Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jennifer MacDiarmid"'
Autor:
Muhammad Babar Khan, Rosamaria Ruggieri, Eesha Jamil, Nhan L. Tran, Camila Gonzalez, Nancy Mugridge, Steven Gao, Jennifer MacDiarmid, Himanshu Brahmbhatt, Jann N. Sarkaria, John Boockvar, Marc Symons
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-17 (2021)
Abstract Background Glioblastoma is the most common primary brain tumor and remains uniformly fatal, highlighting the dire need for developing effective therapeutics. Significant intra- and inter-tumor heterogeneity and inadequate delivery of therape
Externí odkaz:
https://doaj.org/article/c1a6ee476fc8474f99b9f1bb007fbe07
Autor:
Benjamin J Solomon, Jayesh Desai, Mark Rosenthal, Grant A McArthur, Scott T Pattison, Stacey L Pattison, Jennifer MacDiarmid, Himanshu Brahmbhatt, Andrew M Scott
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144559 (2015)
We have harnessed a novel biological system, the bacterial minicell, to deliver cancer therapeutics to cancer cells. Preclinical studies showed that epidermal growth factor receptor (EGFR)-targeted, paclitaxel-loaded minicells (EGFRminicellsPac) have
Externí odkaz:
https://doaj.org/article/d16e1477fb224696921e180eadaf58f8
Publikováno v:
Microbial Biotechnology, Vol 15, Iss 1, Pp 91-94 (2022)
Microbial Biotechnology
Microbial Biotechnology
Autor:
Jann N. Sarkaria, Rosamaria Ruggieri, Himanshu Brahmbhatt, Jennifer Macdiarmid, Muhammad Babar Khan, Marc Symons, John Boockvar, Nhan L. Tran
Publikováno v:
Neuro Oncol
Therapeutic resistance stemming from inter and intra-tumoral heterogeneity is a significant impediment towards development of effective therapeutics for glioblastoma. We hypothesized that microRNAs can potentially counteract resistance emanating from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b543f72a39650c437516b7f738531f
https://europepmc.org/articles/PMC6846215/
https://europepmc.org/articles/PMC6846215/
Autor:
Nancy Mugridge, Jing Ting Zhao, Bruce G. Robinson, Jocelyn Weiss, Himanshu Brahmbhatt, Stan B. Sidhu, Grace T. Y. Kwok, Jennifer Macdiarmid
Publikováno v:
Non-coding RNA Research, Vol 2, Iss 3, Pp 143-150 (2017)
Non-coding RNA Research
Non-coding RNA Research
The search for targeted novel therapies for cancer is ongoing. MicroRNAs (miRNAs) display a number of characteristics making them an attractive and realisable option. In this review, we explore these applications, ranging from diagnostics, prognostic
Autor:
Himanshu Brahmbhatt, Jann N. Sarkaria, Nhan L. Tran, Rosamaria Ruggieri, Marc Symons, Jennifer Macdiarmid, Muhammad Babar Khan, John Boockvar
Publikováno v:
Neuro Oncol
BACKGROUND Glioblastomas show marked intra- and inter-tumor heterogeneity and are strongly resistant to both radio- and chemo-therapy, which are standard therapeutic modalities for this tumor. MicroRNAs (miRNAs) have the potential to serve as effecti
Autor:
John Boockvar, Rosamaria Ruggieri, Jennifer Macdiarmid, Nhan L. Tran, Muhammad Babar Khan, Jann N. Sarkaria, Himanshu Brahmbhatt, Marc Symons
microRNA-34a could serve as a novel therapeutic agent since it is under-expressed in Glioblastoma and modulates the expression of multiple genes in the deregulated p53, Rb and receptor tyrosine kinase networks which confer selective growth advantage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd31a51e23287a48524fe4fc60601ac8
https://europepmc.org/articles/PMC6216883/
https://europepmc.org/articles/PMC6216883/
Publikováno v:
Journal of Clinical Oncology. 38:4632-4632
4632 Background: Targeted EDV nanocells loaded with doxorubicin and microRNA16a have shown excellent safety profiles in Phase I trials in recurrent glioma and mesothelioma. This planned safety analysis of an ongoing first-in-human, open label Phase I
Autor:
Rosamaria Ruggieri, Himanshu Brahmbhatt, Nhan L. Tran, Jennifer Macdiarmid, Marc Symons, Muhammad Khan, John Boockvar, Jann N. Sarkaria
Publikováno v:
Neuro-Oncology. 20:vi74-vi74
microRNA-34a could serve as a novel therapeutic agent as it is under-expressed in Glioblastoma and modulates the expression of multiple genes in the deregulated p53, Rb and receptor tyrosine kinase networks which confer selective growth advantage and
Autor:
Jing Ting Zhao, Matti L Gild, Himanshu Brahmbhatt, Jocelyn Weiss, Lauren Jin Suk Joo, Stan B. Sidhu, Roderick J. Clifton-Bligh, Anthony Gill, Bruce G. Robinson, Jennifer Macdiarmid
Publikováno v:
Cancer Research. 78:501-501
Background Medullary thyroid carcinoma (MTC), which comprises 3-5% of all thyroid cancers, originates from a small population of neuroendocrine calcitonin C-cells of thyroid gland. Gain-of-function mutations of the human Rearranged during Transfectio