Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Jennifer Munkley"'
Autor:
Chileleko Siachisumo, Sara Luzzi, Saad Aldalaqan, Gerald Hysenaj, Caroline Dalgliesh, Kathleen Cheung, Matthew R Gazzara, Ivaylo D Yonchev, Katherine James, Mahsa Kheirollahi Chadegani, Ingrid E Ehrmann, Graham R Smith, Simon J Cockell, Jennifer Munkley, Stuart A Wilson, Yoseph Barash, David J Elliott
Publikováno v:
eLife, Vol 12 (2024)
Previously, we showed that the germ cell-specific nuclear protein RBMXL2 represses cryptic splicing patterns during meiosis and is required for male fertility (Ehrmann et al., 2019). Here, we show that in somatic cells the similar yet ubiquitously ex
Externí odkaz:
https://doaj.org/article/3a7024d8f2914f8397cd755d8a9c8c64
Autor:
Rebecca Garnham, Daniel Geh, Ryan Nelson, Erik Ramon-Gil, Laura Wilson, Edward N. Schmidt, Laura Walker, Beth Adamson, Adriana Buskin, Anastasia C. Hepburn, Kirsty Hodgson, Hannah Kendall, Fiona M. Frame, Norman Maitland, Kelly Coffey, Douglas W. Strand, Craig N. Robson, David J. Elliott, Rakesh Heer, Matthew Macauley, Jennifer Munkley, Luke Gaughan, Jack Leslie, Emma Scott
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Immune checkpoint blockade has yet to produce robust anti-cancer responses for prostate cancer. Sialyltransferases have been shown across several solid tumours, including breast, melanoma, colorectal and prostate to promote immune suppressio
Externí odkaz:
https://doaj.org/article/d33390bb279b44abab86eb903fea0a8a
Autor:
Kirsty Hodgson, Margarita Orozco-Moreno, Emily Archer Goode, Matthew Fisher, Rebecca Garnham, Richard Beatson, Helen Turner, Karen Livermore, Yuhan Zhou, Laura Wilson, Eline A. Visser, Johan FA. Pijnenborg, Nienke Eerden, Sam J. Moons, Emiel Rossing, Gerald Hysenaj, Rashi Krishna, Ziqian Peng, Kyla Putri Nangkana, Edward N. Schmidt, Adam Duxfield, Ella P. Dennis, Rakesh Heer, Michelle A. Lawson, Matthew Macauley, David J. Elliott, Christian Büll, Emma Scott, Thomas J. Boltje, Richard R. Drake, Ning Wang, Jennifer Munkley
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105163- (2024)
Summary: Background: Bone metastasis is a common consequence of advanced prostate cancer. Bisphosphonates can be used to manage symptoms, but there are currently no curative treatments available. Altered tumour cell glycosylation is a hallmark of can
Externí odkaz:
https://doaj.org/article/afcff439ec0a4487aa2daaa9f610248c
Autor:
Kirsty Hodgson, Margarita Orozco-Moreno, Emma Scott, Rebecca Garnham, Karen Livermore, Huw Thomas, Yuhan Zhou, Jiepei He, Abel Bermudez, Fernando Jose Garcia Marques, Kayla Bastian, Gerald Hysenaj, Emily Archer Goode, Rakesh Heer, Sharon Pitteri, Ning Wang, David J. Elliott, Jennifer Munkley
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Prostate cancer is the most common cancer in men and a major cause of cancer related deaths worldwide. Nearly all affected men develop resistance to current therapies and there is an urgent need to develop new treatments for advanced disease
Externí odkaz:
https://doaj.org/article/0e16f68a0e0b43938c72b47141e9a87b
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Cysteine rich with epidermal growth factor (EGF)-like domains 2 (CRELD2) is an endoplasmic reticulum (ER) resident chaperone protein with calcium binding properties. CRELD2 is an ER-stress regulated gene that has been implicated in the patho
Externí odkaz:
https://doaj.org/article/0b65843fcc6946a69ce958af80de19a6
Autor:
Emma Scott, Rebecca Garnham, Kathleen Cheung, Adam Duxfield, David J. Elliott, Jennifer Munkley
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8184 (2022)
Prostate cancer is the most common cancer in men, and it is primarily driven by androgen steroid hormones. The glycosylation enzyme EDEM3 is controlled by androgen signalling and is important for prostate cancer viability. EDEM3 is a mannosidase that
Externí odkaz:
https://doaj.org/article/dd635f5a050540a8b9bed95eb751904a
Autor:
Jennifer Munkley, Urszula L. McClurg, Karen E. Livermore, Ingrid Ehrmann, Bridget Knight, Paul Mccullagh, John Mcgrath, Malcolm Crundwell, Lorna W. Harries, Hing Y. Leung, Ian G. Mills, Craig N. Robson, Prabhakar Rajan, David J. Elliott
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Cell migration drives cell invasion and metastatic progression in prostate cancer and is a major cause of mortality and morbidity. However the mechanisms driving cell migration in prostate cancer patients are not fully understood. We previou
Externí odkaz:
https://doaj.org/article/49dff917c9574813aafb665056c1069f
Autor:
Jennifer Munkley, Ling Li, S R Gokul Krishnan, Gerald Hysenaj, Emma Scott, Caroline Dalgliesh, Htoo Zarni Oo, Teresa Mendes Maia, Kathleen Cheung, Ingrid Ehrmann, Karen E Livermore, Hanna Zielinska, Oliver Thompson, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Lorna W Harries, Mads Daugaard, Simon Cockell, Nuno L Barbosa-Morais, Sebastian Oltean, David J Elliott
Publikováno v:
eLife, Vol 8 (2019)
Prostate is the most frequent cancer in men. Prostate cancer progression is driven by androgen steroid hormones, and delayed by androgen deprivation therapy (ADT). Androgens control transcription by stimulating androgen receptor (AR) activity, yet al
Externí odkaz:
https://doaj.org/article/4a90da626b1545618d58b1a38a177512
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 455 (2021)
Aberrant glycosylation is a universal feature of cancer cells that can impact all steps in tumour progression from malignant transformation to metastasis and immune evasion. One key change in tumour glycosylation is altered core fucosylation. Core fu
Externí odkaz:
https://doaj.org/article/fd9ee844abdf4c07b5be9e9864e8a3d2
Autor:
Jennifer Munkley, Daniel Vodak, Karen E. Livermore, Katherine James, Brian T. Wilson, Bridget Knight, Paul Mccullagh, John Mcgrath, Malcolm Crundwell, Lorna W. Harries, Hing Y. Leung, Craig N. Robson, Ian G. Mills, Prabhakar Rajan, David J. Elliott
Publikováno v:
EBioMedicine, Vol 8, Iss C, Pp 103-116 (2016)
Steroid androgen hormones play a key role in the progression and treatment of prostate cancer, with androgen deprivation therapy being the first-line treatment used to control cancer growth. Here we apply a novel search strategy to identify androgen-
Externí odkaz:
https://doaj.org/article/bf075f00022b451c9d2a90e31147f783