Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jennifer M. Spaethling"'
Autor:
Jennifer M. Spaethling, Young-Ji Na, Jaehee Lee, Alexandra V. Ulyanova, Gordon H. Baltuch, Thomas J. Bell, Steven Brem, H. Isaac Chen, Hannah Dueck, Stephen A. Fisher, Marcela P. Garcia, Mugdha Khaladkar, David K. Kung, Timothy H. Lucas Jr., Donald M. O’Rourke, Derek Stefanik, Jinhui Wang, John A. Wolf, Tamas Bartfai, M. Sean Grady, Jai-Yoon Sul, Junhyong Kim, James H. Eberwine
Publikováno v:
Cell Reports, Vol 18, Iss 3, Pp 791-803 (2017)
Investigation of human CNS disease and drug effects has been hampered by the lack of a system that enables single-cell analysis of live adult patient brain cells. We developed a culturing system, based on a papain-aided procedure, for resected adult
Externí odkaz:
https://doaj.org/article/dfca0d124ee0410cac03e2216d6c2535
Autor:
Junhyong Kim, H. Isaac Chen, Mugdha Khaladkar, Alexandra V. Ulyanova, Timothy H. Lucas, Thomas J. Bell, Steven Brem, Hannah Dueck, John A. Wolf, Gordon H. Baltuch, Jaehee Lee, Jinhui Wang, Derek Stefanik, Marcela P. Garcia, David Kung, Stephen A. Fisher, M. Sean Grady, Young Ji Na, Donald M. O'Rourke, Jennifer M. Spaethling, Tamas Bartfai, James Eberwine, Jai-Yoon Sul
Publikováno v:
Cell Reports, Vol 18, Iss 3, Pp 791-803 (2017)
Investigation of human CNS disease and drug effects has been hampered by the lack of a system that enables single-cell analysis of live adult patient brain cells. We developed a culturing system, based on a papain-aided procedure, for resected adult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64007df8f552f30aa67ca245d92bef1f
https://doi.org/10.1016/j.celrep.2016.12.066
https://doi.org/10.1016/j.celrep.2016.12.066
Autor:
Daniel J. Cavanaugh, James Eberwine, Xiangzhong Zheng, Jennifer M. Spaethling, Erik C. Johnson, Amita Sehgal, Clare E. Hector, Julian R. A. Wooltorton, Jill D. Geratowski
Publikováno v:
Cell. 157(3):689-701
SummaryThough much is known about the cellular and molecular components of the circadian clock, output pathways that couple clock cells to overt behaviors have not been identified. We conducted a screen for circadian-relevant neurons in the Drosophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1f4a6a978590eb65b5338674cc100e
Autor:
Jennifer M. Spaethling, James Eberwine
Publikováno v:
Current Opinion in Pharmacology. 13:786-790
Single cell sequencing is currently in its relative infancy although an unprecedented amount of information is already being generated. These techniques are providing new insight into intercellular variability as well as identification of previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8963a49765f92dc3c13de919606ba7
https://doi.org/10.1016/j.coph.2013.04.011
https://doi.org/10.1016/j.coph.2013.04.011
Autor:
Junhyong Kim, James A. Knowles, Jennifer Herstein, Jian-Bing Fan, William J. Mack, James Eberwine, Rui Liu, Jae Mun ‘Hugo’ Kim, Jamie Shallcross, Tae Kyung Kim, Oleg V. Evgrafov, Lina Zheng, Reymundo Dominguez, Christopher P Walker, Tade Souaiaia, Andre Wildberg, Wei Wang, Bo Ding, Rizi Ai, Jennifer M. Spaethling, Adrian Camarena, Ming-Yi Lin, Robert H. Chow, Sean McGroty, Kai Wang, Neeraj Salathia, Stephen A. Fisher, Hannah Dueck, Kun Zhang, Joseph D. Nguyen, Jinhui Wang
Publikováno v:
Dueck, HR; Ai, R; Camarena, A; Ding, B; Dominguez, R; Evgrafov, OV; et al.(2016). Assessing characteristics of RNA amplification methods for single cell RNA sequencing. BMC Genomics, 17(1). doi: 10.1186/s12864-016-3300-3. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/3rv217f7
BMC Genomics
BMC genomics, vol 17, iss 1
BMC Genomics
BMC genomics, vol 17, iss 1
