Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Jennifer N. Bourne"'
Autor:
Kristen M. Harris, Dusten D. Hubbard, Masaaki Kuwajima, Wickliffe C. Abraham, Jennifer N. Bourne, Jared B. Bowden, Andrea Haessly, John M. Mendenhall, Patrick H. Parker, Bitao Shi, Josef Spacek
Publikováno v:
Neuroscience
Microtubules deliver essential resources to and from synapses. Three-dimensional reconstructions in rat hippocampus reveal a sampling bias regarding spine density that needs to be controlled for dendrite caliber and resource delivery based on microtu
Autor:
Luipa Khandker, Angelina V. Evangelou, Marie L. Mather, Teresa L. Wood, Lauren E. McLane, Jennifer N. Bourne, Divyangi Kantak, Wendy B. Macklin, Marisa A. Jeffries
Publikováno v:
J Neurosci
In demyelinating diseases, such as multiple sclerosis, primary loss of myelin and subsequent neuronal degeneration throughout the CNS impair patient functionality. While the importance of mechanistic target of rapamycin (mTOR) signaling during develo
Autor:
Heather L Smith, Jennifer N Bourne, Guan Cao, Michael A Chirillo, Linnaea E Ostroff, Deborah J Watson, Kristen M Harris
Publikováno v:
eLife, Vol 5 (2016)
Mitochondria support synaptic transmission through production of ATP, sequestration of calcium, synthesis of glutamate, and other vital functions. Surprisingly, less than 50% of hippocampal CA1 presynaptic boutons contain mitochondria, raising the qu
Externí odkaz:
https://doaj.org/article/7ef402e4ae9f4b719bb405eeb76fd52d
Autor:
Thomas M Bartol Jr, Cailey Bromer, Justin Kinney, Michael A Chirillo, Jennifer N Bourne, Kristen M Harris, Terrence J Sejnowski
Publikováno v:
eLife, Vol 4 (2015)
Information in a computer is quantified by the number of bits that can be stored and recovered. An important question about the brain is how much information can be stored at a synapse through synaptic plasticity, which depends on the history of prob
Externí odkaz:
https://doaj.org/article/d02e7856deed47e9841ef92d0d2805f8
Autor:
Jennifer N. Bourne, Samantha L Schwartz, Olga Prikhodko, Alexandra Lucas, Kevin C. Crosby, Harrison J. Ramsay, Christina S. Winborn, Brooke L. Sinnen, Hannah S. Actor-Engel, Mark L. Dell'Acqua, Katherine R. Smith, Matthew J. Kennedy
Publikováno v:
eNeuro
Secreted amyloid-β (Aβ) peptide forms neurotoxic oligomeric assemblies thought to cause synaptic deficits associated with Alzheimer's disease (AD). Soluble Aβ oligomers (Aβo) directly bind to neurons with high affinity and block plasticity mechan
Publikováno v:
Proc Natl Acad Sci U S A
Long-term potentiation (LTP) is a cellular mechanism of learning and memory that results in a sustained increase in the probability of vesicular release of neurotransmitter. However, previous work in hippocampal area CA1 of the adult rat revealed tha
Autor:
Jennifer N. Bourne, Kristen M. Harris, Mikayla S. Waters, Michael A. Chirillo, Laurence F. Lindsey
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Synapse clustering facilitates circuit integration, learning, and memory. Long-term potentiation (LTP) of mature neurons produces synapse enlargement balanced by fewer spines, raising the question of how clusters form despite this homeostatic regulat
Publikováno v:
Glia. 67:650-667
Demyelination occurs following many neurological insults, most notably in multiple sclerosis (MS). Therapeutics that promote remyelination could slow the neurological decline associated with chronic demyelination; however, in vivo testing of candidat
Autor:
Luipa Khandker, Marisa A. Jeffries, Yun-Juan Chang, Marie L. Mather, Angelina V. Evangelou, Jennifer N. Bourne, Azadeh K. Tafreshi, Isis M. Ornelas, Ozlem Bozdagi-Gunal, Wendy B. Macklin, Teresa L. Wood
Publikováno v:
Cell reports. 38(9)
Brain and spinal cord oligodendroglia have distinct functional characteristics, and cell-autonomous loss of individual genes can result in different regional phenotypes. However, a molecular basis for these distinctions is unknown. Using single-cell
Autor:
Carolyn N. Brown, Charles L. Edelstein, Daniel J. Atwood, Christopher Altmann, Sarah Faubel, Andrew Thorburn, Nataliya I. Skrypnyk, Sara J. Holditch, Judith Blaine, Jelena Klawitter, Jennifer N. Bourne, Deepak Pokhrel
Publikováno v:
Cell Death and Disease, Vol 12, Iss 3, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
Many surgical models are used to study kidney and other diseases in mice, yet the effects of the surgical procedure itself on the kidney and other tissues have not been elucidated. In the present study, we found that both sham surgery and unilateral