Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jennifer Mellen"'
Autor:
Xuqing Zhang, Mengyao Luo, Shamael R. Dastagir, Mellissa Nixon, Annie Khamhoung, Andrea Schmidt, Albert Lee, Naren Subbiah, Douglas C. McLaughlin, Christopher L. Moore, Mary Gribble, Nicholas Bayhi, Viral Amin, Ryan Pepi, Sneha Pawar, Timothy J. Lyford, Vikram Soman, Jennifer Mellen, Christopher L. Carpenter, Laurence A. Turka, Thomas J. Wickham, Tiffany F. Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Red blood cells (RBCs) have unique properties that have been exploited for therapeutic uses. Here the authors engineer RBCs to co-express tumor associated antigens on MHC I, 4-1BBL and IL-12, generating artificial antigen presenting cells that can in
Externí odkaz:
https://doaj.org/article/81c7237bdaba401f8b24431f73e5d95a
Autor:
Douglas C. McLaughlin, Naren Subbiah, Timothy J. Lyford, Laurence A. Turka, Xuqing Zhang, Nicholas Bayhi, Shamael R. Dastagir, Mary Gribble, Ryan Pepi, Mengyao Luo, Viral Amin, Tiffany F. Chen, Christopher L. Moore, Annie Khamhoung, Christopher L. Carpenter, Mellissa J. Nixon, Albert Lee, Vikram Soman, Andrea Schmidt, Jennifer Mellen, Sneha Pawar, Thomas Joseph Wickham
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Checkpoint inhibitors and T-cell therapies have highlighted the critical role of T cells in anti-cancer immunity. However, limitations associated with these treatments drive the need for alternative approaches. Here, we engineer red blood cells into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af31c099b49bd4a4f5ad78430492c949
https://doi.org/10.1038/s41467-021-22898-3
https://doi.org/10.1038/s41467-021-22898-3
Autor:
Shannon C. Leonard, Maegan Hoover, Thomas Wickham, Shannon McArdel, Sivan Elloul, Laurence A. Turka, Arjun Bollampalli, Zafira Castaño, Nicholas Bayhi, Christopher L. Carpenter, Enping Hong, Douglas C. McLaughlin, Kelvin Muriuki, Sneha Pawar, Jennifer Mellen, Anne-Sophie Dugast
Publikováno v:
Cancer Immunology, Immunotherapy
Recombinant agonists that activate co-stimulatory and cytokine receptors have shown limited clinical anticancer utility, potentially due to narrow therapeutic windows, the need for coordinated activation of co-stimulatory and cytokine pathways and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fbe885a6cd179d218e17e1b066a9ffe
https://pubmed.ncbi.nlm.nih.gov/34244816
https://pubmed.ncbi.nlm.nih.gov/34244816
Autor:
Douglas C. McLaughlin, Shamael R. Dastagir, Andrea Schmidt, Mellissa J. Nixon, Jennifer Mellen, Tom Wickham, Viral Amin, Albert Lee, Chris Carpenter, Xuqing Zhang, Mengyao Luo, Tiffany F. Chen, Annie Khamhoung, Christopher L. Moore
Publikováno v:
Cancer Research. 80:LB-082
Human papilloma virus (HPV)-infection is strongly associated with the risk of cancer, with the high-risk strain HPV16 accounting for ~80% of head and neck cancers. HPV16+ malignancies remain a critical area of high unmet need for new and innovative t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90430b04baee29da07ff7b0071e697d3
https://doi.org/10.1158/1538-7445.am2020-lb-082
https://doi.org/10.1158/1538-7445.am2020-lb-082
Autor:
Thomas Wickham, Jennifer Mellen, Shannon McArdel, Enping Hong, Maegan Hoover, Sivan Elloul, Torben Straight Nissen, Anne-Sophie Dugast, Douglas C. McLaughlin, Shannon C. Leonard, Christopher L. Carpenter, Arjun Bollampalli
Publikováno v:
Cancer Research. 79:3272-3272
Recombinant agonists that activate co-stimulatory and cytokine receptors have shown limited clinical activity perhaps due to 1) toxicity; 2) a need for coordinated activation of co-stimulatory and cytokine pathways; or 3) the failure of agonist antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1f3863c0ab3c68b0f1acedafbde673d
https://doi.org/10.1158/1538-7445.am2019-3272
https://doi.org/10.1158/1538-7445.am2019-3272
Autor:
Brian Filanoski, Jennifer Mellen, Chris Merritt, Kristi Barker, Roberto D. Polakiewicz, Gokhan Demirkan, Gary K. Geiss, Katherine Crosby, Philippa J. Webster, Douglas Hinerfield
Publikováno v:
Cancer Research. 77:5350-5350
This poster describes a novel fully integrated method for the multiplexed DNA, RNA and Protein analysis of formalin fixed paraffin embedded tumor specimens. Cancer progression is typically a result of aberrations in the molecular pathways that regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49978b3c29fef427dc8ea8deb5985c4a
https://doi.org/10.1158/1538-7445.am2017-5350
https://doi.org/10.1158/1538-7445.am2017-5350