Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jennifer M. Pfaff"'
Autor:
Scott A. Smith, A. Ruklanthi de Alwis, Nurgun Kose, Eva Harris, Kristie D. Ibarra, Kristen M. Kahle, Jennifer M. Pfaff, Xiaoxiao Xiang, Benjamin J. Doranz, Aravinda M. de Silva, S. Kyle Austin, Soila Sukupolvi-Petty, Michael S. Diamond, James E. Crowe
Publikováno v:
mBio, Vol 4, Iss 6 (2013)
ABSTRACT Following natural dengue virus (DENV) infection, humans produce some antibodies that recognize only the serotype of infection (type specific) and others that cross-react with all four serotypes (cross-reactive). Recent studies with human ant
Externí odkaz:
https://doaj.org/article/4ebe8688b7984900b3d2b984de558908
Potent neutralizing antibodies elicited by dengue vaccine in rhesus macaque target diverse epitopes.
Autor:
Leike Li, Weixu Meng, Melanie Horton, Daniel R DiStefano, Elizabeth A Thoryk, Jennifer M Pfaff, Qihui Wang, Georgina T Salazar, Trevor Barnes, Benjamin J Doranz, Andrew J Bett, Danilo R Casimiro, Kalpit A Vora, Zhiqiang An, Ningyan Zhang
Publikováno v:
PLoS Pathogens, Vol 15, Iss 6, p e1007716 (2019)
There is still no safe and effective vaccine against dengue virus infection. Epidemics of dengue virus infection are increasingly a threat to human health around the world. Antibodies generated in response to dengue infection have been shown to impac
Externí odkaz:
https://doaj.org/article/987313e68b584a3482591ce5d30cb479
Autor:
Jennifer M. Pfaff-Kilgore, Edgar Davidson, Kathryn Kadash-Edmondson, Mayda Hernandez, Erin Rosenberg, Ross Chambers, Matteo Castelli, Nicola Clementi, Nicasio Mancini, Justin R. Bailey, James E. Crowe, Mansun Law, Benjamin J. Doranz
Publikováno v:
Cell Rep
The E1 and E2 envelope proteins of hepatitis C virus (HCV) form a heterodimer that drives virus-host membrane fusion. Here, we analyze the role of each amino acid in E1E2 function, expressing 545 individual alanine mutants of E1E2 in human cells, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568b7169f59effaaca5ddbf21d1abefc
Autor:
Rakshanda Jha, Alexandria J. Shumway, Loryn K. Johnson, Tyler M. Chinsky, Nicole T. Cavanaugh, Susan Tian, Jennifer M. Pfaff, Aditya Gupta, Spencer C. Richman, André O. Hudson, Lauren M. Klafehn, Amanda N. Weiss, Elizabeth D. Tuason, Sara E. Ali, Varada Krishnadas, Ryan J. Musich, Anutthaman Parthasarathy, Chelsea E. Cramer, Narayan H. Wong
Publikováno v:
Journal of Genomics
Are touchscreen devices a public health risk for the transmission of pathogenic bacteria, especially those that are resistant to antibiotics? To investigate this, we embarked on a project aimed at isolating and identifying bacteria that are resistant
Autor:
Georgina To'a Salazar, Elizabeth Thoryk, Danilo R. Casimiro, Qihui Wang, Benjamin J. Doranz, Weixu Meng, Daniel R. DiStefano, Kalpit A. Vora, Andrew J. Bett, Trevor Barnes, Jennifer M. Pfaff, Ningyan Zhang, Leike Li, Zhiqiang An, Melanie Horton
Publikováno v:
PLoS Pathogens, Vol 15, Iss 6, p e1007716 (2019)
PLoS Pathogens
PLoS Pathogens
There is still no safe and effective vaccine against dengue virus infection. Epidemics of dengue virus infection are increasingly a threat to human health around the world. Antibodies generated in response to dengue infection have been shown to impac
Autor:
Christopher Bryan, Manu Mabila, Edgar Davidson, Rachel H. Fong, Trevor Barnes, Jennifer M. Pfaff, Benjamin J. Doranz, Joseph Rucker
Publikováno v:
Journal of Virology
Cocktails of monoclonal antibodies (MAbs) that target the surface glycoprotein (GP) of Ebola virus (EBOV) are effective in nonhuman primate models and have been used under emergency compassionate-treatment protocols in human patients. However, the am
Autor:
Andrew Honda, Leopold Kong, Ian A. Wilson, Radhika Gopal, Jennifer M. Pfaff, Edgar Davidson, Mansun Law, Johnathan D. Guest, Trevor Barnes, Kelli N Jackson, Erick Giang, Netanel Tzarum, Benjamin J. Doranz, Andrew Ettenger
Publikováno v:
PLoS Pathogens
PLOS Pathogens
PLoS Pathogens, Vol 13, Iss 12, p e1006735 (2017)
PLOS Pathogens
PLoS Pathogens, Vol 13, Iss 12, p e1006735 (2017)
The hepatitis C virus (HCV) envelope glycoproteins E1 and E2 form a non-covalently linked heterodimer on the viral surface that mediates viral entry. E1, E2 and the heterodimer complex E1E2 are candidate vaccine antigens, but are technically challeng
Autor:
Valerie J. Cohen, Lisa N. Wasilewski, Shuyi Wang, Stuart C. Ray, Hui Li, Jennifer M. Pfaff, James E. Crowe, Andrea L. Cox, Andrew I. Flyak, Leah B. Loerinc, Rebecca Lampley, Anna E. Snider, George M. Shaw, Justin R. Bailey, Nurgun Kose, Gerald H. Learn, Benjamin J. Doranz
Publikováno v:
JCI Insight. 2
Here, we report the isolation of broadly neutralizing mAbs (bNAbs) from persons with broadly neutralizing serum who spontaneously cleared hepatitis C virus (HCV) infection. We found that bNAbs from two donors bound the same epitope and were encoded b
Autor:
Gopal Sapparapu, Jennifer M. Pfaff, Usha K. Nivarthi, Aravinda M. de Silva, Steve S. Whitehead, James E. Crowe, Ralph S. Baric, Douglas G. Widman, Daniela Weiskopf, Anna P. Durbin, Benjamin J. Doranz, Nurgun Kose, Emily N. Gallichotte, Alessandro Sette
The four dengue virus (DENV) serotypes are mosquito-borne flaviviruses responsible for dengue fever and dengue hemorrhagic fever. People exposed to DENV develop antibodies (Abs) that strongly neutralize the serotype responsible for infection. Histori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40aefbdcd01a6586bde400142db63bdc
Autor:
Matteo Castelli, Nicasio Mancini, Jennifer M. Pfaff, Matteo Dal Peraro, Nicola Clementi, Roberta Antonia Diotti, Benjamin J. Doranz, Roberto Burioni, Giuseppe A. Sautto, Massimo Clementi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
The design of vaccine strategies and the development of drugs targeting the early stages of Hepatitis C virus (HCV) infection are hampered by the lack of structural information about its surface glycoproteins E1 and E2, the two constituents of HCV en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2a1f310aa2cea6d0bda25b9aec4dfb