Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jennifer Malaby"'
Autor:
Puja Sapra, Patricia Kraft, Mary Mehlig, Jennifer Malaby, Hong Zhao, Lee M. Greenberger, Ivan D. Horak
Publikováno v:
Haematologica, Vol 94, Iss 10 (2009)
Examination of the clinical utility of SN38 (10-hydroxy-7-ethyl-camptothecin), the active metabolite of CPT-11, has not been possible to date due to poor solubility of SN38. Here we evaluated the activity of EZN-2208, a water-soluble polyethyleneglyc
Externí odkaz:
https://doaj.org/article/abee49527c7742e2bd1749899e9e955e
Autor:
Nick Loizos, Rolf A. Brekken, Colleen Burns, Timothy Bailey, Jennifer Malaby, Inga Duignan, Michael Peyton, Jason E. Toombs, Michael T. Dellinger, Puja Gupta, David E. Gerber
PDF file, 156K, Species and target specificity of IMC-3G3 and 1E10.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433fb0e5b3f734405f2853cb0aa6d4da
https://doi.org/10.1158/1535-7163.22497432
https://doi.org/10.1158/1535-7163.22497432
Autor:
Nick Loizos, Rolf A. Brekken, Colleen Burns, Timothy Bailey, Jennifer Malaby, Inga Duignan, Michael Peyton, Jason E. Toombs, Michael T. Dellinger, Puja Gupta, David E. Gerber
In lung cancer, platelet-derived growth factor receptor α (PDGFRα) is expressed frequently by tumor-associated stromal cells and by cancer cells in a subset of tumors. We sought to determine the effect of targeting stromal PDGFRα in preclinical lu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874c4025e37e3874f2ebebd8c1b83be5
https://doi.org/10.1158/1535-7163.c.6535614.v1
https://doi.org/10.1158/1535-7163.c.6535614.v1
Autor:
Nick Loizos, Rolf A. Brekken, Colleen Burns, Timothy Bailey, Jennifer Malaby, Inga Duignan, Michael Peyton, Jason E. Toombs, Michael T. Dellinger, Puja Gupta, David E. Gerber
PDF file, 46K.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7225d085b5054d300fe6894dff981838
https://doi.org/10.1158/1535-7163.22497429
https://doi.org/10.1158/1535-7163.22497429
Autor:
Timothy Bailey, Nick Loizos, Jason E. Toombs, David E. Gerber, Jennifer Malaby, Colleen A. Burns, Michael Peyton, Rolf A. Brekken, Inga J Duignan, Michael T. Dellinger, Puja Gupta
Publikováno v:
Molecular Cancer Therapeutics. 11:2473-2482
In lung cancer, platelet-derived growth factor receptor α (PDGFRα) is expressed frequently by tumor-associated stromal cells and by cancer cells in a subset of tumors. We sought to determine the effect of targeting stromal PDGFRα in preclinical lu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a42ffbcb8964f2384bc84c79c499123
https://doi.org/10.1158/1535-7163.mct-12-0431
https://doi.org/10.1158/1535-7163.mct-12-0431
Autor:
Hong Zhao, Mary Mehlig, Puja Sapra, Ivan Horak, Patricia Kraft, Jennifer Malaby, Lee M. Greenberger
Publikováno v:
Haematologica. 94:1456-1459
Examination of the clinical utility of SN38 (10-hydroxy-7-ethyl-camptothecin), the active metabolite of CPT-11, has not been possible to date due to poor solubility of SN38. Here we evaluated the activity of EZN-2208, a water-soluble polyethyleneglyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f1c79c10759ac571196210e99e6e21
https://doi.org/10.3324/haematol.2009.008276
https://doi.org/10.3324/haematol.2009.008276
Autor:
Lee M. Greenberger, Clifford Longley, Puja Sapra, Jennifer Malaby, Hong Zhao, Ivan Horak, Patricia Kraft, Mary Mehlig
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 14(6)
Purpose: Clinical development of SN38, the active metabolite of camptothecin-11 (CPT-11), has been hampered due to its poor solubility. We have developed a novel polymer-drug conjugate, EZN-2208, made by linking SN38 with a multiarm polyethylene glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2115488d00fb12c8ffbc106aa285d0f0
https://pubmed.ncbi.nlm.nih.gov/18347192
https://pubmed.ncbi.nlm.nih.gov/18347192
Autor:
Patricia Kraft, Ivan D. Horak, Clifford Longley, Jennifer Malaby, Hong Zhao, Puja Sapra, Lee M. Greenberger, Mary Mehlig
Publikováno v:
Blood. 110:1397-1397
Background: The clinical utility of SN38 (10-hydroxy-7-ethyl-camptothecin), the active moiety of CPT-11 (Camptosar®), has been severely compromised due to its poor solubility. EZN-2208 is a novel, water-soluble, polyethyleneglycol (PEG)-SN38 conjuga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7dfa860e772f52acce5467f83065200
https://doi.org/10.1182/blood.v110.11.1397.1397
https://doi.org/10.1182/blood.v110.11.1397.1397