Background Recently, measurement of RNA at single cell resolution has yielded surprising insights. Methods for single-cell RNA sequencing (scRNA-seq) have received considerable attention, but the broad reliability of single cell methods and the facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1dd020a58e63cd43a5786ef5a5b9725
http://www.escholarship.org/uc/item/3rv217f7
http://www.escholarship.org/uc/item/3rv217f7
Autor:
Jennifer M. Spaethling, Wilberg A, Tae Kyung Kim, Ming-Yi Lin, James Eberwine, Adrian Camarena, Robert H. Chow, Wei Wang, Reymundo Dominguez, Sean McGroty, Kun Zhang, James A. Knowles, Jae Mun Kim, Bo Ding, Neeraj Salathia, Oleg V. Evgrafov, Rizi Ai, Tade Souaiaia, Christopher P Walker, Hernstein Js, Mack Wj, Kai Wang, Jian-Bing Fan, Hannah Dueck, Rui Liu, Jae Mun ‘Hugo’ Kim, John D. Nguyen, Stephen A. Fisher, Jamie Shallcross, Lina Zheng, Jingshu Wang
Recently, measurement of RNA at single cell resolution has yielded surprising insights. Methods for single-cell RNA sequencing (scRNA-seq) have received considerable attention, but the broad reliability of single cell methods and the factors governin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4351c7d08130b9504d3d1c760f791f22
https://doi.org/10.1101/045450
https://doi.org/10.1101/045450
Autor:
Peter A. Buckley, Ditte Lovatt, Jennifer M. Spaethling, Terri Schochet, Chantal Francis, James Eberwine, Junhyong Kim, Jacqueline Morris, Tae Kyung Kim, Jai-Yoon Sul, Jaehee Lee, Tiina Peritz, Kevin Miyashiro, Miler T. Lee, Hannah Dueck
Publikováno v:
Journal of the Royal Society Interface
The building blocks of complex biological systems are single cells. Fundamental insights gained from single-cell analysis promise to provide the framework for understanding normal biological systems development as well as the limits on systems/cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949de48c56615db88b37d9da29b6fbce
https://doi.org/10.1098/rsif.2012.0417
https://doi.org/10.1098/rsif.2012.0417
Publikováno v:
Neurobiology of Disease, Vol 46, Iss 3, Pp 646-654 (2012)
Alterations in neuronal cytosolic calcium is a key mediator of the traumatic brain injury (TBI) pathobiology, but less is known of the role and source of calcium in shaping early changes in synaptic receptors and neural circuits after TBI. In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f782ce66d357567a7eb5e73199467a37
http://www.sciencedirect.com/science/article/pii/S0969996112000745
http://www.sciencedirect.com/science/article/pii/S0969996112000745
Autor:
Shachee Doshi, David A. Lynch, Tapan P. Patel, Adam J. Hockenberry, Jennifer M. Spaethling, David F. Meaney, Donna M. Geddes-Klein, Pallab Singh
Publikováno v:
Journal of Biological Chemistry. 287:4348-4359
N-methyl-D-aspartate receptors (NMDARs), critical mediators of both physiologic and pathologic neurological signaling, have previously been shown to be sensitive to mechanical stretch through the loss of its native Mg(2+) block. However, the regulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d3f8751bdc239e9bd52e1eee784c6b
https://doi.org/10.1074/jbc.m111.253740
https://doi.org/10.1074/jbc.m111.253740
Autor:
James Eberwine, Jai-Yoon Sul, Wenshan Wang, Hannah Dueck, Stephen A. Fisher, Junhyong Kim, Feng C. Xia, Jaehee Lee, Patrick Seale, Manuel Sanchez-Alavez, Tamas Bartfai, Jennifer M. Spaethling
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 30(1)
Brown adipocytes (BAs) are specialized for adaptive thermogenesis and, upon sympathetic stimulation, activate mitochondrial uncoupling protein (UCP)-1 and oxidize fatty acids to generate heat. The capacity for brown adipose tissue (BAT) to protect ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b52098ea9606cd89035d8a97ecb95ba
https://pubmed.ncbi.nlm.nih.gov/26304220
https://pubmed.ncbi.nlm.nih.gov/26304220