The role of the NMD factor UPF3B in olfactory sensory neurons

Autor: Blue B. Lake, Song Chen, Jennifer N Dumdie, Ling-juan Zhang, Richard L. Gallo, Kun Zhang, Shivam Pandya, Abhishek Sohni, Heidi Cook-Andersen, Eleen Shum, Samantha H Jones, Kun Tan, Miles F. Wilkinson

Publikováno v: eLife
eLife, Vol 9 (2020)

The UPF3B-dependent branch of the nonsense-mediated RNA decay (NMD) pathway is critical for human cognition. Here, we examined the role of UPF3B in the olfactory system. Single-cell RNA-sequencing (scRNA-seq) analysis demonstrated considerable hetero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1fc7cafd3a85484e958b3761fb1799
https://doi.org/10.7554/elife.57525

A Upf3b-mutant mouse model with behavioral and neurogenesis defects

Autor: Amanda J. Roberts, Jozef Gecz, Josh L. Espinoza, Mimi H. Phan, Miles F. Wilkinson, Heidi Cook-Andersen, Jennifer N Dumdie, David Skarbrevik, Samantha H Jones, Neal R. Swerdlow, Chih-Hong Lou, Lulu Huang, Lachlan A. Jolly, Eleen Shum, Kim H

Publikováno v: Molecular psychiatry, vol 23, iss 8

Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA degradation pathway that acts on RNAs terminating their reading frames in specific contexts. NMD is regulated in a tissue-specific and developmentally controlled manner, raisin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56ceebdabc4fe42e203d813e4d9b135
https://doi.org/10.1038/mp.2017.173

Nonsense-Mediated RNA Decay Influences Human Embryonic Stem Cell Fate

Autor: Louise C. Laurent, Eleen Shum, Jennifer N Dumdie, Xiaoyan Liao, Miles F. Wilkinson, David A. Brafman, Alexandra E. Goetz, Heidi Cook-Andersen, Madhuvanthi Ramaiah, Chih-Hong Lou, Sergio Mora-Castilla

Publikováno v: Stem Cell Reports, Vol 6, Iss 6, Pp 844-857 (2016)
Stem Cell Reports
Stem cell reports, vol 6, iss 6

Summary Nonsense-mediated RNA decay (NMD) is a highly conserved pathway that selectively degrades specific subsets of RNA transcripts. Here, we provide evidence that NMD regulates early human developmental cell fate. We found that NMD factors tend to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f392579852b8beb9fdc0499513acb6e
http://www.sciencedirect.com/science/article/pii/S2213671116300637

Chromatin Modification and Global Transcriptional Silencing in the Oocyte Mediated by the mRNA Decay Activator ZFP36L2

Autor: Jennifer N Dumdie, Jens Lykke-Andersen, David Skarbrevik, Sergio Mora-Castilla, Louise C. Laurent, Kyucheol Cho, Deborah J. Stumpo, Perry J. Blackshear, Heidi Cook-Andersen, Miles F. Wilkinson, Madhuvanthi Ramaiah

Publikováno v: Dumdie, Jennifer N; Cho, Kyucheol; Ramaiah, Madhuvanthi; Skarbrevik, David; Mora-Castilla, Sergio; Stumpo, Deborah J; et al.(2018). Chromatin Modification and Global Transcriptional Silencing in the Oocyte Mediated by the mRNA Decay Activator ZFP36L2.. Developmental cell, 44(3), 392-402.e7. doi: 10.1016/j.devcel.2018.01.006. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/9bp7w5p9
Developmental cell, vol 44, iss 3

Global transcriptional silencing is a highly conserved mechanism central to the oocyte-to-embryo transition. We report the unexpected discovery that global transcriptional silencing in oocytes depends on an mRNA decay activator. Oocyte-specific loss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbefb8670a42700b4f95a81e7736d1a
http://www.escholarship.org/uc/item/9bp7w5p9

Miniaturization Technologies for Efficient Single-Cell Library Preparation for Next-Generation Sequencing

Autor: Jennifer N Dumdie, Srimeenakshi Srinivasan, Heidi Cook-Andersen, Robert Morey, Soheila Vaezeslami, Sergio Mora-Castilla, Cuong To, Louise C. Laurent, Joby Jenkins

Publikováno v: Mora-Castilla, Sergio; To, Cuong; Vaezeslami, Soheila; Morey, Robert; Srinivasan, Srimeenakshi; Dumdie, Jennifer N; et al.(2016). Miniaturization Technologies for Efficient Single-Cell Library Preparation for Next-Generation Sequencing.. Journal of laboratory automation, 21(4), 557-567. doi: 10.1177/2211068216630741. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/9n172726
Journal of laboratory automation, vol 21, iss 4
Slas Technology

As the cost of next-generation sequencing has decreased, library preparation costs have become a more significant proportion of the total cost, especially for high-throughput applications such as single-cell RNA profiling. Here, we have applied novel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4415c719cabf9f31a85ac4f4056941fb
http://www.escholarship.org/uc/item/9n172726