Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jennifer Marlowe"'
Autor:
Harri Lempiäinen, Arne Müller, Sarah Brasa, Soon-Siong Teo, Tim-Christoph Roloff, Laurent Morawiec, Natasa Zamurovic, Axel Vicart, Enrico Funhoff, Philippe Couttet, Dirk Schübeler, Olivier Grenet, Jennifer Marlowe, Jonathan Moggs, Rémi Terranova
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18216 (2011)
Evidence suggests that epigenetic perturbations are involved in the adverse effects associated with some drugs and toxicants, including certain classes of non-genotoxic carcinogens. Such epigenetic changes (altered DNA methylation and covalent histon
Externí odkaz:
https://doaj.org/article/556aff167f6c4c64ad5b0e16f9a0ec15
Publikováno v:
The CASE Journal. 18:390-428
Theoretical basis The case builds upon the theoretical literature in strategy and decision-making under uncertain, complex and ambiguous situations inherent in nascent industries (Eggers and Moeen, 2019). It also bases its analysis of the central dec
Publikováno v:
Current Topics in Nonclinical Drug Development ISBN: 9780429027536
Current Topics in Nonclinical Drug Development
Current Topics in Nonclinical Drug Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46b838d07c44e39a1d4dc3dc73300c7c
https://doi.org/10.1201/9780429027536-5
https://doi.org/10.1201/9780429027536-5
Autor:
Jennifer Y. Tanir, B. Bhaskar Gollapudi, Darrell R. Boverhof, Seiichi Ishida, Jan van Benthem, Masamitsu Honma, James H. Kim, Raymond R. Tice, Scott S. Auerbach, Andrea L. Kasinski, William Slikker, Laura Custer, Véronique Thybaud, Paul D. White, Errol Zeiger, Igor P. Pogribny, Kristine L. Witt, Leon F. Stankowski, Peter C. Dedon, Marilyn J. Aardema, Jennifer Marlowe, Mugimane G. Manjanatha, Stefan Pfuhler
Publikováno v:
Environmental and Molecular Mutagenesis. 56:277-285
Genetic toxicity tests currently used to identify and characterize potential human mutagens and carcinogens rely on measurements of primary DNA damage, gene mutation, and chromosome damage in vitro and in rodents. The International Life Sciences Inst
Autor:
Douglas J. Kornbrust, Jennifer Lockridge, Priya Karmali, Sean Semple, Jennifer Marlowe, Violetta Akopian
Publikováno v:
Nucleic acid therapeutics. 27(4)
The use of lipid formulations has greatly improved the ability to effectively deliver oligonucleotides and has been instrumental in the rapid expansion of therapeutic development programs using oligonucleotide drugs. However, the development of such
Autor:
Min Tseng, Stan Spence, Gregory S. Friedrichs, Elaine Tritto, Leeanne Mclean, Michael Shultz, Jennifer Marlowe, Mark Deurinck, Corinne Emotte, Martin Traebert, Haisong Ju
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 153(1)
Histone deacetylase (HDAC) inhibitors are an emerging class of anticancer agents that modify gene expression by altering the acetylation status of lysine residues of histone proteins, thereby inducing transcription, cell cycle arrest, differentiation
Autor:
David J. Heard, Philippe Marc, Philippe Couttet, Jennifer Marlowe, Harri Lempiäinen, Pierre Moulin, Raphaëlle Luisier, Federico Bolognani, Arne Müller, Jonathan G. Moggs, Olivier Grenet, Rémi Terranova
Publikováno v:
Toxicology and Epigenetics
Autor:
Pedro M. Fernández-Salguero, Manel Esteller, Jennifer Marlowe, Alvaro Puga, Aurea Gomez-Duran, Esteban Ballestar, Jose Maria Carvajal-Gonzalez
Publikováno v:
Journal of Molecular Biology. 380:1-16
Latent TGFbeta-binding protein 1 (LTBP-1) is a key regulator of TGFbeta targeting and activation in the extracellular matrix. LTBP-1 is recognized as a major docking molecule to localize, and possibly to activate, TGFbeta in the extracellular matrix.
Autor:
Mary Beth Genter, Daniel W. Nebert, J. Kevin Kerzee, Nadine Dragin, Jennifer Marlowe, Timothy P. Dalton, Alvaro Puga
Publikováno v:
Biochemical and Biophysical Research Communications. 348:120-123
Naphthalene (NP) has been designated a ‘reasonably anticipated human carcinogen’ because of positive responses in carcinogenicity bioassays in rodents. Whereas CYP2F enzymes are widely regarded as responsible for NP bioactivation, other metabolic
Autor:
Fridolin Treindl, Ute Metzger, Jay I. Goodman, Diethilde Theil, Richard R. Meehan, Elif B. Unterberger, Fanny Giudicelli, M. Marcellin, Dirk Schübeler, Nico Scheer, Rémi Terranova, Clemens Wrzodek, Albert Braeuning, Harri Lempiäinen, Markus F. Templin, Salah Dine Chibout, Michael Schwarz, Magdalena Kalteis, Clifford R. Elcombe, Laurent Morawiec, Veronique Vitry, Jennifer Marlowe, Valerie Dubost, Jonathan G. Moggs, Alberto Del Rio Espinola, Tulipan Zollinger, Pierre Moulin, Roland Wolf, Raphaëlle Luisier, David J. Heard, Ulrich Längle, Philippe Couttet, Florian Hahne, Andreas Zell, Federico Bolognani, Sarah Brasa, Olivier Grenet, Natasa Zamurovic, John P. Thomson, Arne Müller
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 131(2)
The molecular events during nongenotoxic carcinogenesis and their temporal order are poorly understood but thought to include long-lasting perturbations of gene expression. Here, we have investigated the temporal sequence of molecular and pathologica