The m6A methyltransferase METTL3 regulates muscle maintenance and growth in mice

Autor: Jennifer M. Petrosino, Scott A. Hinger, Volha A. Golubeva, Juan M. Barajas, Lisa E. Dorn, Chitra C. Iyer, Hui-Lung Sun, W. David Arnold, Chuan He, Federica Accornero

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

Muscle undergoes hypertrophy and atrophy in response to physiological stimuli or in pathological conditions, which is partially controlled through altered gene expression. Here the authors report that m6A methyltransferase METTL3 and mRNA m6A post-tr

Externí odkaz: https://doaj.org/article/1a052b16c28446cb99698ffe0e5759b1

NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model

Autor: Jennifer M. Peterson, David J. Wang, Vikram Shettigar, Steve R. Roof, Benjamin D. Canan, Nadine Bakkar, Jonathan Shintaku, Jin-Mo Gu, Sean C. Little, Nivedita M. Ratnam, Priya Londhe, Leina Lu, Christopher E. Gaw, Jennifer M. Petrosino, Sandya Liyanarachchi, Huating Wang, Paul M. L. Janssen, Jonathan P. Davis, Mark T. Ziolo, Sudarshana M. Sharma, Denis C. Guttridge

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

The molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function throug

Externí odkaz: https://doaj.org/article/aa724b3e4c7b4ada9b67a708841b1195

Mineralocorticoid Receptor Signaling Contributes to Normal Muscle Repair After Acute Injury

Autor: J. Spencer Hauck, Zachary M. Howard, Jeovanna Lowe, Neha Rastogi, Madison G. Pico, Sarah A. Swager, Jennifer M. Petrosino, Celso E. Gomez-Sanchez, Elise P. Gomez-Sanchez, Federica Accornero, Jill A. Rafael-Fortney

Publikováno v: Frontiers in Physiology, Vol 10 (2019)

Acute skeletal muscle injury is followed by a temporal response of immune cells, fibroblasts, and muscle progenitor cells within the muscle microenvironment to restore function. These same cell types are repeatedly activated in muscular dystrophy fro

Externí odkaz: https://doaj.org/article/12798ee57d8e4204a1997bf5cc71cfd1

Microfibrillar-Associated Protein 4 Regulates Stress-Induced Cardiac Remodeling

Autor: Matthew S. Stratton, Federica Accornero, Bryan A. Whitson, Xianyao Xu, Peter J. Mohler, Anders Schlosser, Grith Lykke Sørensen, William R Lawrence, Jennifer M. Petrosino, Paul M.L. Janssen, Thomas J. Hund, Lisa E. Dorn

Publikováno v: Circ Res
Dorn, L E, Lawrence, W, Petrosino, J M, Xu, X, Hund, T J, Whitson, B A, Stratton, M S, Janssen, P M L, Mohler, P J, Schlosser, A, Sorensen, G L & Accornero, F 2021, ' Microfibrillar-Associated Protein 4 Regulates Stress-Induced Cardiac Remodeling ', Circulation Research, vol. 128, no. 6, pp. 723-737 . https://doi.org/10.1161/CIRCRESAHA.120.317146

Rationale: Cardiac hypertrophy, a major risk factor for heart failure, occurs when cardiomyocytes remodel in response to complex signaling induced by injury or cell stress. Although cardiomyocytes are the ultimate effectors of cardiac hypertrophy, no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb8f6e1525707a6c3efaa1b731e801b
https://doi.org/10.1161/circresaha.120.317146

The m

Autor: Jennifer M, Petrosino, Scott A, Hinger, Volha A, Golubeva, Juan M, Barajas, Lisa E, Dorn, Chitra C, Iyer, Hui-Lung, Sun, W David, Arnold, Chuan, He, Federica, Accornero

Publikováno v: Nature Communications

Skeletal muscle serves fundamental roles in organismal health. Gene expression fluctuations are critical for muscle homeostasis and the response to environmental insults. Yet, little is known about post-transcriptional mechanisms regulating such fluc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::362a7a5bdd53f92cfc7dc95803b80eb9
https://pubmed.ncbi.nlm.nih.gov/35013323