Výsledky vyhledávání - "Jennifer N, Shepherd"

Akademický článek

Microbial rhodoquinone biosynthesis proceeds via an atypical RquA-catalyzed amino transfer from S-adenosyl-L-methionine to ubiquinone

Autor: Trilok Neupane, Lydia R. Chambers, Alexander J. Godfrey, Melina M. Monlux, Evan J. Jacobs, Sophia Whitworth, Jamie E. Spawn, Seo Hee K. Clingman, Kathleen L. Vergunst, Fair M. Niven, James J. Townley, Iris W. Orion, Carly R. Goodspeed, Kathryn A. Cooper, Jeff D. Cronk, Jennifer N. Shepherd, David N. Langelaan

Publikováno v: Communications Chemistry, Vol 5, Iss 1, Pp 1-13 (2022)

The RquA protein is required for rhodoquinone biosynthesis; however, its exact function is not yet known. Here, the authors demonstrate that RquA is homologous to SAM-dependent methyltransferases but functions as an aminotransferase using Mn2+ as cof

Externí odkaz: https://doaj.org/article/b2e554daf1fb49c2b8306775749eb555

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Akademický článek

Alternative splicing of coq-2 controls the levels of rhodoquinone in animals

Autor: June H Tan, Margot Lautens, Laura Romanelli-Cedrez, Jianbin Wang, Michael R Schertzberg, Samantha R Reinl, Richard E Davis, Jennifer N Shepherd, Andrew G Fraser, Gustavo Salinas

Publikováno v: eLife, Vol 9 (2020)

Parasitic helminths use two benzoquinones as electron carriers in the electron transport chain. In normoxia, they use ubiquinone (UQ), but in anaerobic conditions inside the host, they require rhodoquinone (RQ) and greatly increase RQ levels. We prev

Externí odkaz: https://doaj.org/article/c592d7ec0d4e4dfcb49e098736479870

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Akademický článek

Investigation of candidate genes involved in the rhodoquinone biosynthetic pathway in Rhodospirillum rubrum.

Autor: Amanda R M Campbell, Benjamin R Titus, Madeline R Kuenzi, Fernando Rodriguez-Perez, Alysha D L Brunsch, Monica M Schroll, Matthew C Owen, Jeff D Cronk, Kirk R Anders, Jennifer N Shepherd

Publikováno v: PLoS ONE, Vol 14, Iss 5, p e0217281 (2019)

The lipophilic electron-transport cofactor rhodoquinone (RQ) facilitates anaerobic metabolism in a variety of bacteria and selected eukaryotic organisms in hypoxic environments. We have shown that an intact rquA gene in Rhodospirillum rubrum is requi

Externí odkaz: https://doaj.org/article/9c4047d86fb743b7bf606157e44e8c82

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Akademický článek

Microbial eukaryotes have adapted to hypoxia by horizontal acquisitions of a gene involved in rhodoquinone biosynthesis

Autor: Courtney W Stairs, Laura Eme, Sergio A Muñoz-Gómez, Alejandro Cohen, Graham Dellaire, Jennifer N Shepherd, James P Fawcett, Andrew J Roger

Publikováno v: eLife, Vol 7 (2018)

Under hypoxic conditions, some organisms use an electron transport chain consisting of only complex I and II (CII) to generate the proton gradient essential for ATP production. In these cases, CII functions as a fumarate reductase that accepts electr

Externí odkaz: https://doaj.org/article/7df347d0d28a4aebb1dcd9bd1626fe87

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