation. NTDs have long been known to exhibit a strong genetic dep
Externí odkaz:
https://doaj.org/article/97de87b50a4e4ca0a710889558ea52d5
Autor:
Anila Iqbal, Marta Baldrighi, Angeleen Fleming, Jennifer N. Murdoch, Christopher J. Wilkinson
Publikováno v:
Biology Open, Vol 9, Iss 10 (2020)
Biology Open
article-version (VoR) Version of Record
Biology Open
article-version (VoR) Version of Record
Protein aggregates are the pathogenic hallmarks of many different neurodegenerative diseases and include the accumulation of α-synuclein, the main component of Lewy bodies found in Parkinson's disease. Aggresomes are closely-related, cellular accumu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a33de6a809ffaa4c744ec75999c72ab
Autor:
Jennifer N. Murdoch, Andrew J. Copp
Publikováno v:
Birth Defects Research Part A: Clinical and Molecular Teratology. 88:633-652
The Hedgehog signaling pathway is essential for many aspects of normal embryonic development, including formation and patterning of the neural tube. Absence of the sonic hedgehog (shh) ligand is associated with the midline defect holoprosencephaly, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2c26f5b5ad65613c8a1f45a654b6e4
https://doi.org/10.1002/bdra.20686
https://doi.org/10.1002/bdra.20686
Autor:
Charbel Darido, Jennifer N. Murdoch, Vishwas Parekh, Sebastian Dworkin, Stephen B. Ting, Gerhard Rank, Thomas Weber, Nidal Boulos, Tony Papenfuss, Jacinta Caddy, Stephen M. Jane, Alana Auden, Seema Srivastava, John M. Cunningham, Jian Zuo, Tomasz Wilanowski, Quan Zhao, Patrick O. Humbert
Publikováno v:
Developmental Cell. 19:138-147
SummaryThe mammalian PCP pathway regulates diverse developmental processes requiring coordinated cellular movement, including neural tube closure and cochlear stereociliary orientation. Here, we show that epidermal wound repair is regulated by PCP si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39bcf8326b8c30cc1272e7889dbc2988
https://doi.org/10.1016/j.devcel.2010.06.008
https://doi.org/10.1016/j.devcel.2010.06.008
Autor:
Stuart Townsend, Lee Niswander, Caroline J. Formstone, Jennifer N. Murdoch, Laura L. Yates, Charlotte H. Dean, Carsten Schnatwinkel, Andy Greenfield, Debora Bogani
Publikováno v:
Human Molecular Genetics
The lungs are generated by branching morphogenesis as a result of reciprocal signalling interactions between the epithelium and mesenchyme during development. Mutations that disrupt formation of either the correct number or shape of epithelial branch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0efcfb93cdf23cccb7456ae278ed6f61
http://europepmc.org/articles/PMC2865378
http://europepmc.org/articles/PMC2865378
Publikováno v:
Circulation Research. 96:292-299
Loop-tail ( Lp ) mice develop double outlet right ventricle and aortic arch defects, and the defects are caused by mutations in the Vangl2 gene. Vangl2 mRNA is found in the outflow tract myocardium, including the myocardializing cells that migrate in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef9bf56757d88f62d4f602410e5c0b8
https://doi.org/10.1161/01.res.0000154912.08695.88
https://doi.org/10.1161/01.res.0000154912.08695.88
Publikováno v:
Nature Reviews Genetics. 4:784-793
More than 80 mutant mouse genes disrupt neurulation and allow an in-depth analysis of the underlying developmental mechanisms. Although many of the genetic mutants have been studied in only rudimentary detail, several molecular pathways can already b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a126a64d0b4369b5ddc186fb5f62f8f7
https://doi.org/10.1038/nrg1181
https://doi.org/10.1038/nrg1181
Autor:
Ruth M. Arkell, Patrick M. Nolan, Andrew J. Copp, Philip Stanier, Steve D.M. Brown, Ian C. Gray, Karen P. Steel, Deborah J. Henderson, Jennifer N. Murdoch, Nigel K. Spurr, Bruce Cattanach, Vicky Tsipouri, Elizabeth M. C. Fisher, Elizabeth Quint, John A. Curtin
Publikováno v:
Current Biology. 13(13):1129-1133
We identified two novel mouse mutants with abnormal head-shaking behavior and neural tube defects during the course of independent ENU mutagenesis experiments. The heterozygous and homozygous mutants exhibit defects in the orientation of sensory hair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad768889430a65c3e4481ea049aa2443
Autor:
Jennifer N. Murdoch, Sara Wells, Christine Damrau, Anju Paudyal, Debora Bogani, Andrew J. Copp, Nicholas D. E. Greene, Philip Stanier
Publikováno v:
Disease Models & Mechanisms.
Neural tube defects (NTDs) are among the commonest and most severe forms of developmental defect, characterized by disruption of the early embryonic events of central nervous system formation. NTDs have long been known to exhibit a strong genetic dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::139d3fdd02974f714b92db45bb21efc1
https://doi.org/10.1242/dmm.016758
https://doi.org/10.1242/dmm.016758