Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jennifer N Beck"'
Autor:
Kelly Jin, Kenneth A Wilson, Jennifer N Beck, Christopher S Nelson, George W Brownridge, Benjamin R Harrison, Danijel Djukovic, Daniel Raftery, Rachel B Brem, Shiqing Yu, Mathias Drton, Ali Shojaie, Pankaj Kapahi, Daniel Promislow
Publikováno v:
PLoS Genetics, Vol 18, Iss 4, p e1010199 (2022)
[This corrects the article DOI: 10.1371/journal.pgen.1008835.].
Externí odkaz:
https://doaj.org/article/ad329b2a6af542fbad06457516131dc0
Autor:
Kelly Jin, Kenneth A Wilson, Jennifer N Beck, Christopher S Nelson, George W Brownridge, Benjamin R Harrison, Danijel Djukovic, Daniel Raftery, Rachel B Brem, Shiqing Yu, Mathias Drton, Ali Shojaie, Pankaj Kapahi, Daniel Promislow
Publikováno v:
PLoS Genetics, Vol 16, Iss 7, p e1008835 (2020)
In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found that genotypes within the same species vary widely in how they respond to DR. To explore the mechanisms underlying this variation, we exposed 178 inbr
Externí odkaz:
https://doaj.org/article/6d326a104228454ab46f83d17100e162
Autor:
Sven Lang, Tyler A Hilsabeck, Kenneth A Wilson, Amit Sharma, Neelanjan Bose, Deanna J Brackman, Jennifer N Beck, Ling Chen, Mark A Watson, David W Killilea, Sunita Ho, Arnold Kahn, Kathleen Giacomini, Marshall L Stoller, Thomas Chi, Pankaj Kapahi
Publikováno v:
PLoS Genetics, Vol 15, Iss 8, p e1008318 (2019)
Elevated uric acid (UA) is a key risk factor for many disorders, including metabolic syndrome, gout and kidney stones. Despite frequent occurrence of these disorders, the genetic pathways influencing UA metabolism and the association with disease rem
Externí odkaz:
https://doaj.org/article/8215a5e6533541639565d4c0aab3138d
Autor:
Kenneth A. Wilson, Sudipta Bar, Eric B. Dammer, Enrique M. Carrera, Brian A. Hodge, Tyler A. U. Hilsabeck, Joanna Bons, George W. Brownridge, Jennifer N. Beck, Jacob Rose, Melia Granath-Panelo, Christopher S. Nelson, Grace Qi, Akos A. Gerencser, Jianfeng Lan, Alexandra Afenjar, Geetanjali Chawla, Rachel B. Brem, Philippe M. Campeau, Hugo J. Bellen, Birgit Schilling, Nicholas T. Seyfried, Lisa M. Ellerby, Pankaj Kapahi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR. Knockdown in adulthood inhibited DR-mediat
Externí odkaz:
https://doaj.org/article/3db7a1cee89643b094c27462834817ac
Autor:
Tyler A. U. Hilsabeck, Ru Liu-Bryan, Tracy Guo, Kenneth A. Wilson, Neelanjan Bose, Daniel Raftery, Jennifer N. Beck, Sven Lang, Kelly Jin, Christopher S. Nelson, Tal Oron, Marshall Stoller, Daniel Promislow, Rachel B. Brem, Robert Terkeltaub, Pankaj Kapahi
Publikováno v:
GeroScience, vol 44, iss 4
GeroScience
GeroScience
Elevated serum urate (hyperuricemia) promotes crystalline monosodium urate tissue deposits and gout, with associated inflammation and increased mortality. To identify modifiers of uric acid pathologies, we performed a fly Genome-Wide Association Stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4657fbfcc42b6acd5163051fb15ec7
https://escholarship.org/uc/item/20c3d830
https://escholarship.org/uc/item/20c3d830
Autor:
Rachel B. Brem, Daniel E. L. Promislow, Pankaj Kapahi, Jennifer N. Beck, Tyler A. Hilsabeck, Christopher S. Nelson, Kenneth A. Wilson
Publikováno v:
Curr Biol
Dietary restriction (DR) is the most robust means to extend lifespan and delay age-related diseases across species. An underlying assumption in the aging field is that DR enhances both lifespan and physical activity through similar mechanisms, but th
Autor:
Pankaj Kapahi, Kenneth A. Wilson, Daniel E. L. Promislow, Rachel B. Brem, Tyler A. Hilsabeck, Jennifer N. Beck, Christopher S. Nelson
Publikováno v:
SSRN Electronic Journal.
Dietary restriction (DR) extends lifespan and delays age-related diseases across species. An underlying assumption in the aging field is that DR extends both lifespan and healthspan through similar mechanisms, but this has not been rigorously tested
Autor:
Amit Sharma, Tyler A. Hilsabeck, Kenneth A. Wilson, Deanna J. Brackman, Pankaj Kapahi, Marshall L. Stoller, Jennifer N. Beck, Thomas Chi, Ling Chen, David W. Killilea, Arnold Kahn, Kathleen M. Giacomini, Neelanjan Bose, Sven Lang, Mark A. Watson, Sunita P. Ho
Publikováno v:
PLoS Genetics
PLoS genetics, vol 15, iss 8
PLoS Genetics, Vol 15, Iss 8, p e1008318 (2019)
PLoS genetics, vol 15, iss 8
PLoS Genetics, Vol 15, Iss 8, p e1008318 (2019)
Elevated uric acid (UA) is a key risk factor for many disorders, including metabolic syndrome, gout and kidney stones. Despite frequent occurrence of these disorders, the genetic pathways influencing UA metabolism and the association with disease rem
Predicting Longevity Responses to Dietary Restriction: A Stepping Stone Toward Precision Geroscience
Autor:
Benjamin R Harrison, Ali Shojaie, Shiqing Yu, Christopher S. Nelson, Rachel B. Brem, Kenneth A. Wilson, Pankaj Kapahi, Mathias Drton, Jennifer N. Beck, Danijel Djukovic, George W. Brownridge, Daniel E. L. Promislow, Daniel Raftery, Kelly Jin
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 7, p e1008835 (2020)
PLoS genetics, vol 16, iss 7
PLoS Genetics, Vol 16, Iss 7, p e1008835 (2020)
PLoS genetics, vol 16, iss 7
In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found that genotypes within the same species vary widely in how they respond to DR. To explore the mechanisms underlying this variation, we exposed 178 inbr
Autor:
Amit Sharma, Kenneth A. Wilson, Mark A. Watson, Tyler A. Hilsabeck, Pankaj Kapahi, Sven Lang, Li Chen, Arnold Kahn, Jennifer N. Beck, Marshall L. Stoller, Thomas Chi, Kathy Giacomini, Neelanjan Bose, David W. Killilea, Sunita P. Ho, Deanna J. Brackman
SummaryElevated uric acid (UA) is a key factor for disorders, including gout or kidney stones and result from abrogated expression of Urate Oxidase (Uro) and diet. To understand the genetic pathways influencing UA metabolism we established a Drosophi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29bfb533af5db5f6016eddbc609c207b